Observation of the clinical efficacy of isotope phosphorus‐32 dressing combined with diprospan and mucopolysaccharide polysulphate cream in the treatment of keloids

Abstract

Objective The present study aims to investigate the effectiveness, recurrence, and adverse reaction rates of isotope phosphorus‐32 dressings combined with diprospan and mucopolysaccharide polysulphate cream in the treatment of keloids. Methods A total of 80 patients with keloids admitted to the Dermatology Clinic of the Fourth Affiliated Hospital of Harbin Medical University between June 2019 and June 2021 were included in the present study and randomly divided into three groups: Control Group 1 (n = 27), Control Group 2 (n = 25), and the treatment group (n = 28). Patients in Control Group 1 were treated with diprospan combined with mucopolysaccharide polysulphate cream, patients in Control Group 2 were treated with an isotopic phosphorus‐32 dressing combined with mucopolysaccharide polysulphate cream, and patients in the treatment group were treated with an isotopic phosphorus‐32 dressing combined with diprospan and mucopolysaccharide polysulphate cream. The effectiveness, recurrence, and adverse reaction rates were observed in all three groups. Results The treatment group had the most significant decrease in the itching scores. The respective effectiveness, recurrence, and adverse reaction rates were 81.4%, 43.6%, and 74.1% in Control Group 1; 56%, 38.7%, and 64% in Control Group 2; and 96.7%, 11.2%, and 41% in the treatment group. The differences were statistically significant (p < 0.05). Conclusion An isotope phosphorus‐32 dressing combined with diprospan and mucopolysaccharide polysulphate cream keloid treatment delivers a fast onset, good effectiveness, and low recurrence and adverse effect rates.

Efficacy and safety of 1565‐nm nonablative fractional laser combined with mucopolysaccharide polysulfate cream for erythematous acne scars

“…10,11,13,14 Furthermore, it has shown some potential in preventing and treating scars. 15,16 Early treatment of scars can control their further development and shorten the immature phase of scars. Combination therapy using multiple approaches with different mechanisms of action may increase the efficacy of scars.…”

“…It is often used alone or in combination with other options to treat skin diseases such as superficial phlebitis, pressure sores, postoperative edema and ecchymosis, skin contusions, and non‐exudative eczema 10,11,13,14 . Furthermore, it has shown some potential in preventing and treating scars 15,16 …”

“…Moreover, it also suppresses IL-1ß production from keratinocytes 27. Second, MPS cream could repair the damaged skin tissue in acne scars by promoting dermal microcirculation, anticoagulation, and normal connective tissue regeneration action 11,13,16. MPS cream can contribute to dermal microvascular stabilization and barrier integrity 28,29.…”