The observed relationships between anomalous Antarctic sea ice concentration (SIC) and the leading patterns of Southern Hemisphere (SH) large-scale climate variability are examined as a function of season over 1980-2008. Particular emphasis is placed on 1) the interactions between SIC, the southern annular mode (SAM), and El Niñ o-Southern Oscillation (ENSO); and 2) the contribution of these two leading modes to the 29-yr trends in sea ice. Regression, composite, and principal component analyses highlight a seasonality in SH sea ice-atmosphere interactions, whereby Antarctic sea ice variability exhibits the strongest linkages to the SAM and ENSO during the austral cold season months. As noted in previous work, a dipole in SIC anomalies emerges in relation to the SAM, characterized by centers of action located near the Bellingshausen/Weddell and Amundsen/eastern Ross Seas. The structure and magnitude of this SIC dipole is found to vary considerably as a function of season, consistent with the seasonality of the overlying atmospheric circulation anomalies. Relative to the SAM, the pattern of sea ice anomalies linked to ENSO exhibits a similar seasonality but tends to be weaker in amplitude and more diffuse in structure. The relationships between ENSO and sea ice also exhibit a substantial nonlinear component, highlighting the need to consider both season and phase of the ENSO cycle when diagnosing ENSO-SIC linkages. Trends in SIC over 1980-2008 are not significantly related to trends in either the SAM or ENSO during any season, including austral summer when the trend in the SAM is most pronounced.