Observations on Cadmium Damage and Repair in Rat Testes and the Effects on the Pituitary Gonadotrophs

Allanson, M.; Deanesly, Ruth

doi:10.1677/joe.0.0240453

Cited by 32 publications

(9 citation statements)

References 2 publications

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“…selective destructive effect of cadmium on the testis of the rat and mouse have since been confirmed by Meek (1959), Kar & Das (1960), Gunn, Gould & Anderson (1961), Allanson & Deanesly (1962), Chiquoine (1964), Mason, Brown, Young & Nesbit (1964) and others. During studies on the induction of interstitial cell tumours of the testis by cadmium (Gunn, Gould & Anderson, 1963), we noted that cadmium failed to cause any degree of damage to the testis of the BALB/c mouse.…”

mentioning

confidence: 80%

Strain Differences in Susceptibility of Mice and Rats to Cadmium-Induced Testicular Damage

Gunn¹,

Gould²,

Anderson³

1965

Reproduction

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The observations of Pa\l=r%v\\l=i' \zek& Zahor (1956) and Pa\l=r%v\\l=i' \zek (1957a, b) Zahor, 1956; Pa\l =r%v\\l =i ' \zek,1957a, b;Meek, 1959;Kar & Das, 1960;Gunn et al., 1961). Animals were killed 48 hr after the injection of cadmium.A total of 130 mature (8-week-old) male mice, composed of eighteen different inbred strains and one random bred strain (CD-1, derived from HaM/ICR Swiss mi ce)\s=deg\ were tested. Following the administration of CdCl2, necrosis was seen consistently in the random-bred CD-1 strain, as well as in ten of the inbred strains: AKR/J, CBA/J, C57BR/cdJ, C57L/J, C58/J, DBA/1J, DBA/2J, RF/J, SWR/J and 129/J. The SJL/J strain gave a variable response. Experiments with lower doses revealed that the amount of cadmium needed to produce minimal testicular damage varied within these susceptible strains.Seven of the inbred strains of mice showed no microscopic evidence of testicular damage from CdCl2: A/HeJ, A/J, BALB/cJ, C3H/HeJ, C3HeB/FeJ, C57BL/6J and C57BL/10J. Increasing the dose of cadmium to the lethal range still did not produce a testicular effect.

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mentioning

confidence: 80%

Strain Differences in Susceptibility of Mice and Rats to Cadmium-Induced Testicular Damage

Gunn¹,

Gould²,

Anderson³

1965

Reproduction

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“…Changes in the gonadotrophic cells of the adenohypophysis, have been described as a result of 'cadmium castration' (Allanson & Deanesly, 1962;Girod, 1964;David & Ramaswami, 1971 …”

Section: Decidua and Placentaementioning

confidence: 99%

Possible Mechanisms of Cadmium Fetotoxicity in Golden Hamsters and Mice: Uptake by the Embryo, Placenta and Ovary

Dencker¹

1975

Reproduction

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Summary. Pregnant golden hamsters and mice of different gestational ages were injected intravenously with 109CdCl2. The whole animal or the uterus and embryos were submitted to autoradiography. Cadmium administered on the 8th day accumulated in the primitive gut of the embryos. No cadmium was detected in the embryos after administration on or after the 9th day (hamster) and 11th day (mouse). This finding can be explained by the ability of cadmium to pass from the yolk-sac cavity into the primitive gut (where it is absorbed) before the closure of the vitelline duct but not later. This uptake by the embryo might explain the severe malformations produced by cadmium given on the 8th day as compared with the 9th day in the hamster. Cadmium is also heavily accumulated in the decidua (mainly the antimesometrial part), the yolk sac, the ectoplacental cone, and later in the chorioallantoic placenta\p=m-\possiblydisturbing the maternal-embryonic relationship and fetal nutrition. A high accumulation in the CL and the follicles and in the pituitary may also disturb reproductive function.

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“…Gunn, Gould & Anderson (1963 a) showed that, after cadmium administration, avascular necrosis occurs in the testis, and they suggested that the necrosis may be due to interference with some enzymic system, possibly cadmium-zinc dependent, which controls the permeability of the endothelium in this vascular area. After cadmium damage, Leydig cell regeneration from the tunica albugínea has been described (Parizek, 1960;Allanson & Deanesly, 1962) and neoplasia of the regenerated Leydig cells has been observed (Gunn, Gould & Anderson, 1963&;Roe, Dukes, Cameron, Pugh & Mitchley, 1964). The present investigation deals with the biosynthesis in vitro of androst-4-ene-3, 17-dione (androstenedione) and testosterone from 3/?-hydroxypregn-5-en-20-one (pregnenolone) by testes and adrenals from rats up to 5 months after cadmium poisoning.…”

Section: Introductionmentioning

confidence: 99%

Androgen Synthesis by the Testes and Adrenal Glands of Rats Poisoned With Cadmium Chloride

Favino¹,

Baillie²,

Griffiths³

1966

Journal of Endocrinology

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SUMMARY Androgen synthesis after administration of cadmium chloride to rats has been studied histologically, histochemically and biochemically. Incubation in vitro of testicular tissue removed 10 days after cadmium administration revealed markedly decreased testosterone synthesis. After 100 and 150 days, testosterone synthesis in vitro had increased progressively and significantly, but there was a marked decrease in the testosterone: androstenedione ratio. Surviving Leydig cells, giving typical histochemical reactions for 3β-, 16β- and 17β-hydroxysteroid dehydrogenase, were observed under the tunica albuginea immediately after cadmium poisoning. Fifty days after the cadmium treatment, mesenchymal cells, giving a histochemical 3α- and 16α-hydroxysteroid dehydrogenase reaction, but no other hydroxysteroid dehydrogenase reaction of normal Leydig cells, grew into the testes from the tunica albuginea. Weight, citric acid and fructose contents of seminal vesicles of cadmium-treated rats fell nearly to castration levels, but showed some degree of recovery thereafter. Studies in vitro on adrenal tissue from cadmium-poisoned rats suggested that the rate of testosterone biosynthesis from pregnenolone was increased.

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Observations on Cadmium Damage and Repair in Rat Testes and the Effects on the Pituitary Gonadotrophs

Cited by 32 publications

References 2 publications

Strain Differences in Susceptibility of Mice and Rats to Cadmium-Induced Testicular Damage

Strain Differences in Susceptibility of Mice and Rats to Cadmium-Induced Testicular Damage

Possible Mechanisms of Cadmium Fetotoxicity in Golden Hamsters and Mice: Uptake by the Embryo, Placenta and Ovary

Androgen Synthesis by the Testes and Adrenal Glands of Rats Poisoned With Cadmium Chloride

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