Observational study of clinical characteristics of dome-shaped macula in Chinese Han with high myopia at Zhongshan Ophthalmic Centre

Zhao, Xiujuan; Ding, Xiaoyan; Lyu, Cancan; Li, Shiyi; Yu, Lunyin; Chen, Xiaohong; Tanumiharjo, Silvia; Zhang, Aiyuan; Lu, Jinge; Liang, Xiaoling; Jin, Chenjin; Lü, Lin

doi:10.1136/bmjopen-2018-021887

Cited by 36 publications

(36 citation statements)

References 18 publications

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“…Moreover, miR‐21 levels in the lung correlated with COPD severity and its regulation could be a treatment for the early stage of disease (Yang et al, ). In addition, CSE increased the miR‐21 expression and autophagy in 16HBE cells (Zhao et al, ).…”

Section: Discussionmentioning

confidence: 99%

MiR‐21 upregulation increases IL‐8 expression and tumorigenesis program in airway epithelial cells exposed to cigarette smoke

Pace

Vincenzo

Salvo

et al. 2019

Journal Cellular Physiology

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Background: Cigarette smoke exposure, increasing Toll-like receptor 4 (TLR4) and reactive oxygen species (ROS), promotes inflammatory responses in airway epithelial cells. Chronic inflammation, microRNA (miRNA), and oxidative stress are associated with cancer development.Aims: The present study was aimed to explore whether cigarette smoke exposure, altering miR-21 expression, promoted inflammatory responses and tumorigenesis processes in airway epithelial cells.Methods: Airway normal and cancer epithelial cells (16HBE and A549) were exposed to cigarette smoke extracts (CSE) or with/without agomiR-21, and then it was assessed: a) miR-21 expression; b) signal transducer and activator of transcription 3 (STAT3) nuclear protein expression and ERK1/2 activation; c) IL-8 gene expression and protein release. An antagonist of TLR4 (CLI-095) and the antioxidant flavonoid, apigenin, were also included to evaluate miR-21 expression in CSE exposed cells. Results: It was demonstrated that: a) A549 cells constitutively expressed higher levels of miR-21 and IL-8; b) CSE increased STAT3 nuclear expression in 16HBE; c) in both cell lines, CSE and agomiR-21 increased: miR-21 expression; ERK1/2 activation and IL-8 gene expression and protein release; d) TLR4 inhibition counteracted the effects of CSE on miR-21 in A549; e) apigenin reduced miR-21 and IL-8 gene expression in both cell lines. Conclusions: Data herein provided identified for the first time new mechanisms supporting the crucial role of cigarette smoke-induced miR-21 expression in the amplification of inflammatory responses and in tumorigenesis processes within the airways. K E Y W O R D S bronchial epithelial cells, cigarette smoke, miRNA, oxidative stress

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Section: Discussionmentioning

confidence: 99%

MiR‐21 upregulation increases IL‐8 expression and tumorigenesis program in airway epithelial cells exposed to cigarette smoke

Pace

Vincenzo

Salvo

et al. 2019

Journal Cellular Physiology

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“…53 The BCVA ranged from 6/15 to 6/24. 53,113,114 Management of dome-shaped macula is not well defined and ranges from close observation to photodynamic therapy, focal laser photocoagulation, and spironolactone, depending on the extent of the condition and co-existing pathologies. 94…”

Section: Posterior Staphylomamentioning

confidence: 99%

Posterior segment conditions associated with myopia and high myopia

Jagadeesh

Philip

Fedtke

et al. 2020

Clinical and Experimental Optometry

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Myopia, and especially high myopia, is associated with a number of posterior segment changes that are considered to be mostly a consequence of the increased axial elongation. This can result in mechanical strain, attendant vascular changes, stretching and thinning of tissues, and atrophy/deformation of tissues in later or more advanced stages. Such myopiarelated changes are observed as changes and/or abnormalities in the vitreous, choroid, retina and peripheral retina, sclera and/or optic disc. Although many of these changes are benign, at times they may be associated with significant vision impairment that either requires active intervention or may suggest future progression of the disease. This review systematically addresses the posterior segment conditions seen in myopic eyes, describes the features associated with the condition and details management pathways.

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“…1,4 Similarly, the clinical features of DSM varied in different population. [3][4][5][6] Close associations have been reported between DSM and many maculopathies, including myopic retinoschisis (MRS). 3,7 MRS is one of the main complications leading to visual loss in highly myopic eyes, appeared as splitting or formation of an intraretinal cyst separating the retina with intraretinal columns in OCT.…”

mentioning

confidence: 99%

The Morphological Relationship Between Dome-Shaped Macula and Myopic Retinoschisis: A Cross-sectional Study of 409 Highly Myopic Eyes

Dong

Zhang

Wei

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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Citation: Fang D, Zhang Z, Wei Y, et al. The morphological relationship between dome-shaped macula and myopic retinoschisis: a cross-sectional study of 409 highly myopic eyes. Invest Ophthalmol Vis Sci. 2020;61(3):19. https://doi.org/10.1167/iovs.61.3.19 PURPOSE.The purpose of this study was to analyze the clinical features of dome-shaped macula (DSM) in highly myopic eyes and its morphological relationship with myopic retinoschisis (MRS). METHODS.In this cross-sectional study, 409 eyes of 409 patients with high myopia who had spectral-domain optical coherence tomography (OCT) examinations were included. The associations of DSM with the distribution of MRS and ocular biometry were evaluated. RESULTS.Of 409 eyes, DSM was detected in 64 eyes (15.6%). The eyes with DSM were more myopic (−18.8 ± 3.9 vs. −13.4 ± 5.9; P < 0.001) and had longer axial length (31.7 ± 2.4 vs. 29.5 ± 2.5; P < 0.001) compared with those without DSM. A higher rate of extrafoveal retinoschisis (35.9% vs. 9.6%; P < 0.001) and a lower rate of foveoschisis (10.9% vs. 26.1%; P = 0.01) were detected in the eyes with DSM compared with those without DSM. In the eyes with DSM, MRS was detected in 30 eyes (46.9%). MRS predominantly affected the extrafoveal area (76.7%), especially the base of the dome (82.6%). The extrafoveal retinoschisis was most frequently distributed in the superior quadrant (52.2%). None of the eyes with DSM displayed fovea-only retinoschisis. The ratio of the height and width of the macular bulge was higher in eyes with MRS than those without MRS (0.05 vs. 0.04; P = 0.001). CONCLUSIONS.A DSM is found in highly myopic eyes with a longer axial length. MRS in eyes with DSM is more likely to affect the extrafoveal area, especially the base of the dome. A steeper macular bulge is associated with the occurrence of MRS.

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Observational study of clinical characteristics of dome-shaped macula in Chinese Han with high myopia at Zhongshan Ophthalmic Centre

Cited by 36 publications

References 18 publications

MiR‐21 upregulation increases IL‐8 expression and tumorigenesis program in airway epithelial cells exposed to cigarette smoke

MiR‐21 upregulation increases IL‐8 expression and tumorigenesis program in airway epithelial cells exposed to cigarette smoke

Posterior segment conditions associated with myopia and high myopia

The Morphological Relationship Between Dome-Shaped Macula and Myopic Retinoschisis: A Cross-sectional Study of 409 Highly Myopic Eyes

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