This paper demonstrates the evaluation of a future aircraft concept equipped with natural laminar flow technology (NLF) based on airline network design and fleet assignment. NLF leads to higher fuel efficiency compared to existing state-of-the-art short-to-medium haul aircraft. The evaluation approach based on network modeling allows to capture network effects such as fleet utilization. Network effects are not captured by a cost benefit analysis applied to standard flight missions. In this study networks are designed for different air transportation scenarios, whereas the flight schedule of an existing European low-cost carrier serves as candidate flight list. Fleet assignment is solved simultaneously by considering a baseline aircraft and the future aircraft concept as candidate fleets. The resulting networks are evaluated with respect to global network profitability, fuel consumption and fleet composition. Results reveal a significant impact of the natural laminar flow performance on fleet deployment and network contribution of the future concept. Further, results indicate turnaround time to be an important driver for fleet deployment caused by network effects.