Observational multi-centre, prospective study to characterize novel pathogen-and host-related factors in hospitalized patients with lower respiratory tract infections and/or sepsis - the “TAILORED-Treatment” study

Houten, Chantal B. van; Oved, Kfir; Eden, Eran; Golan‐Cohen, Avivit; Engelhard, Dan; Boers, Stefan A.; Kraaij, Robert; Karlsson, Roger; Fernández, David Fernández; González, Eva; Li, Yunlei; Stubbs, Andrew; Moore, Edward R. B.; Hays, John P.; Bont, Louis

doi:10.1186/s12879-018-3300-9

Cited by 17 publications

(21 citation statements)

References 35 publications

(34 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, we followed the UK's National Health Service standard for evaluating diagnostic tests and employed an expert panel reference standard [17]. As described previously, we established expert panels with experienced paediatricians for the paediatric cohort and specialists in internal medicine, pulmonology and infectious diseases for the adult cohort [13]. Every recruited patient was diagnosed by three panel members, and each expert assigned one of the following classifications to each patient: viral infection; bacterial infection; mixed infection (i.e.…”

Section: Discussionmentioning

confidence: 99%

“…Patient recruitment for this prospective biomarker TTT-study took place in convenience and consecutive series at the ED and wards of secondary and tertiary hospitals in The Netherlands and Israel [13]. For this subgroup analyses, paediatric patients (aged ≥ 1 month) and adult patients (aged > 18 years), with a suspected upper and/or lower RTI and a maximal disease duration of 8 days, were selected.…”

Section: Methodsmentioning

confidence: 99%

Section: Data Collectionmentioning

confidence: 99%

“…Data collection of this TTT-study was described previously [13]. In short, all available clinical data (including biomarkers tested for routine care, a study specific nasal swab and information from a 28-day follow-up assessment) was recorded in an electronic Case Report Form (eCRF) [13]. A multiplex PCR-based assay of the 14 most common respiratory pathogens (nine viruses, five bacteria) was performed on all nasal swabs (MagnaPure LC total nucleic acid kit and MagnaPure 96 DNA, Roche Diagnostics, Mannheim, Germany) [15].…”

Section: Data Collectionmentioning

confidence: 99%

“…Therefore, there are increasing efforts to study host-biomarkers that could discriminate bacterial from non-bacterial infections [12]. A prospective, international study (The "TAILORED Treatment" (TTT) study) was designed to generate a multi-parametric model for distinguishing between bacterial and viral infections based on new host-or pathogen-related biomarkers [13]. As a gold standard to diagnose bacterial infections is missing, this study used an expert panel reference standard to diagnose each individual patient.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Antibiotic misuse in respiratory tract infections in children and adults—a prospective, multicentre study (TAILORED Treatment)

Houten

Golan‐Cohen

Engelhard

et al. 2019

Eur J Clin Microbiol Infect Dis

View full text Add to dashboard Cite

Respiratory tract infections (RTI) are more commonly caused by viral pathogens in children than in adults. Surprisingly, little is known about antibiotic use in children as compared to adults with RTI. This prospective study aimed to determine antibiotic misuse in children and adults with RTI, using an expert panel reference standard, in order to prioritise the target age population for antibiotic stewardship interventions. We recruited children and adults who presented at the emergency department or were hospitalised with clinical presentation of RTI in The Netherlands and Israel. A panel of three experienced physicians adjudicated a reference standard diagnosis (i.e. bacterial or viral infection) for all the patients using all available clinical and laboratory information, including a 28-day follow-up assessment. The cohort included 284 children and 232 adults with RTI (median age, 1.3 years and 64.5 years, respectively). The proportion of viral infections was larger in children than in adults (209(74%) versus 89(38%), p < 0.001). In case of viral RTI, antibiotics were prescribed (i.e. overuse) less frequently in children than in adults (77/209 (37%) versus 74/89 (83%), p < 0.001). One (1%) child and three (2%) adults with bacterial infection were not treated with antibiotics (i.e. underuse); all were mild cases. This international, prospective study confirms major antibiotic overuse in patients with RTI. Viral infection is more common in children, but antibiotic overuse is more frequent in adults with viral RTI. Together, these findings support the need for effective interventions to decrease antibiotic overuse in RTI patients of all ages. Electronic supplementary material The online version of this article (10.1007/s10096-018-03454-2) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Data Collectionmentioning

confidence: 99%

Section: Data Collectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Antibiotic misuse in respiratory tract infections in children and adults—a prospective, multicentre study (TAILORED Treatment)

Houten

Golan‐Cohen

Engelhard

et al. 2019

Eur J Clin Microbiol Infect Dis

View full text Add to dashboard Cite

show abstract

Respiratory syncytial virus incidence and typing in the last six seasons in the north of Spain (Asturias). Genetic characterization during the SARS‐CoV‐2 pandemic

Rojo‐Alba,

Martínez,

González‐Alba

et al. 2024

Journal of Medical Virology

View full text Add to dashboard Cite

Respiratory syncytial virus is associated with lower respiratory tract infections. As several types and genotypes can circulate at the same time, genomic characterization is important for timely epidemiological control and treatment measures. In the last 6 seasons (2017–2023), 191 236 nasopharyngeal swabs were processed for respiratory viruses to determine the etiology of acute respiratory infections, describe the incidence and distribution of RSV types and enrich the data of epidemiological molecular studies on RSV in Spain. The incidence of RSV reached 7% in the pre‐pandemic season. RSV was most frequent in children under 5 years of age (12.6%), but was also significant in those over 70 years of age (5.63%). The measures taken to control SARS‐CoV‐2 infection were useful for RSV control and the incidence decreased to 1.8%, but caused a change in the types. Pre‐pandemic, the majority circulating types were RSV‐B/RSV‐B/RSV‐A and in the pandemic it was RSV‐B/RSV‐B. In the last season, RSV‐B and RSV‐A were detected in the same proportion. Genetic characterization showed three new clades. This has been taken into account to understand the epidemiology as well as the development of therapeutic and preventive strategies.

show abstract

Introduction to the database “efficacy of different treatment modalities for lower respiratory tract infections in children”

Deng,

Hu,

Zou

et al. 2024

Pediatric Discovery

View full text Add to dashboard Cite

This study aimed to establish a registry database of different treatment modalities for lower respiratory tract infections (LRTIs) in Chinese children, thereby filling gaps in knowledge on clinical characteristics, treatment modalities, and rational drug use in relation to LRTIs in Chinese children, and providing large amounts of continuous, complete, scientific, and objective clinical data, and an information exchange platform. Multicenter data from these children's clinical visits were collected, pooled, and analyzed using medical informatics and statistical techniques to explore their potential value. The database was preliminarily established and a real‐world study cohort was constructed based on a total of 4805 patients registered in this database. Pneumonia was identified as the most common type of LRTIs (72.44%), followed by acute bronchitis (20.71%). The mean age of the enrolled children with LRTIs was 3.26 ± 2.84 years, and boys accounted for 59.21% of the samples. Among the enrolled children, pneumonia and acute bronchitis had the highest incidence in children aged 1–3 years (27.44%) and those aged 3–6 years (34.16%), respectively. In this national, multicenter, observational database of LRTIs in children, the real‐world characteristics and treatment modalities for LRTIs in Chinese children are elucidated. This database will help improve the research efficiency of clinicians and facilitate the exploration of underlying clinical patterns in real‐world medical big data.

show abstract

Observational multi-centre, prospective study to characterize novel pathogen-and host-related factors in hospitalized patients with lower respiratory tract infections and/or sepsis - the “TAILORED-Treatment” study

Cited by 17 publications

References 35 publications

Antibiotic misuse in respiratory tract infections in children and adults—a prospective, multicentre study (TAILORED Treatment)

Antibiotic misuse in respiratory tract infections in children and adults—a prospective, multicentre study (TAILORED Treatment)

Respiratory syncytial virus incidence and typing in the last six seasons in the north of Spain (Asturias). Genetic characterization during the SARS‐CoV‐2 pandemic

Introduction to the database “efficacy of different treatment modalities for lower respiratory tract infections in children”

Contact Info

Product

Resources

About