Observations on the pharmacology and hemolytic activity of dimethyl sulfoxide

DiStefano, Victor; Klahn, Janet J.

doi:10.1016/0041-008x(65)90122-5

Cited by 42 publications

(20 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While addition (49), who had two of three unanesthetized cats survive an intravenous dose of 3 g/kg DMSO and one of three survive 6 g/kg to approximate an LD50 of 4 g/kg. This is in con trast to the maximum single intravenous dose of 0.4 g/kg of DMSO for anesthetized cats found by DiStefano et al (93). Braude & Monroe's (80-82) studies, already mentioned, showed that 5 g/kg of DMSO ad m inistered intraperitoneally to mice decreased spontaneous motor activity (SMA) and increased hexobarbital sleeping time (RST).…”

Section: Pharmacologymentioning

confidence: 71%

See 1 more Smart Citation

The Pharmacology of Dimethyl Sulfoxide

David¹

1972

Annu. Rev. Pharmacol.

169

View full text Add to dashboard Cite

Section: Pharmacologymentioning

confidence: 71%

“…Other workers (93) found that initial intravenous dosages of 200 mg/kg of undiluted DMSO produced apnea in the cat but subsequent dosages of the same mag nitude did not. Blood pressure and heart rate fell transiently after intrave nous administration of 200 mg/kg of DMSO.…”

Section: Pharmacologymentioning

confidence: 96%

The Pharmacology of Dimethyl Sulfoxide

David¹

1972

Annu. Rev. Pharmacol.

169

View full text Add to dashboard Cite

“…DMSO has also been shown to affect collagen biosynthesis [14] to have an antipyretic activity [35], to have some effect on blood pressure [36] and respiration [37] in cats and dogs, to increase diuresis [38], to possess histamine-like vasodilatatory properties [39], to depress smooth muscle function [40], to have central nervous antipsychotic effects [41] and to have bacteriostatic properties [42]. It would be of more than theoretical interest to find out what spectrum of biological properties is observed with other sulfoxides and to establish if they might have a higher therapeutic index than DMSO.…”

Section: Discussionmentioning

confidence: 99%

About some biochemical properties of dimethylsulfoxide and three of its homologues: Is the acidic function essential for nonsteroidal antiinflammatory activities?

Famaey

Whitehouse

1974

Agents and Actions

View full text Add to dashboard Cite

Dimethylsulfoxide and three related sulfoxides exhibit some of the biochemical properties of classical non steroidal antiinflammatory acidic drugs. Thus n-propyl sulfoxide, n-butyl sulfoxide and tetramethylene sulfoxide stimulate 02 consumption by rat liver mitochondria. These 3 compounds induce mitochondrial swelling. Lymphocyte swelling is only induced by high doses of n-propyl sulfoxide and n-butyl sulfoxide and not by tetramethylene sulfoxide.These suffoxides induce changes in membrane permeability of various lymphocytes to ions by increasing 45Ca, 86Rb, 134Cs and 22Na fluxes across these membranes, the direction and the magnitude of which are dependent on the ionic composition of the medium and sulfoxide concentration.They all inhibit the incorporation of 3H-thymidine, aH-uridine and 14C-aminoacids into lymphocytes DNA, RNA and proteins.The relevance of such biochemical properties for analgesic or antiinflammatory clinical effects is discussed.

show abstract

“…The optimal concentration of DMSO to reconstitute PF-04886847 was empirically determined. The toxicity of DMSO is well established in the literature for decades[29, 30]. Thus, very few rats were used for the DMSO studies so that pointless test and suffering could be reduced.…”

Section: Methodsmentioning

confidence: 99%

PF-04886847 (an Inhibitor of Plasma Kallikrein) Attenuates Inflammatory Mediators and Activation of Blood Coagulation in Rat Model of Lipopolysaccharide (LPS) - Induced Sepsis

Kolte

Bryant²,

Gibson³

et al. 2012

CHAMC

View full text Add to dashboard Cite

The plasma kallikrein-mediated proteolysis regulates both thrombosis and inflammation. Previous study has shown that PF-04886847 is a potent and competitive inhibitor of kallikrein, suggesting that it might be useful for the treatment of kallikrein-kinin mediated inflammatory and thrombotic disorders. In the rat model of lipopolysaccharide (LPS) -induced sepsis used in this study, pretreatment of rats with PF-04886847 (1 mg/kg) prior to LPS (10 mg/kg) prevented endotoxin-induced increase in granulocyte count in the systemic circulation. PF-04886847 significantly reduced the elevated plasma 6-keto PGF1α levels in LPS treated rats, suggesting that PF-04886847 could be useful in preventing hypotensive shock during sepsis. PF-04886847 did not inhibit LPS-induced increase in plasma TNF-α level. Pretreatment of rats with PF-04886847 prior to LPS did not attenuate endotoxin-induced decrease in platelet count and plasma fibrinogen levels as well as increase in plasma D-dimer levels. PF-04886847 did not protect the animals against LPS-mediated acute hepatic and renal injury and disseminated intravascular coagulation (DIC). Since prekallikrein (the zymogen form of plasma kallikrein) deficient patients have prolonged aPPT without having any bleeding disorder, the anti-thrombotic property and mechanism of action of PF-04886847 was assessed. In a rabbit balloon injury model designed to mimic clinical conditions of acute thrombotic events, PF-04886847 reduced thrombus mass dose-dependently. PF-04886847 (1 mg/kg) prolonged both activated partial thromboplastin time (aPTT) and prothrombin time (PT) in a dose-dependent manner. Although the findings of this study indicate that PF-04886847 possesses limited anti-thrombotic and anti-inflammatory effects, PF-04886847 may have therapeutic potential in other kallikrein-kinin mediated diseases.

show abstract

Observations on the pharmacology and hemolytic activity of dimethyl sulfoxide

Cited by 42 publications

References 5 publications

The Pharmacology of Dimethyl Sulfoxide

The Pharmacology of Dimethyl Sulfoxide

About some biochemical properties of dimethylsulfoxide and three of its homologues: Is the acidic function essential for nonsteroidal antiinflammatory activities?

PF-04886847 (an Inhibitor of Plasma Kallikrein) Attenuates Inflammatory Mediators and Activation of Blood Coagulation in Rat Model of Lipopolysaccharide (LPS) - Induced Sepsis

Contact Info

Product

Resources

About