Observational retrospective study evaluating the effects of oral isotretinoin in keloids and hypertrophic scars

Abstract

These findings may indicate that the occurrence of hypertrophic scars or keloids in patients using oral isotretinoin is an undesirable event arising from an individual response and may be related to inflammatory acne evolution.

The Keloid Disorder: Heterogeneity, Histopathology, Mechanisms and Models

“…Additionally, inflammatory skin conditions such as acne, (peri)folliculitis, chicken pox, herpes zoster and hidradenitis suppurativa, may also lead to the development of keloids (Nemeth, 1993;Murray, 1994;English and Shenefelt, 1999;Bran et al, 2009). Isotretinoin is often used to treat acne and has been suggested to act as an additional predisposing factor, though this has not yet been proven conclusively (Guadanhim et al, 2016). While burns have often been mentioned as one of the many potential keloid-inducing events (Trusler and Bauer, 1948;Nemeth, 1993;Murray, 1994;English and Shenefelt, 1999;Bran et al, 2009), they are usually associated with the formation of widespread hypertrophic scars (Middelkoop et al, 2011;Gold et al, 2014) rather than keloids.…”

Aspectos Epidemiológicos Da Leishmaniose Visceral No Estado Do Piauí No Período De 2015 a 2018

“…O uso do laser ablativo fracionado para cicatrizes de acne na face é seguro, mesmo durante o uso da isotretinoína oral, inclusive há relatos de melhores resultados (Khatri,2015McDonald, 2017Spring, 2017;Waldman, 2017). Teste de dermabrasão numa pequena área da face com cicatrizes atróficas, realizado durante o tratamento e quimiodermabrasão realizada entre um e três meses após o tratamento, não desencadearam anormalidades na cicatrização no seguimento de seis meses (Bagatin, 2010;Picosse, 2012;Guadanhim, 2016). A associação da isotretinoína oral à depressão, ideação suicida e suicídio causou muita discussão e controvérsia.…”

Acne Vulgaris: A Patient and Physician’s Experience

“…Earlier experiences with isotretinoin raised concerns regarding wound healing and the development of keloids in individuals who had procedures while on isotretinoin or after discontinuation of the drug [40]. However, more recent reviews suggest that -with the exception of ablative laser resurfacing and dermabrasion -cosmetic procedures or skin surgery or wisdom teeth extraction do not need to be avoided during or immediately after treatment with isotretinoin [41][42][43][44]. Yet, delay of these elective procedures for 6-12 months after completion of isotretinoin therapy -if possible -should be considered [1].…”