Data in B-meson decays indicate violations of lepton flavour universality, thereby raising the question about such phenomena in the charm sector. We perform a model-independent analysis of NP contributions in (semi)-leptonic decays of D (s) mesons which originate from c → d¯ ν and c → s¯ ν charge-current interactions. Starting from the most general low-energy effective Hamiltonian containing fourfermion operators and the corresponding short-distance coefficients, we explore the impact of new (pseudo)-scalar, vector and tensor operators and constrain their effects through the interplay with current data. We pay special attention to the elements |V cd | and |V cs | of the Cabibbo-Kobayashi-Maskawa matrix and extract them from the D (s) decays in the presence of possible NP decay contributions, comparing them with determinations utilizing unitarity. We find a picture in agreement with the Standard Model within the current uncertainties. Using the results from our analysis, we make also predictions for leptonic D + (s) → e + ν e modes which could be hugely enhanced with respect to their tiny Standard Model branching ratios. It will be interesting to apply our strategy at the future high-precision frontier.