Observational study of the status of coronary risk biomarkers among Negritos with metabolic syndrome in the east coast of Malaysia

Mokhsin, Atiqah; Mokhtar, Siti Shuhada; Ismail, Aletza Mohd; Nor, Fadzilah Mohd; Shaari, Syahrul Azlin; Nawawi, H.; Yusoff, Khalid; Rahman, Thuhairah Hasrah Abdul; Hoh, Boon Peng

doi:10.1136/bmjopen-2018-021580

Cited by 7 publications

(9 citation statements)

References 49 publications

(43 reference statements)

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“…Our more in-depth study reflected similar findings where Jehai had the lowest prevalence of general obesity but had twice the prevalence of dyslipidaemia and apparent risk for cardiovascular diseases compared to Temiar. However, studies suggest that Negritos, of which Jehai is a subgroup, may present with increased coronary risk and inflammatory biomarkers, yet had low pro-thrombosis and endothelial activation (Mokhtar et al, 2016;Mokhsin et al, 2018). These studies suggested that genetic factors may have resulted in lower HDL levels among Negritos, which was also observed in this current study.…”

Section: Discussionsupporting

confidence: 71%

The Oral, Gut Microbiota and Cardiometabolic Health of Indigenous Orang Asli Communities

Yeo

Lee

Palanisamy

et al. 2022

Front. Cell. Infect. Microbiol.

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The Orang Asli (OA) of Malaysia have been relatively understudied where little is known about their oral and gut microbiomes. As human health is closely intertwined with the human microbiome, this study first assessed the cardiometabolic health in four OA communities ranging from urban, rural to semi-nomadic hunter-gatherers. The urban Temuan suffered from poorer cardiometabolic health while rural OA communities were undergoing epidemiological transition. The oral microbiota of the OA were characterised by sequencing the V4 region of the 16S rRNA gene. The OA oral microbiota were unexpectedly homogenous, with comparably low alpha diversity across all four communities. The rural Jehai and Temiar PP oral microbiota were enriched for uncharacterised bacteria, exhibiting potential for discoveries. This finding also highlights the importance of including under-represented populations in large cohort studies. The Temuan oral microbiota were also elevated in opportunistic pathogens such as Corynebacterium, Prevotella, and Mogibacterium, suggesting possible oral dysbiosis in these urban settlers. The semi-nomadic Jehai gut microbiota had the highest alpha diversity, while urban Temuan exhibited the lowest. Rural OA gut microbiota were distinct from urban-like microbiota and were elevated in bacteria genera such as Prevotella 2, Prevotella 9, Lachnospiraceae ND3007, and Solobacterium. Urban Temuan microbiota were enriched in Odoribacter, Blautia, Parabacetroides, Bacteroides and Ruminococcacecae UCG-013. This study brings to light the current health trend of these indigenous people who have minimal access to healthcare and lays the groundwork for future, in-depth studies in these populations.

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Section: Discussionsupporting

confidence: 71%

The Oral, Gut Microbiota and Cardiometabolic Health of Indigenous Orang Asli Communities

Yeo

Lee

Palanisamy

et al. 2022

Front. Cell. Infect. Microbiol.

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“…[38] Among Negritos, Batek, and Jehai HGs from Peninsular Malaysia who receive significant government support and have stable livelihoods demonstrated a much higher (>40%) prevalence of hypertension than our study population. [39,40] The differences in hypertension prevalence observed across these populations might be due to various variables. Aside from genetic, ethnic, and environmental variations, lifestyle, diet, level of physical activity, behavioral risks, and degree of acculturation should all be considered.…”

Section: Discussionmentioning

confidence: 99%

Arterial hypertension and its covariates among nomadic Raute hunter-gatherers of Western Nepal: a mixed-method study

Koirala

BC²,

Shrestha

et al. 2022

Preprint

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Objectives This study aimed to determine the prevalence of, and understand the factors associated with, hypertension among the Raute nomadic hunter-gatherers of Western Nepal. Design A mixed-method study with quantitative and qualitative analyses. Setting Household survey at Raute temporary camps in the Surkhet District of Karnali Province, Nepal between the period of May to September 2021. Primary and secondary outcome measures The presence of hypertension and its socio-demographic, anthropometric, and behavioral covariates among the participants. Participants For quantitative analysis, all men and non-pregnant women of the nomadic Raute community aged 15 years above were evaluated for hypertension and its covariates. For the qualitative analysis, we purposively selected both Raute and Non-Raute key informants for in-depth interviews to understand, explain and enrich the quantitative findings. Results Of the 85 total eligible participants, 81 [median age 35 years (Interquartile range: 26-51), 46.9% female] were included in the final analysis. The prevalence of hypertension among men, women, and overall was 48.8% (95% confidence interval (CI): 34.4-63.4), 10.5% (95% CI: 3.7-23.1), and 30.9% (95% CI: 21.6-41.5) respectively. Male sex [adjusted Odds Ratio (aOR)=8.05 (95%CI: 2.15-30.11), p=0.002] and increasing age [aOR=1.05 (95% CI: 1.01-1.09), p=0.025] were found significantly associated with hypertension. A large proportion of the participants were current drinkers (91.4%) and tobacco users (70.4%), yet neither of these factors had a significant association with hypertension. Effect of socio-economic transition; changing patterns of alcohol and tobacco use, changing diet and food security; and traditional health care practices were the themes identified in the qualitative analysis. Conclusion This study found a high prevalence of hypertension, alcohol, and tobacco use among Raute nomadic hunter-gatherers facing socio-economic and nutritional transition. Further longitudinal studies and effective culture-centered community-based interventions are urgently needed to reduce the morbidity and mortality associated with hypertension in this endangered indigenous population. Keywords Hunter-gatherers, Foragers, Hypertension, Blood pressure, Socio-economic transition, Raute

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“…Both purposive and snowball sampling approaches are non-random sampling methods that may have limitations but generally used in Orang Asli research. 8,29 The present study provides a community-based picture of the KAP on lifestyle-related NCDs among Orang Asli people in Jelebu, Negeri Sembilan. Poverty and underdevelopment are the predominant features of Orang Asli communities, and education levels still lagging compared to other communities.…”

Section: Correlation Between Knowledge Attitude and Practices Regarding Lifestyle-related Ncdsmentioning

confidence: 94%

Knowledge, Attitude and Practices Towards Lifestyle Related Non-Communicable Diseases (NCDs): A Cross Sectional Study among Indigenous Orang Asli Adults in Negeri Sembilan, Malaysia

Ithnin¹,

Naum²,

Juliana³

et al. 2020

imjm

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INTRODUCTION: An increase in the prevalence of non-communicable diseases (NCDs) among Orang Asli in Malaysia was reported to be associated with their lifestyle changes. This study aimed to determine the level of knowledge, attitude, and practice (KAP) on NCDs among the Orang Asli community and its association with demographic factors of gender, age, and education level. MATERIAL AND METHODS: A cross-sectional study among consented adult Orang Asli in Jelebu, Negeri Sembilan, was conducted by a face-to-face interview using a validated questionnaire. Their knowledge, attitude, and practice on selected NCD risk factors, complications, and treatment was recorded. Bivariate analysis was performed to test the association between their demographic profile and KAP score. RESULTS: A total of 325 respondents with a mean age of 39.9 (±13.2) ranged from 18 to 83 years old participated in this study. Majority of the participants (72.3%) had inadequate knowledge. Despite the inadequacy, they have a good attitude (72.3%) and a moderate practice level (63.4%). Respondents with higher education backgrounds had significantly better knowledge scores compared to lower education background (p<0.001). Female respondents had better practice scores than male respondents (p=0.001). CONCLUSIONS: The study shows that the level of knowledge on NCDs among Orang Asli is low with a moderately healthy lifestyle. Improving the Orang Asli understanding of NCDs prevention by incorporating health programs regularly in their community is a strategic method to increase their awareness. Hence, escalating their good practice on NCDs and eventually their health.

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Observational study of the status of coronary risk biomarkers among Negritos with metabolic syndrome in the east coast of Malaysia

Cited by 7 publications

References 49 publications

The Oral, Gut Microbiota and Cardiometabolic Health of Indigenous Orang Asli Communities

The Oral, Gut Microbiota and Cardiometabolic Health of Indigenous Orang Asli Communities

Arterial hypertension and its covariates among nomadic Raute hunter-gatherers of Western Nepal: a mixed-method study

Knowledge, Attitude and Practices Towards Lifestyle Related Non-Communicable Diseases (NCDs): A Cross Sectional Study among Indigenous Orang Asli Adults in Negeri Sembilan, Malaysia

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