Observations in Mice on the Schistosomicidal Properties of 1:7‐BIS(
 p
 ‐Aminophenoxy)Heptane
 in vivo
 and
 in vivo/in vitro

Standen, O. D.

doi:10.1002/9780470719312.ch14

Cited by 8 publications

(7 citation statements)

References 10 publications

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“…In contrast, under in vitro conditions the lack, or diminished effect, of any host immune pressure would allow the whole of the worm's tegumental repair capacity to be directed towards repairing the damaged parts of the tegument. By using, for example, Standen's in vivo/in vitro technique (Standen, 1962) and thereby removing the, initially in wyo-treated, worms from the influence of secondary host-dependent effects, it should be possible to study in more detail the effects of the host immune response on the speed and process of drug-induced, tegumental repair in adult worms.…”

Section: Discussionmentioning

confidence: 99%

Schistosoma mansoni: structural damage and tegumental repair after in vivo treatment with praziquantel

Shaw

Erasmus

1987

Parasitology

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SUMMARYThe long-term, in vivo effects of a single, subcurative dose (200 mg/kg body weight of mouse) of praziquantel on the structure of adult Schistosoma mansoni and on the process and speed of tegumental repair are described. In both male and female worms praziquantel caused often extensive damage to the tegument, in the form of surface blebbings, swellings and lesions, and vacuolization and disruption of the subtegumental tissues. Repair of the drug-induced tegumental damage occurred slowly with partial and, more rarely, complete repair only being seen after 65 days post-treatment (p.t.), although signs of damage were still observed, particularly in male worms, at 100 days p.t. In contrast, repair of damage to the subtegumental/parenchymal tissues including the tegumental perikarya occurred relatively quickly, with the majority of worms examined appearing normal by 8–12 days p.t. The possible role(s) of the host immune response in relation to the speed of tegumental repair in vivo is discussed.

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Section: Discussionmentioning

confidence: 99%

Schistosoma mansoni: structural damage and tegumental repair after in vivo treatment with praziquantel

Shaw

Erasmus

1987

Parasitology

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“…To date, the nature of the metabolic lesion initiating this shift remains uncertain. Previous suggestions that 153C51 and a related secondary amine stressed schistosomes by inhibiting glucose transport (Standen, 1962;Bueding, 1962) have been discounted by recent experiments (Watts, 1978).…”

Section: Introductionmentioning

confidence: 98%

Lysosomes and tegument pathology in the chemotherapy of schistosomiasis with 1,7 -bis(p-aminophenoxy)heptane(153C51)

Watts¹,

Orpin²,

MacCormick³

1979

Parasitology

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SUMMARYOne therapeutic oral dose (400 mg/kg) of 153C51 administered to infested mice caused pathological changes in the dorsal region of the tegument of maleSchistosoma mansoniduring the period 3–24 h after treatment. These changes occurred prior to the ‘hepatic shift’. At the ultrastructural level they consisted of a gradual accumulation in the tegument epidermis of numerous membranous inclusions with the characteristics of residual lysosomes and changes in the localization of acid phosphatase, a lysosomal enzyme. It seemed likely that these changes were due to inhibition or exhaustion of enzyme in the epidermis, followed by re-synthesis of enzyme in the cell bodies and its export to the epidermis. The elimination of hydrolytic activity from lysosomes in the epidermis would explain the accumulation of residual lysosomes. Drug- treated parasites retained their disguise of host red blood cell ghost antigens as shown by indirect fluorescent antibody-labelling and, therefore, it seemed unlikely that immunological factors could be important in producing the tegument pathology.

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“…Another difficulty encountered in the experimental evaluation of schistosomicidal drug activity is interference caused by tissue reactions and immunological responses of the host, which are quite different from one laboratory animal species to the other. As Vogel and Minning (l947), Gonnert (l955c), and Standen (1962Standen ( , 1963 have already pointed out, the parasite is perhaps never killed purely and simply by the action of an antischistosomal drug. It seems, in fact, more likely that the worm is either fixed by connective tissue while still alive or provokes an inflammatory reaction capable of trapping the parasite in the blood vessel.…”

Section: Introductionmentioning

confidence: 99%

“…The events that follow drug treatment in experimental schistosomiasis have been described by several authors (Vogel & Minning, 1947;Kikuth & Gonnert, 1948;Schubert, 1948a, b & c;Standen, 1953Standen, , 1955Standen, , 1962Gonnert, 1955a, b, c & d) for different active compounds, and the responses observed have been evaluated by reference to various criteria. Schubert (1948a) and Standen (1953), for instance, claim that a shifting of worms into the liver is a major characteristic of the response to schistosomicidal drugs.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Niridazole in Experimental Schistosomiasis

Striebel

1969

Annals of the New York Academy of Sciences

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Observations in Mice on the Schistosomicidal Properties of 1:7‐BIS( p ‐Aminophenoxy)Heptane in vivo and in vivo/in vitro

Cited by 8 publications

References 10 publications

Schistosoma mansoni: structural damage and tegumental repair after in vivo treatment with praziquantel

Schistosoma mansoni: structural damage and tegumental repair after in vivo treatment with praziquantel

Lysosomes and tegument pathology in the chemotherapy of schistosomiasis with 1,7 -bis(p-aminophenoxy)heptane(153C51)

The Effects of Niridazole in Experimental Schistosomiasis

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