1936
DOI: 10.1152/ajplegacy.1936.117.1.175
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Observations on a Substance in Pancreas (A Fat Metabolizing Hormone) Which Permits Survival and Prevents Liver Changes in Depancreatized Dogs

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Cited by 108 publications
(5 citation statements)
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“…This fatty degeneration is not prevented by either choline or by lipocaic preparations made according to the method of Dragstedt et al (1936). This fatty degeneration is not prevented by either choline or by lipocaic preparations made according to the method of Dragstedt et al (1936).…”
Section: Paralysis and Yellow Liversmentioning
confidence: 88%
“…This fatty degeneration is not prevented by either choline or by lipocaic preparations made according to the method of Dragstedt et al (1936). This fatty degeneration is not prevented by either choline or by lipocaic preparations made according to the method of Dragstedt et al (1936).…”
Section: Paralysis and Yellow Liversmentioning
confidence: 88%
“…The defect in clearing in alloxan-diabetic rats could also be corrected by feeding of Lipormone, a purified preparation of lipocaic of Dragstedt. 35 At present it is not possible to state whether the two substances are identical. However, since it has been observed in this laboratory that destruction of acinous tissues of the pancreas did not reduce the clearing activity of postheparin plasma, 36 the islets seem to be the source of this factor.…”
Section: Discussionmentioning
confidence: 99%
“…In later years, Lombroso's observations were extended, and, since 1924, it has been known that the development of fatty livers in insulin-treated depancreatized dogs can be prevented by the administration of raw pancreas. When it was recognized that the activity of pancreas fractions upon the liver could not be accounted for by their choline and methionine content, an antifatty liver factor was postulated and called "lipocaic" by Dragstedt et al (22,23) and anti-fatty liver factor (AFL) by Chaikoff and Entenman (16). The presence of such a lipotropic pancreatic factor has been debated for more than 50 years.…”
Section: Racial Hygiene and The Brain Drain In Physiologymentioning
confidence: 99%