Observations in patients with metastatic malignancy treated with duazomycin A

Abstract

Duazomycin A a glutamine analogue, chemically similar to DON, was studied in 143 patients. An intravenous dose of 3 mg. per kilogram daily for 14 days appeared to be the tolerated dose in humans. Undesirable effects were nausea, vomiting, diarrhea, stomatitis, leukopenia, and thrombopenia. These effects cleared rapidly when the drug was discontinued. Tumor regression was noted in 6 patients but was evanescent and clinically beneficial to only 2.