Observations on a Case of Huntington's Chorea.

Evans, Jeff

doi:10.1016/s0140-6736(01)79941-2

Cited by 4 publications

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“…Wendt (1959), the definition proposed by Panse (1942) has been adopted in the present study; onset has been dated from the first appearance of psychiatric or neurological signs attributed retrospectively to Huntington's chorea. Providing that ages of onset were recorded to within three years and unless they had resided in different isothermal regions (defined below), subjects were drawn from all the descriptions in the source references cited in Appendix III of Brackenridge (1972) with the following additions: Althaus (1880), MacLeod (1881), King (1885), Diller (1889), Phelps (1892), Collins (1898), Evans (1908), Muller (1903), Strumpell (1908, Bahr (1912), Seip (1928), Casper (1930), von Santha (1931), Buck (1934), Kloos (1938), Lion and Kahn (1938), Chamberlain (1943), Cronin (1943), Reisner (1944), Laane (1951), Major (1951), Leese et al (1952), Shiman (1954), Souder (1954), Saetra (1958), Mackenzie-Van Der Noordaa (1960), Oltman and Friedman (1961), Muller-Kuppers and Stenzel (1963), Brothers (1964), Sourkes et al (1965), Calkins and Van Allen (1967), Korenyi and Whittier (1967), Starr (1967), Finn (1970), Guercio (1970), Ordofiez (1971), Fau et al (1971), and Wallace and Hall (1972).…”

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Effect of climatic temperature on the age of onset of Huntington's chorea

Brackenridge

1974

Journal of Neurology, Neurosurgery & Psychiatry

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SYNOPSIs The ages of 1,403 subjects at onset of Huntington's chorea were drawn from the literature and related to the mean annual, January, and July temperatures of their place of residence. When the data were converted into mean annual, winter, and summer isotherms covering a range of 10°F (5*6°C), there was a statistically significant decrease in age of onset as the temperature increased. Over the ranges studied, winter temperatures exerted a stronger effect than summer temperatures. To reduce interference by ethnic factors, the analysis was repeated on North American subjects with similar results. It is suggested that repeated infections may provoke chorea and that the observed lowering of the age of onset is associated with increased susceptibility to infection on passing from cold to warm climates.

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Effect of climatic temperature on the age of onset of Huntington's chorea

Brackenridge

1974

Journal of Neurology, Neurosurgery & Psychiatry

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Neuropathology

Hayden¹

1981

Huntington’s Chorea

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A genetic and statistical study of some sex‐related factors in Huntington's disease

Brackenridge

1971

Clinical Genetics

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From an analysis of published sibships containing at least one subject with Huntington's disease, evidence was obtained from segregation ratios derived from several hypothetical modes of ascertainment that single‐membered sibships are less likely to be recorded than those containing at least two affectcd persons and that the probability of reporting a sibship is proportional to the number of affected siblings. Familial sex‐limitation and partial sex‐linkage could not be detected in the sample. Investigation of parental and grandparcntal lines ol transmission revealed that patrilineal descent predominated for all subjccts except unaffected daughters. Mcan ages at onset and death wcrc independent of the 5ex of the subject or the tranymitting parent. On the other hand, the offspring of affected males suffered from the disorder for a shorter period of time than offspring of affccted females. Ages at onsct and death varied significantly from generation to generation, presumably because parents are ofren ascertained through their children in the literature and the phenomenon of anticipation thereby arises. Onset age was earlier in members of small sihships than in those of large sibships. This could be related to the earlier onset age of parents producing small families compared with those producing large families.

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Observations on a Case of Huntington's Chorea.

Cited by 4 publications

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Effect of climatic temperature on the age of onset of Huntington's chorea

Effect of climatic temperature on the age of onset of Huntington's chorea

Neuropathology

A genetic and statistical study of some sex‐related factors in Huntington's disease

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