Observations on the occurrence of<i>Heterakis gallinarum</i>in laying hens kept on soil

Papini, Roberto Amerigo; Cacciuttolo, E

doi:10.4081/ijas.2008.487

Cited by 7 publications

(4 citation statements)

References 10 publications

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“…, 2011; Höglund & Jansson, 2011; Jansson et al. , 2010; Papini & Cacciuttolo, 2008). Strategies to deworming are being introduced in the avian production systems with the limitation that FLBZ is currently the only anthelmintic licensed to be used in poultry.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, an increasing prevalence of roundworms, especially in litter-based housing systems, associated with increased exposure to parasites with a fecal-oral route of transmission has been reported (Stafford et al, 2011;Höglund & Jansson, 2011;Jansson et al, 2010;Papini & Cacciuttolo, 2008). Strategies to deworming are being introduced in the avian production systems with the limitation that FLBZ is currently the only anthelmintic licensed to be used in poultry.…”

Section: Discussionmentioning

confidence: 99%

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Disposition kinetics of albendazole and metabolites in laying hens

Bistoletti

Álvarez

Lanusse

et al. 2012

Vet Pharm & Therapeutics

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An increasing prevalence of roundworm parasites in poultry, particularly in litter-based housing systems, has been reported. However, few anthelmintic drugs are commercially available for use in avian production systems. The anthelmintic efficacy of albendazole (ABZ) in poultry has been demonstrated well. The goal of this work was to characterize the ABZ and metabolites plasma disposition kinetics after treatment with different administration routes in laying hens. Twenty-four laying hens Plymouth Rock Barrada were distributed into three groups and treated with ABZ as follows: intravenously at 10 mg/kg (ABZ i.v.); orally at the same dose (ABZ oral); and in medicated feed at 10 mg/kg·day for 7 days (ABZ feed). Blood samples were taken up to 48 h posttreatment (ABZ i.v. and ABZ oral) and up to 10 days poststart feed medication (ABZ feed). The collected plasma samples were analyzed using high-performance liquid chromatography. ABZ and its albendazole sulphoxide (ABZSO) and ABZSO2 metabolites were recovered in plasma after ABZ i.v. administration. ABZ parent compound showed an initial concentration of 16.4 ± 2.0 μg/mL, being rapidly metabolized into the ABZSO and ABZSO2 metabolites. The ABZSO maximum concentration (Cmax ) (3.10 ± 0.78 μg/mL) was higher than that of ABZSO2 Cmax (0.34 ± 0.05 μg/mL). The area under the concentration vs time curve (AUC) for ABZSO (21.9 ± 3.6 μg·h/mL) was higher than that observed for ABZSO2 and ABZ (7.80 ± 1.02 and 12.0 ± 1.6 μg·h/mL, respectively). The ABZ body clearance (Cl) was 0.88 ± 0.11 L·h/kg with an elimination half-life (T1/2el ) of 3.47 ± 0.73 h. The T1/2el for ABZSO and ABZSO2 were 6.36 ± 1.50 and 5.40 ± 1.90 h, respectively. After ABZ oral administration, low ABZ plasma concentrations were measured between 0.5 and 3 h posttreatment. ABZ was rapidly metabolized to ABZSO (Cmax , 1.71 ± 0.62 μg/mL) and ABZSO2 (Cmax , 0.43 ± 0.04 μg/mL). The metabolite systemic exposure (AUC) values were 18.6 ± 2.0 and 10.6 ± 0.9 μg·h/mL for ABZSO and ABZSO2 , respectively. The half-life values after ABZ oral were similar (5.91 ± 0.60 and 5.57 ± 1.19 h for ABZSO and ABZSO2 , respectively) to those obtained after ABZ i.v. administration. ABZ was not recovered from the bloodstream after ABZ feed administration. AUC values of ABZSO and ABZSO2 were 61.9 and 92.4 μg·h/mL, respectively. The work reported here provides useful information on the pharmacokinetic behavior of ABZ after both i.v. and oral administrations in hens, which is a useful first step to evaluate its potential as an anthelmintic tool for use in poultry.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Disposition kinetics of albendazole and metabolites in laying hens

Bistoletti

Álvarez

Lanusse

et al. 2012

Vet Pharm & Therapeutics

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“…Aviary and deep-litter systems with or without access to a free-range area are increasingly used in European egg production units. This production system has the advantage to promote natural behaviour and increase animal welfare with the inconvenient that a increased exposure to helminth parasites with a fecal-oral route of transmission has been reported (Papini and Cacciuttolo, 2008;Jansson et al 2010;Höglund and Jansson, 2011;Kaufmann et al 2011) Among the poultry helminths, Ascaridia galli and Heterakis gallinarum are the most common species (Permin et al 1999). They can cause weight depression (Kilpinen et al 2005) and damage the intestinal mucosa, sometimes leading to haemorrhages, anaemia and severe diarrhoea.…”

Section: Introductionmentioning

confidence: 99%

Effects of feeding on the plasma disposition kinetics of the anthelmintic albendazole in laying hens

Bistoletti

Álvarez

Lanusse

et al. 2014

British Poultry Science

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1. To optimise the use of albendazole (ABZ) as an anthelmintic in hens, the effects of fasting and type of diet on the plasma kinetics of ABZ and its metabolites were evaluated. 2. Twenty-four hens were distributed into 4 groups: In experiment I the Fed group were fed ad libitum, while the Fasted group was fasted over a 12-h period. In experiment II the Pelleted group was fed with pelleted commercial food, while the Grain group was fed with cereal grains. All the groups were treated with ABZ by oral route. Blood samples were taken and plasma analysed by HPLC. 3. ABZ and its metabolites albendazole-sulphoxide (ABZSO) and albendazole-sulphone (ABZSO2) were recovered in plasma in all the groups. The 12-h fasting period did not modify the disposition kinetics of ABZ in hens. The type of feed affected ABZ kinetics. ABZSO concentration profile was higher and detected for longer in the Grain group compared to the Pelleted group. Statistical differences were not found for AUC0-∞ values, whereas the T1/2for and T1/2el were different between groups. 4. Factors affecting ABZ kinetic behaviour should be taken into account to optimise its use to ensure the sustainability of the limited available anthelmintic therapeutic tools in avian parasite control.

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“…6 This nematode also plays a role in histomoniasis (black head disease) epidemiology in turkeys where it causes severe disease and high mortality, sometimes up to 100% of a flock. 7,8 Ascaridia galli causes ascaridiosis with reduced feed conversion and mortality in birds.…”

Section: Introductionmentioning

confidence: 99%