Observations on the Preparation, Properties and Source of the Parathyroid Hormone. Part I

Davies, Daniel T.; Dickens, F.; Dodds, E. C.

doi:10.1042/bj0200695

Cited by 27 publications

(5 citation statements)

References 2 publications

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“…Thirdly, rabbits are not very suitable animals for this purpose, as it requires large doses to influence their calcium blood-level. DAVIES, DICKENS, and DODDS (26) found that the rabbit is much more resistant to the action of the parathyroid hormone than is the dog. It is interesting, incidentally, that the minimum amount of parathyroid which these authors found sufficient to produce a rise of blood calcium in rabbits was 15 grm.…”

Section: Results Effect Of Liquor Folliculimentioning

confidence: 99%

The Influence of the Internal Secretions of the Ovary on the Calcium Blood Level and on Calcium Metabolism

Mirvish

Bosman

1927

Exp Physiol

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1. An ovarian extract has been prepared, which, when administered to animals, produces a fall in blood calcium. 2. The active principle has been found to be present in extracts of liquor folliculi, residual ovary, and corpus luteum. It is also present in placenta. 3. The fall in blood calcium amounts in typical cases to 30–35 percent. of the normal value. The blood calcium cannot generally be reduced any lower than this by increasing or repeating the dose. 4. The maximum fall in blood calcium is usually produced in about twenty‐four hours, and it returns to normal in forty‐eight hours. 5. The action of the hormone on the blood calcium is the same in both sexes. 6. The extract is active when administered subcutaneously or intraperitoneally. It is also active on oral administration when the dose is considerably increased. 7. Injection of the extract as an emulsion in distilled water is inactive. It is active when dissolved in olive‐oil or weak sodium bicarbonate solution. 8. The result of ovariotomy in rabbits is the production of wide fluctuations in the blood calcium level. 9. The action of the ovarian hormone on the blood calcium is suggested as a means for standardisation. 10. It is suggested that the mode of action of the ovarian hormone is by influencing other endocrine glands. We desire to express our thanks to the Research Grant Board of this University for meeting portion of the expense involved in these researches; and also to Professors W. A. Jolly and E. S. Edie for their interest in the work.

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Section: Results Effect Of Liquor Folliculimentioning

confidence: 99%

The Influence of the Internal Secretions of the Ovary on the Calcium Blood Level and on Calcium Metabolism

Mirvish

Bosman

1927

Exp Physiol

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“…following injection of insulin (31). Davies, Dickens, and Dodds (32) found increases of from 2 to 4 mgm. in serum calcium of rabbits in hypoglycemic convulsions.…”

Section: Absolute Rest and Mild Exercisementioning

confidence: 99%

Studies of Calcium and Phosphorus Metabolism

Farquharson¹,

Tibbetts²

1931

J. Clin. Invest.

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In the investigation of various problems of calcium and phosphorus metabolism, it has been found that great changes in the volume and direction of the calcium and phosphorus stream may occur without any notable difference in the serum levels of these elements. In hyperthyroidism the calcium excretion in the urine is relatively huge and there are large negative balances of calcium and phosphorus, yet the serum calcium and serum phosphorus' remain within normal limits (1). Moreover, there is no appreciable change in the serum levels of healthy people when, by changing the calcium intake, a positive balance is shifted to a negative one or vice versa.Yet the actual and relative amounts of calcium and phosphorus in the serum is of the utmost importance in certain abnormal conditions. MacCallum and Voegtlin (2) described the low blood and tissue calcium associated with tetany after removal of the parathyroids.Greenwald (3) later demonstrated the associated rise in serum phosphorus and since that time the high phosphorus, low calcium of the serum in many types of tetany has come to be recognized. Marriot and Howland (4), DeWesselow (5) and others have found a similar relationship of the serum values in terminal nephritis. On injection of large amounts of inorganic phosphate into dogs Binger (6) produced tetany with a low serum calcium and high serum phosphorus. Similar results have been found to follow injection or ingestion of very large quantities of phosphate by numerous investigators (7,8,9). The 1 Throughout this paper the term "serum phosphorus" is used in referring to serum inorganic phosphorus.

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“…It has generally been concluded from the absence of effects or from the relatively slight effects upon serum calcium after parathormone injection in rabbits and guinea pigs that these animals are tolerant to parathormone (1)(2)(3)(4)(5)(6). We have observed that young guinea pigs respond to the dally injection of relatively large doses of parathormone by decalcification and secondary fibrous transformation of the more rapidly growing bones or portions of bones (7).…”

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The Effects of Parathormone and Ammonium Chloride on the Bones of Rabbits

Jaffe

Bodansky

Blair

1932

Journal of Experimental Medicine

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It has generally been concluded from the absence of effects or from the relatively slight effects upon serum calcium after parathormone injection in rabbits and guinea pigs that these animals are tolerant to parathormone (1-6). We have observed that young guinea pigs respond to the dally injection of relatively large doses of parathormone by decalcification and secondary fibrous transformation of the more rapidly growing bones or portions of bones (7). These effects occur in spite of the fact that the guinea pig is relatively resistant to parathormone, as measured by hypercalcemia, although with sufficiently large doses of parathormone both hypercalcemia and hyperphosphatemia may be induced (8). In young and adult guinea pigs a compensation is established during prolonged parathormone treatment, which enables them to tolerate repeated large doses without hypercalcemia, and which permits considerable repair of the bone lesions produced earlier in the treatment (8, 9).We therefore studied histologically the bones of a rabbit treated with a single large dose of parathonnone, and of a number of rabbits treated for long periods with parathormone alone, and with parathormone supplemented with calcium lactate or ammonium chloride. Effect of a Single Large Dose of ParathormoneWe found in a single test, 48 hours after an injection of 240 units of parathormone into a young rabbit (No. 301) weighing about 500 gm., definite hypercalcemia as well as hyperphosphatemia (serum calcium 17.2, serum phosphorus 9.3 rag. per 100 cc.). There was other evidence of extreme overdosage in a non-protein nitrogen value of 103 rag. per 100 cc. The animal was apparently moribund when 595

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Observations on the Preparation, Properties and Source of the Parathyroid Hormone. Part I

Abstract: THE isolation of a parathyroid hormone has been described by Collip and his co-workers [(ollip, 1925, 1

Cited by 27 publications

References 2 publications

The Influence of the Internal Secretions of the Ovary on the Calcium Blood Level and on Calcium Metabolism

The Influence of the Internal Secretions of the Ovary on the Calcium Blood Level and on Calcium Metabolism

Studies of Calcium and Phosphorus Metabolism

The Effects of Parathormone and Ammonium Chloride on the Bones of Rabbits

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