Observations concerning the microbial etiology of acute salpingitis

Detection of Novel Organisms Associated with Salpingitis, by Use of 16S rDNA Polymerase Chain Reaction

“…Consistent with the finding that abnormal vaginal flora is epidemiologically linked with upper reproductive-tract infection, including salpingitis [7][8][9][10], many bacteria associated with BV were detected by our technique. We detected several BVassociated bacteria by rDNA PCR, including Prevotella spp.…”

“…Although the etiology of salpingitis is often attributed to sexually transmitted organisms (such as C. trachomatis and N. gonorrhoeae) that colonize the cervix and then ascend to the upper genital tract and cause inflammation and tissue damage, the majority of cases have no known etiology [1,[8][9][10]29]. Salpingitis and PID have also been associated with the syndrome of, or organisms associated with, BV [5][6][7][8][9][10], but detecting these and other organisms in the upper genital tract is often difficult when methods of collection are used that might cause contamination of the specimen by vaginal flora.…”

“…Salpingitis and PID have also been associated with the syndrome of, or organisms associated with, BV [5][6][7][8][9][10], but detecting these and other organisms in the upper genital tract is often difficult when methods of collection are used that might cause contamination of the specimen by vaginal flora. Because recent studies using rDNA PCR and sequencing have identified novel, previously uncultured bacterial species in specimens from various human anatomical sites [17,18,[26][27][28], we used this technique to identify organisms in laparoscopically obtained Fallopian-tube specimens from case patients with salpingitis and, for comparison, in similar specimens obtained from control subjects seeking tubal ligations.…”

Vaginal douching among adolescent and young women: more challenges than progress

“…[24][25][26][27] Bacterial vaginosis is the most prevalent form of vaginitis, yet the etiology is unknown. 61,62 BV has been associated with adverse pregnancy outcome, 63-65 endometritis, 9,[66][67][68][69] and complications after invasive gynecologic procedures. An association between BV and risk for HIV-1 infection in young women was found in cross-sectional studies in Uganda and Thailand women.…”

Gynecologic complications of bacterial vaginosis: Fact or fiction?

“…Further evidence supporting this association is offered by Hillier et al [19] showing an association of BV-associated microorganisms, specifically gram-negative anaerobes, with histologic endometritis. The majority of women with laparoscopically proven salpingitis have evidence of an abnormal vaginal ecosystem [20].…”