Observations on Digitalis Intoxication

Rodensky, Paul L.

doi:10.1001/archinte.1961.03620080003002

Cited by 113 publications

(18 citation statements)

References 74 publications

(1 reference statement)

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“…In this circumstance, the term 'PAT with block' has been used. 25 The importance of PAT with block induced by digitalis was emphasized because the arrhythmia was often found in serious underlying heart disease with a high mortality.22' 32 Although the frequent occurrence of digitalis-induced PAT with block is emphasized repeatedly, its average incidence is only about 10%4 of the total digitalis-induced cardiac arrhythmias.2' 3,11,12,14,[22][23][24][25][26][27][28] This author2 found twelve instances of atrial tachycardia with A-V block (Fig. 3) and three instances without A-V block among 180 cases with digitalis intoxication.…”

Section: Cardiac Manifestationsmentioning

confidence: 99%

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Digitalis intoxication

Chung

1972

Postgraduate Medical Journal

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Section: Cardiac Manifestationsmentioning

confidence: 99%

“…The average incidence of second degree A-V block by different series is estimated to be 11.2, 3,11,12,14,[22][23][24][25][26][27][28] Among second degree A-V block, Wenckebach (Mobitz type-I) A-V block is more common than 2: 1 A-V block (Fig. 12).…”

Section: Cardiac Manifestationsmentioning

confidence: 99%

Digitalis intoxication

Chung

1972

Postgraduate Medical Journal

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“…Renal function as judged by mean blood urea nitrogen concentration was also intermediate. INTRODUCTION Clinical use of digitalis glycosides is complicated by a reported incidence of cardiac toxicity varying from 7 (1) to 20% (2) in hospitalized patients receiving these drugs.…”

mentioning

confidence: 99%

Digoxin intoxication: the relationship of clinical presentation to serum digoxin concentration

Smith¹,

Haber²

1970

J. Clin. Invest.

320

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A B S T R A C T A radioimmunoassay for serum digoxin concentration has been used to study the interrelationships of circulating levels of the drug and various factors in the clinical setting in 48 hospitalized patients with cardiac rhythm disturbances due to digoxin intoxication. 131 patients on maintenance doses of digoxin without toxicity and 48 patients with equivocal evidence of digoxin excess were also studied and compared with the toxic group.Patients with cardiac rhythm disturbances due to digoxin intoxication tended to be older and to have diminished renal function compared with the nontoxic group; body weight, serum potassium concentration, underlying cardiac rhythm, and nature of cardiac disease were not significantly different for the groups as a whole. Despite comparable mean daily digoxin dosages, digoxin intoxicated patients had a mean serum digoxin concentration of 3.7 ±1.0 (SD) ng/ml, while nontoxic patients had a mean level of 1.4 ±0.7 ng/ml (P < 0.001). 90% of patients without evidence of toxicity had serum digoxin concentrations of 2.0 ng/ml or less, while 87% of the toxic group had levels above 2.0; the range of overlap between the two groups extended from 1.6 to 3.0 ng/ ml. Patients with atrioventricular block as their principal toxic manifestation had a significantly lower mean serum digoxin concentration than those in whom ectopic impulse formation was the chief rhythm disturbance.Patients with equivocal evidence of digoxin excess had received comparable daily maintenance doses of digoxin but had a mean serum concentration of 1.9 +0.8 ng/ml, intermediate between those of the nontoxic (P < 0.005) and toxic (P < 0.001) groups. Renal function as judged by mean blood urea nitrogen concentration was also intermediate.

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“…Par la bouche, il est recommandé de prescrire 2 à 3 g toutes les trois à six heures [40] ou 5 g d'emblée puis 2 g toutes les quatre heures dans un jus d'orange [109] et d'éviter l'administration de tablettes qui sont souvent mal solubles et indigestes. Ce traitement est bénéfique si on est en présence d'une baisse de potassium dans l'organisme, inutile, voire dangereux, si les réserves de potassium sont normales [40, 42, 48, 49, li, 109, 145].…”

Section: Le Traitement De L'intoxication Digitaliqueunclassified

Diagnostic de l’intoxication digitalique et son traitement

Ferrero¹

1967

Cardiology

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Observations on Digitalis Intoxication

Cited by 113 publications

References 74 publications

Digitalis intoxication

Digitalis intoxication

Digoxin intoxication: the relationship of clinical presentation to serum digoxin concentration

Diagnostic de l’intoxication digitalique et son traitement

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