Observations on the Effect of Riboflavin on the Oral Lesion and Dysphagia, and of Riboflavin and Brewer's Yeast on Dark Adaptation in a Case of So-Called Plummer-Vinson Syndrome

Abstract

phase of the choroidal arteritis could be observed ophthalmoscopically, and the appearances are described. THIS report concerns a male patient admitted with a PlummerVinson syndrome including dysphagia, angular stomatitis, glossitis, achlorhydria, koilonychia and hypochromic anaemia. The oral lesion and the dysphagia during the first part of observation responded to riboflavin. The finding of impaired dark adaptation (DA) later seemed to offer an opportunity for testing the possible effect of riboflavin and allied factors. These observations are part of a larger study on dark adaptation undertaken in an attempt to use this method for detecting disturbances in general metabolism, and studying quantitatively their possible relation to dietary factors.

Flavins Act as a Critical Liaison Between Metabolic Homeostasis and Oxidative Stress in the Retina

“…They also reported that patients suffering from ariboflavinosis showed resolution of their night blindness following a 10-days course of 10 mg riboflavin/day injections. The authors mention two previous reports by Pollak in 1945 andby Gordon in 1939, emphasizing the ability of riboflavin alone to improve dark adaptation (Pollak, 1945). However, supplementary evidence is lacking on these lines and needs to be validated by further research.…”