Observation on the Effect of Bone Grafting Alone and Guided Tissue Regeneration Combined with Bone Grafting to Repair Periodontal Intraosseous Defects

Yuan, Yongping; Zhao, Jiajia; He, Nv

doi:10.1155/2021/1743677

Cited by 5 publications

(1 citation statement)

References 25 publications

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“…PRF enhances wound healing and regeneration and several studies show rapid and accelerated woundhealing with the use of PRF than without it [5] It showed that the GTR combined with bone grafting was better than bone grafting alone in improving the aesthetics of the patients' gums, which might be related to its promotion of soft tissue healing and the good integration of soft tissues [6].…”

Section: Introductionmentioning

confidence: 99%

Oral–surgical Treatment of Periodontal Pocket With Guided Bone and Soft Tissue Regeneration

Evrosimovska

Janeva²,

Janeva³

et al. 2022

JMS

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Periodontal disease is defined as a complex, multifactorial disease characterized by the loss of connective tissue attachment with destruction of periodontal tissues. The aim of periodontal therapy is to eliminate inflammatory process, prevent the progression of periodontal disease and also to regenerate the lost of periodontal tissues.Loss of the bone support by creating a periodontal pocket is one of the most common cause of tooth extraction. Their treatment can be conservative and surgical.The purpose of this paper is to demonstrate the treatment of infrabony periodontal defects with bone and soft tissue regeneration.On periodontal examination and radiographic evaluation, the female 56-year-old patient presented with an infrabony defect extending up to apical third of the mesial side of the right maxillary second molar with a probing depth of 8 mm.After conservative periodontal treatment, oral surgical intervention was performed including open flap debridement and filling the defect with xenograft and plasma rich fibrin.The application of xenograft and Plasma rich fibrin resulted in bone regeneration of the defect and successful fixed prosthodontic solution.Guided bone and soft tissue regeneration using xenograft and fibrin-rich plasma gives successful radiological and clinical signs of bone augmentation and consolidation of defects caused by loss of tooth attachment.

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Section: Introductionmentioning

confidence: 99%

Oral–surgical Treatment of Periodontal Pocket With Guided Bone and Soft Tissue Regeneration

Evrosimovska

Janeva²,

Janeva³

et al. 2022

JMS

View full text Add to dashboard Cite

show abstract

Retracted: Observation on the Effect of Bone Grafting Alone and Guided Tissue Regeneration Combined with Bone Grafting to Repair Periodontal Intraosseous Defects

Medicine¹

2023

Evidence-Based Complementary and Alternative Medicine

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Brief literature review and comprehensive bioinformatics analytics unravel the potential mechanism of curcumin in the treatment of periodontitis

et al. 2023

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Objective Periodontitis is a chronic oral disease prevalent worldwide, and natural products are recommended as adjunctive therapy due to their minor side effects. Curcumin, a widely used ancient compound, has been reported to possess therapeutic effects in periodontitis. However, the exact mechanism underlying its activity remains unclear. In this context, the present study aimed to conduct computational simulations to uncover the potential mechanism of action of Curcumin in the treatment of periodontitis. Materials and methods Single-cell analysis was conducted using a dataset (i.e., GSE164241) curated from the Gene Expression Omnibus (GEO) database through an R package "Seurat package." Bulk RNA sequencing data were curated from GSE10334 and GSE16134 and processed by R package "Limma." Then, the marker genes in the single-cell transcriptome and differentially expressed genes (DEGs) in the bulk transcriptome were integrated. Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) analyses were also carried out to reveal their functionalities. Key targets were mined from their protein–protein interaction (PPI) network topologically. Afterward, molecular docking was performed. The top-ranked pose was subjected to molecular dynamics simulations to investigate the stability of the docking result. Results FOS, CXCL1, CXCL8, and IL1B, were filtered after a series of selected processes. The results of molecular modeling suggested that except for IL1B, the Vena Scores of the rest exceeded -5 kcal/mol. Furthermore, the molecular dynamic simulation indicated that the binding of the CXCL8-Curcumin complex was stable over the entire 100 ns simulation. Conclusion The present study unlocked the binding modes of CXCL1, FOS, and CXCL8 with the Curcumin molecule, which were relatively stable, especially for CXCL8, hindering its promising potential to serve as the critical targets of Curcumin in periodontitis treatment.

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Observation on the Effect of Bone Grafting Alone and Guided Tissue Regeneration Combined with Bone Grafting to Repair Periodontal Intraosseous Defects

Cited by 5 publications

References 25 publications

Oral–surgical Treatment of Periodontal Pocket With Guided Bone and Soft Tissue Regeneration

Oral–surgical Treatment of Periodontal Pocket With Guided Bone and Soft Tissue Regeneration

Retracted: Observation on the Effect of Bone Grafting Alone and Guided Tissue Regeneration Combined with Bone Grafting to Repair Periodontal Intraosseous Defects

Brief literature review and comprehensive bioinformatics analytics unravel the potential mechanism of curcumin in the treatment of periodontitis

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