OBSERVATIONS ON (i) SWEAT SODIUM LEVELS IN RELATION TO CHRONIC RESPIRATORY DISEASE IN ADULTS AND (ii) THE INCIDENCE OF RESPIRATORY AND OTHER DISEASE IN PARENTS AND SIBLINGS OF PATIENTS WITH FIBROCYSTIC DISEASE OF THE PANCREAS

Anderson, Charlotte M.; Freeman, Mavis; Allan, Jean L.; Hubbard, Lois

doi:10.5694/j.1326-5377.1962.tb27044.x

Cited by 21 publications

(2 citation statements)

References 10 publications

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“…We also included pulmonary function tests and sweat tests by the pilocarpine iontophoresis method [16]. The findings in sweat are similar to those of other investigators [17,181 and showed no significant differences in the parents and control groups. A recent study [19] in which 132 parents and 118 controls were compared for various acquired diseases, particularly of the respiratory and gastrointestinal tract, confirmed the above.…”

Section: By Harry Shwachman and Louis Kopitosupporting

confidence: 54%

Some Genetic Considerations in Cystic Fibrosis. A Study of Nail and Sweat Sodium in Two Sibships1

Shwachman

Kopito

1967

Acta Paediatrica

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Summary The rationale for studying tissue that stores sodium as it occurs in nails is presented. The results of our studies on the concentration of sodium in 242 patients with C.F., 63 healthy children, 171 parents of children with C.F., 51 healthy adults and 184 siblings of patients with cystic fibrosis are presented. The elevated nail sodium concentration was detected in over 95 % of the patients with C.F. and in no patient with C.F. was the value less than 80 mEq/Kg. Seven out of 8 children born to parents, one of whom had C.F., showed elevated nail sodium. By definition these healthy children are the only presently recognized heterozygotes in infancy. The sibling group showed a wide range of values suggesting the possibility of indicating the heterozygote. The nail and sweat sodium results in three generations of two selected sibships is shown in graphic form. Variations are noted which indicate that this type of study does not select the heterozygote for the gene of cystic fibrosis. The usefulness of the measurement of nail sodium is stated. It is hoped that this report will stimulate others to seek other methods for detecting the heterozygote.

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Section: By Harry Shwachman and Louis Kopitosupporting

confidence: 54%

Some Genetic Considerations in Cystic Fibrosis. A Study of Nail and Sweat Sodium in Two Sibships1

Shwachman

Kopito

1967

Acta Paediatrica

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“…Alternatively, the data have raised the possibility of a detectable heterozygote state. On the other hand, reports of other authors [2] are in contrast with these findings. The variability of the results and, in some cases, the inadequacy of the controls led to the present search for a consistent characteristic which might distinguish the heterozygote carrier of cystic fibrosis from the non-carrier.…”

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confidence: 63%

Anamnesis, Sweat Electrolyte and Pulmonary Function Studies in Parents of Patients with Cystic Fibrosis of the Pancreas1

et al. 1963

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SUMMARY One hundred and two parents of children with cystic fibrosis and 52 control parents were studied with regard to physical examination of the chest, personal and family history, sweat electrolytes and pulmonary function tests. The physical examination of the chest was negative in all parents. When the C.F. parents were compared with the control group, no significant differences could be found in the personal and family histories of chronic cough, allergy, gastrointestinal disorders (ulcer and cholelithiasis) and diabetes. The concentration of sodium, chloride, and potassium in the sweat (produced by iontophoresis) was similar in the two groups of parents. The pulmonary function tests (vital capacity, timed vital capacity, peak expiratory flow rate, maximal breathing capacity, and nitrogen washout) showed no significant differences between the two groups of parents. This study provides no evidence that cystic fibrosis is inherited as a dominant disease. By the methods used no particular characteristics were found which could differentiate the heterozygote carrier of cystic fibrosis from the non‐carrier.

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Elevated Sweat Sodium and Chloride in Adult Without Cystic Fibrosis

GUP¹

1963

Arch Intern Med

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OBSERVATIONS ON (i) SWEAT SODIUM LEVELS IN RELATION TO CHRONIC RESPIRATORY DISEASE IN ADULTS AND (ii) THE INCIDENCE OF RESPIRATORY AND OTHER DISEASE IN PARENTS AND SIBLINGS OF PATIENTS WITH FIBROCYSTIC DISEASE OF THE PANCREAS

Cited by 21 publications

References 10 publications

Some Genetic Considerations in Cystic Fibrosis. A Study of Nail and Sweat Sodium in Two Sibships1

Some Genetic Considerations in Cystic Fibrosis. A Study of Nail and Sweat Sodium in Two Sibships1

Anamnesis, Sweat Electrolyte and Pulmonary Function Studies in Parents of Patients with Cystic Fibrosis of the Pancreas1

Elevated Sweat Sodium and Chloride in Adult Without Cystic Fibrosis

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