Observations on the Effect of Spironolactone in Edema Associated With Renal Disease

Lipman, Ivan J.; Greco, Federico

doi:10.1097/00000441-196304000-00003

Cited by 3 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is little evidence to suggest that amiloride is nephrotoxic; whereas, Lipman and DelGreco [66] and Neale et al [65] have suggested that spironolactone has intrinsic nephrotoxicity independent of any developed salt and water losses.…”

Section: Hemodynamic Volumementioning

confidence: 99%

Triamterene and the Kidney

Sica¹,

Gehr²

1989

Nephron

View full text Add to dashboard Cite

Triamterene (TA) is a mild ‘potassium-sparing’ diuretic usually employed in combination with other more potent diuretics in the treatment of hypertension. TA pharmacokinetics and pharmacodynamics in normal volunteers, elderly subjects and in patients with renal and hepatic dysfunction are reviewed. A variety of adverse renal effects, such as abnormalities in urinary sediment, nephrolithiasis, interstitial nephritis and acute renal failure, has been reported to occur and is also reviewed. Of particular concern with the increased availability of ‘over-the-counter’ nonsteroidal anti-inflammatory medications (NSAID) is the adverse interaction between TA and NSAID which may culminate in acute renal failure. Although a rare occurrence, the clinician should be aware of potential adverse reactions associated with the use of TA.

show abstract

Section: Hemodynamic Volumementioning

confidence: 99%

Triamterene and the Kidney

Sica¹,

Gehr²

1989

Nephron

View full text Add to dashboard Cite

show abstract

“…the presence of renal failure serum potassium levels may rise to dangerous levels (Lipman and del Greco, 1963). 2.…”

mentioning

confidence: 99%

Diuretics1

Anderton

Kincaid‐Smith

1971

Drugs

View full text Add to dashboard Cite

The successful use of diuretics depends upon a knowledge of their mode of action, their potency, and their side-effects. The four basic groups of diuretics which cover most situations are: (i) the thiazides, (ii) ethacrynic acid or frusemide, (iii) spironolactone or triamterene, (iv) mannitol.The thiazides have a moderate diuretic action and are useful in any oedematous state where a gradual removal of salt and water is required. Mild to moderate cardiac, cirrhotic, and renal oedema respond well to thiazide administration, and the thiazides are useful in systemic hypertension, diabetes insipidus, and in the treatment of hypertension and oedema associated with pregnancy.

show abstract