Observations on the Anticatabolic Effect of Xylitol in the Posttraumatic Phase

Schultis, K; Geser, C. A.

doi:10.1007/978-3-642-46191-0_39

Cited by 4 publications

(4 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Urinary losses up to this rate are negligible [10,12,14,19,33,35], Metabolically healthy persons are able to meet the administered glucose load by an ap parently steady new production of insulin, and Seltzer and H arris [27] as well as G raber et al [8] have shown that even a constant glucose infusion lasting up to 7 days was unable to exhaust insulin reserve. It is of interest that results showing glucose to be metabolized to a lesser degree than other hexoses were mainly derived from surgical patients during the postoperative period [1,22,30], The stress condition due to surgical trauma, favoring glyco lysis and gluconeogenesis, was held responsible for the above-cited effect [26], Certainly, glucose should not be routinely administered to diabetics.…”

Section: Discussionmentioning

confidence: 99%

“…Concerning this polyol, a brief summary will be presented which is based on the investigations of others [5,6,16,26,28], as such studies have not been performed by us yet. Although the pentose phosphate pathway pro duces only a few grams of xylitol daily [16], enzymes metabolizing xylitol are said to adapt to parenteral xylitol loading, thus causing an increase in this polyol utilization [16].…”

Section: Xylitolmentioning

confidence: 99%

See 1 more Smart Citation

The Comparative Metabolism of Carbohydrates Administered Intravenously

Heuckenkamp¹,

Zöllner²

1972

Ann Nutr Metab

View full text Add to dashboard Cite

Glucose, fructose and galactose have been administered intravenously over several hours to healthy persons; different administration rates were used. These sugars were measured enzymatically in serum and urine. Moreover, insulin (IMI) and uric acid were also determined (the latter for fructose only). Glucose and fructose are equally well utilized, galactose is unsuited for parenteral feeding due to caloric restriction and toxic side-effects. High-fructose loads (1.5 g/kg body weight/h) were followed by a significant rise of serum uric acid, lower infusion rates did not show alterations of uric acid, however. All hexoses are followed by an elevation of plasma insulin, although the increase during galactose and fructose infusions is only moderate in comparison with glucose. Finally, the above-mentioned results are compared with xylitol, a pentose frequently used for parenteral nutrition.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Xylitolmentioning

confidence: 99%

The Comparative Metabolism of Carbohydrates Administered Intravenously

Heuckenkamp¹,

Zöllner²

1972

Ann Nutr Metab

View full text Add to dashboard Cite

show abstract

“…Its effect on the human B-cell is not clearly assessed, since IRI response is not uniform [22,25]. Xylitol seems to be relatively non-toxic [3,27], although complications after its clinical use have been reported [27].…”

Section: Diabetotogiamentioning

confidence: 99%

Metabolism and oxidation of U-14C-glucose, xylitol, fructose and sorbitol in the fasted and in the streptozotocin-diabetic rat

Keller

Froesch

1971

Diabetologia

View full text Add to dashboard Cite

Summary. 1. 24-h-fasted rats exhaled 35--37% of i.v. administered loads of labelled glucose, xylitol and fructose, and 20% of a sorbitol load as ir within a period of six hours. 2. Streptozotocin-diabetic rats exhaled under similar conditions only 11--18~ of these substrates as laCO 2. The rate of glucose oxidation was similar in both groups of animals when a correction for the different glucose pool size was applied, It is concluded that glucose oxidation to 14C0e takes place mainly in tissues which are not sensitive to insulin. 3. Urinary excretion of all substrates was 39--55% of the given dose in diabetic rats. The large difference of urinary carbon-14 between fasted and diabetic rats was due to the excretion of glucose-i~C by the diabetic rats. 4. Six hours after the administration of all four substrates, similar amounts of carbon-14 were recovered in serum, serum osazones, liver glycogen and total lipids and diaphragm glycogen within each group of animals. It is concluded that the similarities of the metabolism of all substrates is due to the rapid conversion of the substitute sugars to glucose.

show abstract

“…Xylitol is particularly advantageous in the postoperative period. Schultis and Geser (1969), and also Yoshikawa (1969) have shown that the administration of xylitol normalized the utilization of glucose in the posttraumatic period and the balances of ketone bodies and the nitrogen losses will be reduced.…”

mentioning

confidence: 99%

Energy Requirements and Supply in Catabolic Patients

Halmágyi¹

1976

Ann Nutr Metab

View full text Add to dashboard Cite

Observations on the Anticatabolic Effect of Xylitol in the Posttraumatic Phase

Cited by 4 publications

References 10 publications

The Comparative Metabolism of Carbohydrates Administered Intravenously

The Comparative Metabolism of Carbohydrates Administered Intravenously

Metabolism and oxidation of U-14C-glucose, xylitol, fructose and sorbitol in the fasted and in the streptozotocin-diabetic rat

Energy Requirements and Supply in Catabolic Patients

Contact Info

Product

Resources

About