Observations on the Mechanism of the Renal Clearance of I1311

Bricker, Neal S.; Hlad, C. J.

doi:10.1172/jci103155

Cited by 58 publications

(19 citation statements)

References 13 publications

(15 reference statements)

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“…per minute both on and off salicylate therapy. This value is slightly higher than that usually observed (39)(40)(41). Bricker and Hlad (41) have demonstrated that a water diuresis up to 6 ml.…”

Section: Radiothyroxinementioning

confidence: 52%

See 1 more Smart Citation

Salicylates and Thyroid Function. I. Depression of Thyroid Function

Austen¹,

Rubini²,

Meroney³

et al. 1958

J. Clin. Invest.

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Section: Radiothyroxinementioning

confidence: 52%

“…This value is slightly higher than that usually observed (39)(40)(41). Bricker and Hlad (41) have demonstrated that a water diuresis up to 6 ml. per minute does not alter renal clearance of radioiodine, but they did not carry the diuresis to the rates of urine flow used in the present study.…”

Section: Radiothyroxinementioning

confidence: 52%

Salicylates and Thyroid Function. I. Depression of Thyroid Function

Austen¹,

Rubini²,

Meroney³

et al. 1958

J. Clin. Invest.

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“…To intensify and hasten the depletion of iodide, advantage was taken of earlier observations indicating that the renal clearance of iodide is enhanced during osmotic diuresis (18). Patients were given a priming dose of 250 to 500 ml of 20% solution of mannitol followed by a sustaining infusion of 400 g of mannitol delivered in a 10% solution over a period of 6 hours.…”

Section: Methodsmentioning

confidence: 99%

The Effect of Acute Iodide Depletion on Thyroid Function in Man*

Barakat¹,

Ingbar²

1965

J. Clin. Invest.

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“…In ten studies (six on R and four on D) glomerular filtration rate (GFR) was measured by the clearance of inulin (C,3) using standard renal clearance techniques as previously described (2). In nine of these ten studies, effective renal plasma flow (ERPF) was measured by the clearance of p-aminohippurate (ClAN).…”

Section: Methodsmentioning

confidence: 99%

Studies on the Functional Capacity of a Denervated Homotransplanted Kidney in an Identical Twin With Parallel Observations in the Donor 1

Bricker¹,

Guild²,

Reardan³

et al. 1956

J. Clin. Invest.

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The successful transplantation of a human kidney between 24-year-old male identical twins has made possible the study of the function of a homotransplanted kidney. The purposes of the study were twofold: 1) to evaluate the functional capacity of the transplanted kidney; 2) more specifically, to investigate the capacity of a transplanted, and therefore totally denervated, kidney to regulate renal hemodynamics and electrolyte and water excretion.Studies were performed on both the recipient (R) and the donor (D). All but one of the experiments on R were performed after his own two kidneys had been surgically removed; thus, the majority of the data obtained specifically de- Association.preliminary study, during which time the twins were shown to be identical, D's left kidney was transplanted retroperitoneally into the right iliac fossa of R. End to end anastomoses were effected between the renal artery of the transplanted organ and the recipient's right hypogastric artery and between the renal vein and the right common iliac vein. The ureter was implanted directly into the urinary bladder. Clinical improvement began in the immediate postoperative period and continued until all the apparent stigmata of both uremia and hypertension regressed. Bilateral nephrectomy was performed in a two-stage procedure at three and at five and one-half months following transplantation, leaving R with only the transplanted organ. To date he has enjoyed over a year of total well being on an unrestricted regimen. Detailed accounts of the clinical course and operative procedure have been previously described (1). ProcedureTwenty-three clearance studies and several miscellaneous experiments were performed over an eighteen-month period. Control studies were obtained on D prior to transplantation. The majority of observations on R was made during a four-month interval beginning six months after transplantation.Except where indicated, all studies were performed in the morning with the subjects postprandial and recumbent. In ten studies (six on R and four on D) glomerular filtration rate (GFR) was measured by the clearance of inulin (C,3) using standard renal clearance techniques as previously described (2). In nine of these ten studies, effective renal plasma flow (ERPF) was measured by the clearance of p-aminohippurate (ClAN). In six of the studies in which C,3 was measured, urine was collected through an inlying soft rubber multiholed catheter, and urine collection periods (15 to 20 minutes in duration) were concluded with two washouts of distilled water and two or more injections of air. In the control and early postoperative studies on D and the postoperative (left nephrectomy) and osmotic diuresis studies on R, bladder catheterization was not performed.In an additional ten studies (six on R and four on D) endogenous creatinine clearance (Cc,) was employed to estimate trends in GFR. These studies were carried out using voided specimens. In the majority of individual 1364

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Observations on the Mechanism of the Renal Clearance of I1311

Cited by 58 publications

References 13 publications

Salicylates and Thyroid Function. I. Depression of Thyroid Function

Salicylates and Thyroid Function. I. Depression of Thyroid Function

The Effect of Acute Iodide Depletion on Thyroid Function in Man*

Studies on the Functional Capacity of a Denervated Homotransplanted Kidney in an Identical Twin With Parallel Observations in the Donor 1

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