Observations Concerning the Proteolytic Activity and the Antitryptic Potency of the Blood Serum in Some Dermatoses

Nicolau, S. G.; Bădănoiu, A

doi:10.1159/000254911

Cited by 5 publications

(1 citation statement)

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“…An increase in proteolytic activity in the bullae of pemphigus vulgariS has been observed. 235 Whether this is a fundamental part of the disease is unknown. Significant decrease in proteolytic activity of thyroid tissue from gOiters as compared to normal glands has been demonstrated.…”

Section: Cathepsinsmentioning

confidence: 99%

Proteolytic enzymes in clinical medicine

Colman

1965

Clin Pharma and Therapeutics

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The explosive expansion of our knowledge of the basic properties of the mammalian proteolytic enzymes has stimulated a parallel growth in their applications to clinical medicine. The outcome of this research has been significant advances in the therapy, diagnosis, and pathogenesis of disease processes in almost all fields of medicine. The enzymes discussed in this paper are pepsin, the pancreatic endopeptidases (chymotTypsin, trypsin, kallikrein, and elastase), the blood proteolytic enzymes (thrombin and plasmin), the pancreatic exopeptidases (leucine aminopeptidase and carboxypeptidases), and the tissue proteases (cathepsins). After a brief summary of the physical and biochemical properties of each enzyme, a critical appraisal is made of its potential and limitations as the enzyme is used in clinical medicine. This review concentrates on a delineation of the more important of the recent contributions, a discussion of certain controversial areas, with speCial emphasis on the therapeutic applications and the suggestion of certain fields of investigation which may require more attention in the future.

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Section: Cathepsinsmentioning

confidence: 99%