Observations Concerning the Origin of Renal Lymph

Kaplan, Alex; Friedman, Meyer; Krüger, H

doi:10.1152/ajplegacy.1943.138.3.553

Cited by 22 publications

(10 citation statements)

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“…Our analysis of renal lymph confirms that of Sugarman et al (4) and Kaplan et d ( 5 ) with respect to its urea and sugar content: higher than plasma for urea and lower for sugar. But it differs from that of Sugarman et al in that we found the protein content of lymph to be quite constant at about 3.2 g % (Table 111).…”

supporting

confidence: 91%

“…Its origin is unknown. But we have postulated that it comes from a large interstitial compartment ( 1,3), basing the hypothesis in part on the similarities in composition of "diluting fluid" and renal lymph as reported by Sugarman, Friedman, Barrett and Addis(4) and Kaplan, Friedman and Kruger (5). A more extensive analysis of the composition of the various fluids is reported here: arterial blood, venous blood, renal lymph, urine, and the kidney's distending fluids.…”

mentioning

confidence: 91%

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Relation of Lymph to Distending Fluids of the Kidney.

Swann¹,

Ormsby²,

Delashaw³

et al. 1958

Experimental Biology and Medicine

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supporting

confidence: 91%

mentioning

confidence: 91%

Relation of Lymph to Distending Fluids of the Kidney.

Swann¹,

Ormsby²,

Delashaw³

et al. 1958

Experimental Biology and Medicine

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“…We do not regard the presence of diatrizoate in renal nodes as evidence of leakage of tubular fluid. Intravenous inulin, which resembles diatrizoate in its mode of excretion in man [8] is also found in lymph draining from healthy kidneys and probably derives from renal cortical blood [19,20,23]. The absence of high concentrations of diatrizoate in renal lymph nodes in acute renal failure accords with diminished cortical blood flow [2,17].…”

Section: Discussionmentioning

confidence: 99%

Diatrizoate Levels in the Kidney and Lymph Nodes in Acute Renal Failure in the Rat

McLachlan¹,

Davies²,

Leach³

1974

Nephron

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Acute renal failure was induced in rats by intramuscular injection of glycerol. Concentrations of intravenous 125I-labelled sodium diatrizoate were measured in plasma, renal cortex and medulla, whole kidney and in lymph nodes draining the kidney. Whole kidney concentrations of diatrizoate, which changed little with time, were initially less than 20% of those in control animals. For 30 min after injection, while plasma levels were highest, renal concentrations in acute renal failure were highest in outer cortex. These observations provide further evidence that, though glomerular filtration continues in acute renal failure, it is much reduced. Diatrizoate was observed in renal lymph nodes from control animals and its existence there does not indicate tubular leakage. Smaller amounts were found in lymph nodes in acute renal failure, suggesting insignificant drainage of diatrizoate to renal lymphatics.

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“…One possibility is that the contribution to hilar lymph by tubular reabsorbate, distal to the tip of Henle's loop, is reduced during the decrease in distal reabsorption associated with furosemide. The conclusion that distal reabsorbate normally contributes to hilar lymph is based on the low lymph-plasma concentration ratio that has been found for glucose (8,25) Birtch et al (26), who found a redistribution of renal blood flow during furosemide diuresis. Although the precise relationship between blood flow and lymph production is not clear, a reduced output of lymph could result from a decrease in the medullary circulation of blood.…”

Section: Figurementioning

confidence: 99%

Renal Hilar Lymph

O’Morchoe

O'Morchoe

Heney

1970

Circulation Research

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Renal lymph was collected from single hilar lymphatics in 58 anesthetized dogs (1) to study the mechanism by which lymph production is affected during diuresis and (2) to determine whether a medullary contribution to renal lymph could be defined by changes in the electrolyte concentration of hilar lymph with concomitant alterations in the concentration gradient of the renal medulla. When diuresis was induced by a solute load (mannitol), lymph flow increased by 25 to 300%. On the other hand, when diuresis was induced without such a solute load, lymph flow was either unaffected (mersalyl) or slightly reduced (furosemide). It was concluded that the effect of mannitol on renal lymph flow was mediated primarily through its general eSect on extracellular fluid rather than through any specific intrarenal consequence of the diuresis itself.Control hilar lymph-to-plasma concentration ratios for Na + (1.057 ± 0.040), Ch (1.129 ± 0.040) and Ca 2+ (0.770 ± 0.046) but not K+ (0.986 ± 0.086) were found to be significantly different from 1.0. Failure of mannitol diuresis to alter significantly the lymph-plasma ratios of Na + and Ch~ provided evidence that the high electrolyte concentrations of the inner medulla were not reflected in hilar lymph. The finding that furosemide abolished the lymph-plasma concentration difference for Na + and significantly reduced that for Ch was taken as evidence that the outer medulla was a significant source of renal hilar lymph. Received October 9, 1969. Accepted for publication February 3, 1970. from the decrease in thoracic duct lymph which followed cessation of renal lymph production (1, 2). This method is not, however, suitable for comparison of flow under differing conditions in the same animal, nor does it provide information on changes in the composition of renal lymph. To obtain such information in the present study, renal lymph was collected by cannulating single hilar lymphatics in dogs. ADDITIONALWhile there is evidence that the flow of renal lymph is augmented during the administration of certain diuretics (2-5), the mechanism by which this is brought about has not been studied. Since the infusion of a solute load itself can alter the general level of lymph formation throughout the body, it is apparent that the effect on lymph production by the kidney might not be a specific" consequence of

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Observations Concerning the Origin of Renal Lymph

Cited by 22 publications

References 0 publications

Relation of Lymph to Distending Fluids of the Kidney.

Relation of Lymph to Distending Fluids of the Kidney.

Diatrizoate Levels in the Kidney and Lymph Nodes in Acute Renal Failure in the Rat

Renal Hilar Lymph

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