Observational study of sleep, respiratory mechanics and quality of life in patients with non-cystic fibrosis bronchiectasis: a protocol study: Figure 1

Júnior, Newton Santos Faria; Oliveira, Luís Vicente Franco de; Perez, Eduardo Araújo; Oliveira, Ezequiel Fernandes; Apostólico, Nádua; Pereira, Nixon Alves; Santos, Israel Reis; Urbano, Jéssica Julioti; Souza, Isabela Max Crema; Polonio, Igor Bastos; Romaldini, João Hamilton; Pereira, Déborah Madeu; Alves, Vera Lúcia dos Santos; Souza, Ângela Honda; Nascimento, Oliver Augusto; Jardim, José Roberto; Stirbulov, Roberto

doi:10.1136/bmjopen-2015-008183

Cited by 4 publications

(2 citation statements)

References 30 publications

(28 reference statements)

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“…The patients were recruited from two BCTS Outpatient Clinics in Sao Paulo, Brazil, between April 2013 and March 2016. The study protocol is being published elsewhere [ 34 ].…”

Section: Methodsmentioning

confidence: 99%

Evaluation of obstructive sleep apnea in non-cystic fibrosis bronchiectasis: A cross-sectional study

et al. 2017

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The relationship between sleep disorders and bronchiectasis has not been well described. We hypothesize that, due to the irreversible dilatation of the bronchi, the presence of secretions, and airflow obstruction, patients with non-cystic fibrosis bronchiectasis may be predisposed to hypoxemia during sleep, or to symptoms that may lead to arousal. A cross-sectional observational study was performed involving 49 patients with a clinical diagnosis of non-cystic fibrosis bronchiectasis (NCFB). All patients underwent clinical evaluation, spirometry, and polysomnography, and were evaluated for the presence of excessive daytime sleepiness (EDS) and risk of obstructive sleep apnea (OSA). The mean age of the participants was 50.3 ± 13.6 years; 51.1% of patients were male and had a mean body mass index of 23.8 ± 3.4 kg/m2. The mean total sleep time (TST) was 325.15 ± 64.22 min with a slight reduction in sleep efficiency (84.01 ± 29.2%). Regarding sleep stages, stage 1 sleep and REM sleep were abnormal. OSA was present in 40.82% of the patients. The mean arousal index was 5.6 ± 2.9/h and snoring was observed in 71.43% of the patients. The oxygen desaturation index (ODI) was 14.35 ± 15.36/h, mean minimum oxygen saturation (SpO2 nadir) was 83.29 ± 7.99%, and mean TST with an SpO2 less than 90% was 30.21 ± 60.48 min. EDS was exhibited by 53.06% of the patients and 55.1% were at high risk of developing OSA. The patients infected by Pseudomonas aeruginosa had higher apnea-hypopnea indices, ODI, and TST with SpO2 < 90%, and lower values of SpO2 nadir. Adult patients with clinically stable NCFB, especially those infected by Pseudomonas aeruginosa, display EDS and a high prevalence of OSA, associated with considerable oxygen desaturation during sleep.

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“…The patients were recruited from two BCTS Outpatient Clinics in Sao Paulo, Brazil, between April 2013 and March 2016. The study protocol is being published elsewhere [ 34 ].…”

Section: Methodsmentioning

confidence: 99%

Evaluation of obstructive sleep apnea in non-cystic fibrosis bronchiectasis: A cross-sectional study

et al. 2017

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“…It has been shown that patients with bronchiectasis have multiple risk factors for SDB, such as chronic inflammation and ventilatory impairment due to obstructive and/or restrictive patterns and chronic secretions, caused by impaired muco-ciliary clearance and by excessive production of mucous plugs [ 56 , 57 ]. Only a few studies have thoroughly investigated the prevalence of SDB, particularly OSA, in patients with bronchiectasis [ 10 , 11 ].…”

Section: Sleep-disordered Breathing and Bronchiectasismentioning

confidence: 99%

Sleep-Disordered Breathing and Chronic Respiratory Infections: A Narrative Review in Adult and Pediatric Population

Faverio

Zanini

Monzani

et al. 2023

IJMS

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Sleep-disordered breathing (SDB) comprises different diseases characterized by abnormal respiratory patterns during sleep including obstructive sleep apnea. SDB prevalence and impact in patients with chronic respiratory infections have been only marginally studied. The purpose of this narrative review is to report the prevalence and impact of SDB in chronic respiratory infections, including cystic fibrosis (CF), bronchiectasis and mycobacterial infections, and explore the possible pathophysiological mechanisms. Common pathophysiological mechanisms, underlying SDB onset in all chronic respiratory infections, include inflammation, which plays a central role, chronic nocturnal cough and pain, excessive production of mucous plugs, presence of obstructive and/or restrictive ventilatory impairment, upper airways involvement, and comorbidities, such as alteration of nutritional status. SDB may affect about 50% of patients with bronchiectasis. The severity of the disease, e.g., patients colonized with P. aeruginosa and frequent exacerbators, as well as comorbidities, such as chronic obstructive pulmonary disease and primary ciliary dyskinesia, may impact SDB onset. SDB may also frequently complicate the clinical course of both children and adults with CF, impacting the quality of life and disease prognosis, suggesting that their routine assessment should be incorporated into the clinical evaluation of patients from the first stages of the disease regardless of suggestive symptoms, in order to avoid late diagnosis. Finally, although the prevalence of SDB in patients with mycobacterial infections is uncertain, extrapulmonary manifestations, particularly nasopharyngeal locations, and concomitant symptoms, such as body pain and depression, may act as atypical predisposing factors for their development.

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Effects of Obstructive Sleep Apnea on Airway Immunity and Susceptibility to Respiratory Infections

Epstein,

Jun,

Deng

et al. 2024

Sleep Medicine Clinics

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Observational study of sleep, respiratory mechanics and quality of life in patients with non-cystic fibrosis bronchiectasis: a protocol study: Figure 1

Cited by 4 publications

References 30 publications

Evaluation of obstructive sleep apnea in non-cystic fibrosis bronchiectasis: A cross-sectional study

Evaluation of obstructive sleep apnea in non-cystic fibrosis bronchiectasis: A cross-sectional study

Sleep-Disordered Breathing and Chronic Respiratory Infections: A Narrative Review in Adult and Pediatric Population

Effects of Obstructive Sleep Apnea on Airway Immunity and Susceptibility to Respiratory Infections

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