Observations of the Cardiovascular System in Thyroid Disease

Kerr, William J.

doi:10.1001/archinte.1923.00110150097007

Cited by 23 publications

(3 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our data indicate that heart muscle responds to moderate (therapeutic) doses of digitalis in hypothyroidism as well as hyperthyroidism, thus supporting a few clinical observations that the failing myocardium in hypothyroidism 18 and hyperthyroidism 19 "" 21 is, in fact, strengthened by digitalis. Regarding the digitalis requirement in treatment of atrial fibrillation in thyroid disorders reference should be made to the experimental work by Frye and Braunwald.…”

Section: Discussionsupporting

confidence: 86%

See 1 more Smart Citation

Comparison of the Action of Ouabain on the Heart in Hypothyroid, Euthyroid and Hyperthyroid Dogs

Rosén

Moran

1963

Circulation Research

View full text Add to dashboard Cite

Ouabain-induced changes in cardiac contractile force and differences in the amount of ouabain required to induce arrhythmias and to produce death were evaluated in normal, thyroidectomized and thyroxine-treated dogs. It was found, that ouabain, following alterations in thyroid function, still substantially augmented cardiac contractile force in anesthetized open-chest dogs. In both the hypothyroid and the hyperthyroid animals a moderate dose of ouabain produced an increase in contractile force of approximately the same extent as in the euthyroid animals, although of slower onset in the hypothyroid dogs. Larger doses of ouabain caused a smaller positive inotropic response. in hyperthyroid dogs than in euthyroid and hypothyroid animals. Changes in thyroid function increased the arrhythmia-producing and the lethal dose of ouabain, which in the hyperthyroid dogs may have been due to the markedly elevated heart rate.

show abstract

Section: Discussionsupporting

confidence: 86%

“…The animals were given food ad libitum. Studies were done after nine to eleven days of treatment (18)(19)(20)(21)(22)(23)(24) hours after the last thyroxine injection). Serum potassium levels were determined with a flame photometer before and at the conclusion of the treatment.…”

Section: Methodsmentioning

confidence: 99%