Observations on the growth of renal neoplasms.

Birnbaum, Bernard A.; Bosniak, Morton A.; Megibow, Alec J.; Lubat, E; Gordon, Richard B.

doi:10.1148/radiology.176.3.2389029

Cited by 78 publications

(47 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Neumann et al [13] studied 26 RCC lesions in VHL patients over a 5-year follow-up and described a mean growth rate of 2.6 mm/year. The growth rate of tumours in VHL disease was compared to data provided by Birnbaum et al [31] , who showed 5.2 mm/ year for sporadic RCC. At the time, the authors concluded that tumour growth of RCC in VHL disease is slower than in sporadic RCC.…”

Section: Discussionmentioning

confidence: 99%

Growth Kinetics in Von Hippel-Lindau-Associated Renal Cell Carcinoma

Jilg¹,

Neumann²,

Gläsker³

et al. 2011

Urol Int

View full text Add to dashboard Cite

Objective: To evaluate the growth kinetics of renal cell carcinoma (RCC) in von Hippel-Lindau (VHL) disease in a large trial by CT/MRI scan. VHL disease is a multisystemic disorder predisposing to renal cysts and cancer. There is a general assumption that VHL-associated RCC presents slower growth rates than sporadic RCC. Patients and Methods: We describe growth kinetics of 96 renal tumours in 64 VHL patients with analysed germline mutation (54/64 treated, 10/64 active surveillance) over a mean follow-up of 54.9 months. We calculated tumour volume, growth rate, multiplication of tumour volume per year and overall, as well as tumour volume doubling time. Results: The mean growth rate of 96 tumours was 4.4 mm/year (SD 3.2, median 4.1 mm/year), mean volume doubling time was 25.7 months (SD 20.2, median 22.2 months). We saw a median 1.4-fold increase in tumour volume per year. At treatment time point, VHL kidneys comprised 39% tumour and 15.7% cyst volume fraction. We saw no correlation between tumour size and growth parameters. Conclusion: VHL-associated RCC show large variances in tumour growth behaviour. Compared to the literature, in our study the growth rates (mm/year) of RCC in VHL disease did not differ from those of sporadic RCC. Fast tumour growth increases the risk for metastases.

show abstract

Section: Discussionmentioning

confidence: 99%

Growth Kinetics in Von Hippel-Lindau-Associated Renal Cell Carcinoma

Jilg¹,

Neumann²,

Gläsker³

et al. 2011

Urol Int

View full text Add to dashboard Cite

show abstract

“…Although not an immediate threat to life, most RCCs tend to become significantly larger over time (i.e. grow to > 3 cm diameter) [19,20]. The mean 2-year survival in patients with metastatic RCC is 20% [5].…”

Section: Introductionmentioning

confidence: 99%

Magnetic resonance imaging‐guided laser thermal ablation of renal tumours

Dick¹,

Joarder²,

Jode³

et al. 2002

BJU International

View full text Add to dashboard Cite

Objective To test the hypothesis that magnetic resonance imaging (MRI)-guided laser thermal ablation (LTA) of inoperable renal tumours is a safe, tolerable and potentially effective treatment . Patients and methods Nine patients (aged 56-81 years) with malignant renal tumours underwent percutaneous LTA under MRI guidance in a 0.5 T open magnet. Real-time colour thermal mapping was used to monitor tumour ablation, and the follow-up was with gadolinium-enhanced MRI at 6 weeks and (where appropriate) 3-4 months after the procedure. Tumour volume and percentage tumour enhancement before and after ablation were compared . The percentage of tumour ablated on real-time T1-weighted thermal maps was compared with that on gadoliniumenhanced follow-up MRI . Results The mean (range) follow-up was 16.9 (3-32) months after the first ablation. The mean tumour size did not change significantly, but the mean percentage of viable tumour decreased significantly from 73.7% before to 29.5% after ablation ( P = 0.012, Wilcoxon signed-ranks test). Thermal maps correlated moderately well with follow-up MRI in predicting the extent of tumour ablation (Pearson correlation coefficient 0.55). There were two minor and one major complication. Conclusion In this pilot study of patients unsuitable for surgery, MRI-guided LTA of renal tumours was safe, feasible (being well tolerated by the patient) and significantly reduced enhancing tumour volume by a mean of 45%.

show abstract

“…These data explain the clinical obser vation in cases of RCC in which, despite a non-surgical ap proach for various reasons, an almost proliferative arrest was noted at long-term follow-up [45]. On the other side unusual growth rates of low-stage were observed by imaging techni ques (CT, sonography) [46,47], A similiar correlation is found in other malignancies using the Ki-67 immunohistochemistry revealing a correlation between proliferation status and tumor grading, but no correlation with tumor stage [2,28,34,35]. Only a few authors have outlined the correlation of prolifera tive behavior of different malignancies and prognosis.…”

Section: Breast Cancermentioning

confidence: 69%

Proliferation Kinetics and Prognosis of Renal Cell Carcinoma

Riese¹,

Allhoff²,

Werner³

et al. 1991

Oncol Res Treat

View full text Add to dashboard Cite

The historical development of different techniques for the study of proliferative patterns of normal and malignant tissue is explained. For more than 100 years, pathologists and clinicians have attempted to clarify the prognostic impact of this tumor-biological parameter. One relevant result of these investigations is the ‘Grading-System’, a histomorphological description of tumor cell differentiation. The auto-radiographic method using tritiated thymidine (thymidine incorporation assay) detects a portion of DNA-sythesizing cells directly. However, radioactivity and long autoradiographic exposure times are the main disadvantages. DNA cytophotometry and immunohistochemical labeling are currently the most frequently used techniques for direct assessment of proliferating cells in normal and malignant renal tissue as well as in other human tumor tissues. Concerning renal cell carcinoma (RCC), our own experience and the results of the literature are compared and discussed: In contrast to tumor staging, tumor grading correlates with the tumor-specific proliferation rates. According to the present data, the measurement of the proliferative kinetics seems to be a relevant prognostic parameter for detection of high-risk patients, especially in the early stages showing identical histological findings for staging and grading.

show abstract

Observations on the growth of renal neoplasms.

Cited by 78 publications

References 0 publications

Growth Kinetics in Von Hippel-Lindau-Associated Renal Cell Carcinoma

Growth Kinetics in Von Hippel-Lindau-Associated Renal Cell Carcinoma

Magnetic resonance imaging‐guided laser thermal ablation of renal tumours

Proliferation Kinetics and Prognosis of Renal Cell Carcinoma

Contact Info

Product

Resources

About