Observational Dutch Young Symptomatic StrokE studY (ODYSSEY): study rationale and protocol of a multicentre prospective cohort study

Arntz, Renate M.; Alebeek, Mayte E van; Synhaeve, Nathalie E.; Brouwers, P. J. A. M.; Dijk, Gert W van; Gons, Rob A.R.; Heijer, Tom den; Kort, Paul L.M. de; Laat, Karlijn F. de; Norden, Anouk Gw van; Vermeer, Sarah E.; Vlugt, Maureen J. van der; Kessels, Roy P. C.; Dijk, Ewoud J. van; Leeuw, Frank‐Erik de

doi:10.1186/1471-2377-14-55

Cited by 16 publications

(14 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To what extent cognitive recovery continues beyond this time period will need further studies. In this regard, important insights are expected from the ongoing Observational Dutch Young Symptomatic Stroke Study (ODYSSEY), which aims to include 1500 patients and will be assessing cognitive function 6 weeks and 1 year after the index event . A recent study suggests that most cognitive recovery happens within the first 6 months, with little change thereafter , highlighting the importance of exploring the dynamic course of post‐stroke cognitive impairment especially early on.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and short‐term changes of cognitive dysfunction in young ischaemic stroke patients

Pinter

Enzinger

Gattringer

et al. 2019

Euro J of Neurology

View full text Add to dashboard Cite

Background and purpose Information on the prevalence and course of post‐stroke cognitive impairment in young stroke patients is limited. The aim was to assess a consecutive sample of acute young ischaemic stroke patients (18–55 years) for the presence and development of neuropsychological deficits. Methods Patients prospectively underwent a comprehensive clinical and cognitive assessment, examining general cognitive function, processing speed, attention, flexibility/executive function and word fluency within the first 3 weeks after hospital admission (median assessment at day 6) and at a 3 months’ follow‐up (FU). Cognitive dysfunction was defined in comparison to age‐standardized published norms. Results At baseline (N = 114), deficits were highly prevalent in processing speed (56.0%), flexibility/executive function (49.5%), attention (46.4%) and general cognitive function (42.1%). These frequencies were comparable for those with FU assessment (N = 87). In most domains, cognitive performance improved within 3 months, except for word fluency. However, in about one‐third of patients, cognitive deficits (as defined by 1.5 standard deviations below the standardized mean) were still present 3 months after stroke. At FU, 44.0% were impaired in the domain flexibility/executive function, 35.0% in processing speed and 30.0% in attention. Conclusions The high prevalence of cognitive deficits in acute young patients with ischaemic stroke highlights the importance of early post‐stroke cognitive assessment to capture a patient's dysfunction in a comprehensive manner and to offer adequate rehabilitation. The role of factors which promote neuropsychological deficits needs further exploration.

show abstract

Section: Discussionmentioning

confidence: 99%

Prevalence and short‐term changes of cognitive dysfunction in young ischaemic stroke patients

Pinter

Enzinger

Gattringer

et al. 2019

Euro J of Neurology

View full text Add to dashboard Cite

show abstract

“…Details of the study have been described previously. 10 For this study, we included patients with ischemic stroke. Patients were included consecutively between May 2013 until end of inclusion in February 2021.…”

Section: Methodsmentioning

confidence: 99%

Risk Factors and Causes of Ischemic Stroke in 1322 Young Adults

Ekker

Verhoeven

Schellekens

et al. 2023

Stroke

Self Cite

View full text Add to dashboard Cite

BACKGROUND: Identification of risk factors and causes of stroke is key to optimize treatment and prevent recurrence. Up to one-third of young patients with stroke have a cryptogenic stroke according to current classification systems (Trial of ORG 10172 in Acute Stroke Treatment [TOAST] and atherosclerosis, small vessel disease, cardiac pathology, other causes, dissection [ASCOD]). The aim was to identify risk factors and leads for (new) causes of cryptogenic ischemic stroke in young adults, using the pediatric classification system from the IPSS study (International Pediatric Stroke Study). METHODS: This is a multicenter prospective cohort study conducted in 17 hospitals in the Netherlands, consisting of 1322 patients aged 18 to 49 years with first-ever, imaging confirmed, ischemic stroke between 2013 and 2021. The main outcome was distribution of risk factors according to IPSS classification in patients with cryptogenic and noncryptogenic stroke according to the TOAST and ASCOD classification. RESULTS: The median age was 44.2 years, and 697 (52.7%) were men. Of these 1322 patients, 333 (25.2%) had a cryptogenic stroke according to the TOAST classification. Additional classification using the ASCOD criteria reduced the number patients with cryptogenic stroke from 333 to 260 (19.7%). When risk factors according to the IPSS were taken into account, the number of patients with no potential cause or risk factor for stroke reduced to 10 (0.8%). CONCLUSIONS: Among young adults aged 18 to 49 years with a cryptogenic ischemic stroke according to the TOAST classification, risk factors for stroke are highly prevalent. Using a pediatric classification system provides new leads for the possible causes in cryptogenic stroke, and could potentially lead to more tailored treatment for young individuals with stroke.

show abstract

“…Yet, some studies have shown that the prevalence of stroke is increasing among younger adults. 11-12 Investigation of the health and economic burden of stroke among those younger than 65 years is needed to guide public health interventions.…”

Section: Introductionmentioning

confidence: 99%

Hospital Costs Associated With Atrial Fibrillation for Patients With Ischemic Stroke Aged 18–64 Years in the United States

Wang

Joo

Tong

et al. 2015

Stroke

View full text Add to dashboard Cite

Background and purpose Hospital costs associated with atrial fibrillation (AFib) among stroke patients have not been well-studied, especially among people younger than 65 years. We estimated the AFib-associated hospital costs in U.S. patients aged 18-64 years. Methods We identified hospital admissions with a primary diagnosis of ischemic stroke from the 2010-2012 MarketScan Commercial Claims and Encounters inpatient datasets, excluding those with capitated health insurance plans, aged <18 or >64, missing geographic region, hospital costs below the 1st or above 99th percentile, and having carotid intervention (N=40,082). We searched the data for AFib and analyzed the costs for non-repeat and repeat stroke admissions separately. We estimated the AFib-associated costs using multivariate regression models controlling for age, sex, geographic region, and Charlson comorbidity index. Results Of the 33,500 non-repeat stroke admissions, 2,407 (7.2%) had AFib. Admissions with AFib cost $4,991 more than those without AFib ($23,770 vs. $18,779). For the 6,582 repeat stroke admissions, 397 (6.0%) had AFib. The costs were $3,260 more for those with AFib than those without ($24,119 vs. $20,929). After controlling for potential confounders, AFib-associated costs for non-repeat stroke admissions were $4,905, representing 20.6% of the total costs for the admissions. Both the hospital costs and the AFib-associated costs were associated with age, but not sex. AFib-associated costs for repeat stroke admissions were not significantly higher than for non-AFib patients, except for those aged 55-64 ($3,537). Conclusions AFib increased the hospital cost of ischemic stroke substantially. Further investigation on AFib-associated costs for repeat stroke admissions is needed.

show abstract

Observational Dutch Young Symptomatic StrokE studY (ODYSSEY): study rationale and protocol of a multicentre prospective cohort study

Cited by 16 publications

References 56 publications

Prevalence and short‐term changes of cognitive dysfunction in young ischaemic stroke patients

Prevalence and short‐term changes of cognitive dysfunction in young ischaemic stroke patients

Risk Factors and Causes of Ischemic Stroke in 1322 Young Adults

Hospital Costs Associated With Atrial Fibrillation for Patients With Ischemic Stroke Aged 18–64 Years in the United States

Contact Info

Product

Resources

About