Observations on Leukoderma Acquisitum Centrifugum

The Use of Topical Proteolytic Enzymes in the Treatment of Post‐thrombotic Leg Ulcers

“…Similarly, topical non-fluorinated steroids have their advocates and critics but their inclusion in ointment formulations as a means of reducing surface inflammation is probably useful. Reports on the inclusion of proteolytic enzymes have been published (Cornbleet et 01., 1959;Cornbleet and Chesrow, 1960;Irgang, 1960;Levine et 01., 1959;Lucas, 1960;Morani et 01., 1960). Their pharmacological action in cleansing the crater bed of an ulcer has advantages over physical debridement: nursing time is saved and the patient appreciates the painless removal of slough and necrotic material.…”