Observations on the Chromatographic Heterogeneity of Normal Adult and Fetal Human Hemoglobin: A Study of the Effects of Crystallization and Chromatography on the Heterogeneity and Isoleucine Content

Allen, David W.; Schroeder, W. A.; Balog, Joan

doi:10.1021/ja01540a030

Cited by 422 publications

(125 citation statements)

References 5 publications

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“…Following older works of lesser impact, the heterogeneity of human hemoglobin (Hb) has been clearly demonstrated for the first time by Allen et al in 1958 using cation exchange chromatography [1] . Other groups confirmed this heterogeneity and established the identity between Hb fractions separated by chromatography and by electrophoresis [2,3] .…”

Section: The Times Of Pioneers and Discoveriesmentioning

confidence: 98%

A history of HbA_1c through Clinical Chemistry and Laboratory Medicine

Gillery¹

2012

Clinical Chemistry and Laboratory Medicine (CCLM)

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HbA 1c was discovered in the late 1960s and its use as marker of glycemic control has gradually increased over the course of the last four decades. Recognized as the gold standard of diabetic survey, this parameter was successfully implemented in clinical practice in the 1970s and 1980s and internationally standardized in the 1990s and 2000s. The use of standardized and well-controlled methods, with well-defined performance criteria, has recently opened new directions for HbA 1c use in patient care, e.g., for diabetes diagnosis. Many reports devoted to HbA 1c have been published in Clinical Chemistry and Laboratory Medicine (CCLM) journal. This review reminds the major steps of HbA 1c history, with a special emphasis on the contribution of CCLM in this field.

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Section: The Times Of Pioneers and Discoveriesmentioning

confidence: 98%

A history of HbA_1c through Clinical Chemistry and Laboratory Medicine

Gillery¹

2012

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…First recognized as a component of human haemoglobin by Allen [5] in the late 1950s, HbA 1c was not associated with diabetes until a decade later, when Rahbar [6,7] identified an 'abnormal' haemoglobin in people with diabetes, which was subsequently found to be HbA 1c . Following this discovery, a number of small studies were conducted to see if HbA 1c levels correlated with blood glucose concentrations [8,9].…”

Section: What Is Hba 1c ?mentioning

confidence: 99%

Current controversies in the use of haemoglobin A_1c

Hare

Shaw

Zimmet

2012

Journal of Internal Medicine

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Abstract. Hare MJL, Shaw JE, Zimmet PZ (Baker IDI Heart and Diabetes Institute, Melbourne, Vic.; and Monash University, Melbourne, Vic.; Australia). Current controversies in the use of haemoglobin A 1c (Review). J Intern Med 2012;271: 227-236.Haemoglobin A 1c (HbA 1c ) has recently been adopted by the World Health Organization into its recommended criteria for diabetes diagnosis. Much debate continues regarding the relative benefits and potential disadvantages surrounding the use of HbA 1c for this purpose. There is a lack of consensus as to whether this alteration to the definition of diabetes is a step forward or whether it could add further confusion and ambiguity to the debate on the method and criteria for the diagnosis of this globally important disease. This review provides a comprehensive overview of the current issues surrounding how HbA 1c is measured and reported; and of the evidence for and against its use in diagnosis.

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“…They reported the presence of a negatively charged component of haemoglobin in human red blood cells (Allen et al 1958). This was a variant of glycated haemoglobin HbA 1 .…”

Section: Historical Background Of Glycationmentioning

confidence: 99%

Glycation research in amino acids: a place to call home

2010

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This is an introduction to a collection of review articles by leading investigators in the field of protein glycation research, see following articles in this issue. With this we launch a section of this journal now established for presentation of research results, reviews and commentaries on protein glycation and related topics. Glycation is the spontaneous, non-enzymatic reaction of protein with saccharides and saccharide derivatives. Although studied in the modern scientific era for over 100 years, its importance in the biology, medicine, food and nutrition, pharmacology and toxicology, and technological processing remains intriguingly undisclosed. In this section of amino acids, research on glycation is a qualifier for publication. Glycation research now has a place to call home.

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Observations on the Chromatographic Heterogeneity of Normal Adult and Fetal Human Hemoglobin: A Study of the Effects of Crystallization and Chromatography on the Heterogeneity and Isoleucine Content

Cited by 422 publications

References 5 publications

A history of HbA_1c through Clinical Chemistry and Laboratory Medicine

A history of HbA_1c through Clinical Chemistry and Laboratory Medicine

Current controversies in the use of haemoglobin A_1c

Glycation research in amino acids: a place to call home

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Observations on the Chromatographic Heterogeneity of Normal Adult and Fetal Human Hemoglobin: A Study of the Effects of Crystallization and Chromatography on the Heterogeneity and Isoleucine Content

Cited by 422 publications

References 5 publications

A history of HbA1c through Clinical Chemistry and Laboratory Medicine

A history of HbA1c through Clinical Chemistry and Laboratory Medicine

Current controversies in the use of haemoglobin A1c

Glycation research in amino acids: a place to call home

Contact Info

Product

Resources

About

A history of HbA_1c through Clinical Chemistry and Laboratory Medicine

A history of HbA_1c through Clinical Chemistry and Laboratory Medicine

Current controversies in the use of haemoglobin A_1c