Observations on the histologic features of the human edentulous ridge. Part III: Bone

Krajicek, Dayton Dunbar; Dooner, John; Porter, Kendall

doi:10.1016/s0022-3913(84)80015-3

Cited by 10 publications

(2 citation statements)

References 14 publications

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“…3 and see [ 54 ]), and in both the periosteum overlying the edentulous site is osteogenic, with defects evident in the cortical bone structure ( Fig. 1A , B and see [ 55 ]). In addition, both exhibit a pattern of lamellar bone with minimal marrow spaces ( Fig.…”

Section: Discussionmentioning

confidence: 99%

Bioactivating a bone substitute accelerates graft incorporation in a murine model of vertical ridge augmentation

Chen

Yuan

et al. 2020

Dental Materials

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Objective. Compared to autologous bone grafts, allogeneic bone grafts integrate slowly, which can adversely affect clinical outcomes. Here, our goal was to understand the molecular mechanisms underlying graft incorporation, and then test clinically feasible methods to accelerate this process. Methods. Wild-type and transgenic Wnt “reporter” mice were used in a vertical ridge augmentation procedure. The surgery consisted of tunneling procedure to elevate the maxillary edentulous ridge periosteum, followed by the insertion of bone graft. Micro-computed tomographic imaging, and molecular/cellular analyses were used to follow the bone graft over time. Sclerostin null mice, and mice carrying an activated form of β-catenin were evaluated to understand how elevated Wnt signaling impacted edentulous ridge height and based on these data, a biomimetic strategy was employed to combine bone graft particles with a formulation of recombinant WNT protein. Thereafter, the rate of graft incorporation was evaluated. Results. Tunneling activated osteoprogenitor cell proliferation from the periosteum. If graft particles were present, then osteoprogenitor cells attached to the matrix and gave rise to new bone that augmented edentulous ridge height. Graft particles alone did not stimulate osteoprogenitor cell proliferation. Based on the thicker edentulous ridges in mice with amplified Wnt signaling, a strategy was undertaken to load bone graft particles with WNT; this combination was sufficient to accelerate the initial step of graft incorporation. Significance. Local delivery of a WNT protein therapeutic has the potential to accelerate graft incorporation, and thus shorten the time to when the graft can support a dental implant.

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Section: Discussionmentioning

confidence: 99%

Bioactivating a bone substitute accelerates graft incorporation in a murine model of vertical ridge augmentation

Chen

Yuan

et al. 2020

Dental Materials

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“…Clinically, the lower edge of the MF appears to be a more useful reference mark in OPGs. Observing the distance from the inferior border of the mandible to the lower edge of MF and using the approximate ratio of 3:1 can help to estimate conveniently the original height of the mandible before resorption [47,48].…”

Section: Discussionmentioning

confidence: 99%

Association of type 2 diabetes mellitus with the reduction of mandibular residual ridge among edentulous patients using panoramic radiographs

Al-Jabrah¹

2011

OJST

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Objective: To evaluate the association between type 2 diabetes mellitus and the reduction of mandibular residual ridge in completely edentulous patients wearing complete dentures and to investigate the effect of gender, age and years of edentulousness/ denture wearing on ridge resorption on both groups. Methods: Seventy-two (36 men and 36 women) with a mean age 63.5 years (range of 52 to 73 years) completely edentulous denture-wearing patients were included in this study. Of these, there were 40 patients with type 2 diabetes mellitus and 32 control subjects participated in the study. Resorption in the mandibular residual ridges was assessed by using the mental foramen and the inferior border of the mandible, as they appear in panoramic radiographs, as reference points using Wical and Swoope Analysis method. Measurements were performed using "Dijite" Digital Caliper. The amount of mandibular ridge resorption was calculated and correlated with type 2 diabetes mellitus and the results were compared with control group. Differences in gender, age and years of edentulousness were investigated. Statistical analysis was performed using SPSS (V11.0). A 2-sample t-test was used to evaluate the differences in mean values of mandibular ridge resorption between diabetics and controls. Level of significance was set at 0.05. Results: The mean mandibular residual ridge resorption of all participants is 8.0 mm (26.9%), diabetic group significantly (P < 0.01) had two times more resorption compared with control group (35.8% versus 18.0%). Females recorded greater amount of resorption in diabetics 49.7% versus 21.8% (P < 0.001) and in controls 22.3% versus 13.7%, (P < 0.05) compared to males, respectively. There were no differences in both groups regarding the age of subjects and the length of time they have been edentulous and years of denture wearing. The amount of mandibular residual ridge resorption was directly related to the number of years of edentulousness. Conclusion: Completely edentulous, denture-wearing diabetics, women in particular, are at more risk to have ridge resorption than "nondiabetic" subjects. Reduced mandibular height is directly related to years of edentulousness and denture wearing with greater amount of resorption among diabetics.

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Spread of squamous cell carcinoma to the nonirradiated edentulous mandible—A preliminary report

McGregor

MacDonald²

1987

Head Neck

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The changes in the mandible and in its relationship to surrounding soft tissue structures after loss of the teeth are described; the regular presence of deficiencies in the cortical bone along the line of the occlusal ridge is emphasized. Resection specimens of squamous carcinoma of the oral cavity not treated by radiotherapy were examined where there was mandibular involvement by tumor, and showed that the main route of tumor entry into the bone was through the occlusal ridge. Subsequent perineural spread along the inferior alveolar nerve has been found to be a regular occurrence.

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Observations on the histologic features of the human edentulous ridge. Part III: Bone

Cited by 10 publications

References 14 publications

Bioactivating a bone substitute accelerates graft incorporation in a murine model of vertical ridge augmentation

Bioactivating a bone substitute accelerates graft incorporation in a murine model of vertical ridge augmentation

Association of type 2 diabetes mellitus with the reduction of mandibular residual ridge among edentulous patients using panoramic radiographs

Spread of squamous cell carcinoma to the nonirradiated edentulous mandible—A preliminary report

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