Observations on a Class of Free Radicals Derived from Aromatic Compounds

Lipkin, David; Paul, Donald E.; Townsend, Jonathan; Weissman, S. I.

doi:10.1126/science.117.3046.534

Cited by 83 publications

(16 citation statements)

References 10 publications

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“…Some researchers have acknowledged that free radicals participate in carcinogenic activity [4,5]. Lipkin et al [5] suggested that the carcinogenic activities of some large ring structures, together with mild reductive agents, could create negative ion-free radicals. Non-carcinogenic hydrocarbons, such as naphthalene, have also been shown to require very strong reducing agents before such radicals can be formed.…”

Section: Epr Study Of Free Radicals and Carcinogenic Activitymentioning

confidence: 99%

Biomedical EPR

Çalişkan¹,

Çalişkan²

2019

Topics From EPR Research

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Free radicals may participate in biological processes. An enzymatic dehydrogenation involved free radical intermediates. The oxidations of organic molecules, although they are bivalent, proceed in two successive steps, the intermediate state being a free radical. In an attempt to correlate the action of such a variety of carcinogenic agents as sodium hydroxide, ultraviolet and ionizing radiations and thousands of organic compounds, a free radical intermediate always suggests itself. Electron paramagnetic resonance (EPR) has brought sufficient sensitivity and discrimination to observe free radical intermediates directly in many of these reactions. EPR is aided by an increased sensitivity in many cases and has made a much greater contribution by distinguishing among paramagnetic ions, odd molecules and free radicals.

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Section: Epr Study Of Free Radicals and Carcinogenic Activitymentioning

confidence: 99%

Biomedical EPR

Çalişkan¹,

Çalişkan²

2019

Topics From EPR Research

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show abstract

“…The red complex formed during the sodium catalysed polymerisation of styrene has been shown to be paramagnetic and the stable radical ion (C,H,*CH=CH,)-has been postulated. 320 Radiation Chemistry.-Primary Processes.-Lindholm 321 has carried out an interesting investigation of the ionisation of hydrogen sulphide by bombardment with electrons and a variety of atomic ions. The relative proportions of the ions H,S+ : HS+ : Si from electron bombardment were 100 : 43 : 46.…”

Section: -289mentioning

confidence: 99%

General and physical chemistry

Carson¹,

Collinson²,

Cruikshank³

et al. 1953

Annu. Rep. Prog. Chem.

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“…Berthelot first discovered as early as 1867 that when naphthalene was fused with metallic potassium, a black addition product was formed. 20 Later, Weissman and co-workers demonstrated that the black solution was caused by the formation of a naphthalene radical anion via the electron transfer process, 21,22 and the reduction potential of the naphthalene radical anion is close to that of alkali metals. 23 Previous reports have shown that introducing nitrogen atoms or electron-withdrawing groups into the polycyclic aromatic hydrocarbon (PAH) aids in the formation of stable radical anions.…”

Section: Introductionmentioning

confidence: 99%