Observation of terahertz absorption signatures in microliter DNA solutions

Zhang, W.; Brown, E. R.; Rahman, Masudur; Norton, Michael L.

doi:10.1063/1.4775696

Cited by 58 publications

(36 citation statements)

References 13 publications

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“…Alternatively, a photomixing spectrometer is a high-resolution, coherent frequency-domain transceiver and is frequently used to detect spectral signatures of spores because of its excellent spectral resolution (Zhang et al 2013). It generates continuous-wave THz signals by driving a GaAs photoconductor, on which interdigitated metal electrodes are patterned with two frequency-offset lasers.…”

Section: Photomixing Spectrometermentioning

confidence: 99%

“…Two single-mode and temperature-tunable distributedfeedback (DFB) semiconductor lasers are at different frequencies ν ± = ν 0 ± ν THz / 2. A schematic representation of a typical photomixing spectrometer is shown in Fig. 2b (Zhang et al 2013). Two photomixers are used in the system as the transmitter and the receiver, respectively.…”

Section: Photomixing Spectrometermentioning

confidence: 99%

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Terahertz spectroscopy for bacterial detection: opportunities and challenges

Xiang

Yang

Luo

et al. 2016

Appl Microbiol Biotechnol

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The demand for advanced bacterial detection tools is continuously increasing, promoted by its significant benefits in various applications. For instance, in the medical field, these tools would facilitate decision making about more tailored therapies once the infection source has been identified. In the past few years, terahertz (THz = 10(12) Hz) spectroscopy has also shown potential as a novel bacterial detection modality due to its unique advantages. Impressive breakthroughs have been achieved in this field related to bacterial component characterization, spore identification, and cell detection. However, some intrinsic limitations and technical bottlenecks have led to some debates about the practicability of its clinical adoption. In this review, we summarize the progress achieved in this field and discuss some challenges and strategies for future implementation of practical applications.

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Section: Photomixing Spectrometermentioning

confidence: 99%

Section: Photomixing Spectrometermentioning

confidence: 99%

Terahertz spectroscopy for bacterial detection: opportunities and challenges

Xiang

Yang

Luo

et al. 2016

Appl Microbiol Biotechnol

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“…Besides, to provide the needed information the spectral resolution of spectroscopic instruments has to be less than the spectral width of features to be measured. Although multiple resonance absorption lines in sub-THz region have been reported in measurements with appropriate spectral resolution, for example [8][9][10][11][12][13], successful application of THz spectroscopy for DNA, RNA and protein characterization requires deep understanding of relaxation processes of atomic dynamics (displacements) within a macromolecule. The dissipation time is one of the fundamental problems related to THz vibrational modes in biological molecules.…”

mentioning

confidence: 99%

Sub-terahertz Vibrational Spectroscopy with High Resolution for Biological Molecules and Cells Identification

Globus¹

2016

J Biomol Res Ther

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“…Also, it is mentioned that one limitation of this structure is that thicker Polyethylenes (PEs) coatings are not possible because its poor solubility in solvent, thus reducing the described design benefits for the lower THz frequencies. Some practical uses of the CWG are found in [384], [387]- [389]. In [387], an overmoded CWG was part of a vacuum electronic tube source operating at f = 0.65 THz.…”

Section: Metallic (Microwave) Waveguides and Transmission Linesmentioning

confidence: 99%

“…In [388], a corrugated CWG supporting TM modes is visioned as a promising slow-wave structure for high power THz transmission, specially indicated for plasma characterization. In [389], a very sensitive waveguide technique was applied to the THz analysis of DNA solutions, requiring the use of a a = 0.59 mm, 0.13 mm thick brass shim. Finally, in [384] a liquid-nitrogen-cooled compact CW source uses an a = 1.75 mm cooper CWG, Fig.…”

Section: Metallic (Microwave) Waveguides and Transmission Linesmentioning

confidence: 99%

Analysis and design of efficient passive components for the millimeter-wave and THz bands

Verdú¹,

Antonio²

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To my parents, brother and sister."Success is peace of mind which is a direct result of self-satisfaction in knowing you made the effort to become the best of which you are capable."Jonh Wooden "Lo que con mucho trabajo se adquiere, más se ama." Aristóteles AgradecimientosLa realización de esta tesis ha implicado no pocos años de trabajo y esfuerzo. Durante este importante periodo de mi vida han sido muchas las personas han estado a mi lado, brindándome su apoyo, ayuda, cariño y amor. Ya sea de una forma u otra, todas estas personas han contribuido a que este trabajo haya sido posible dando como fruto esta tesis. A todos ellos, me gustaría dedicarles un agradecimiento muy especial de todo corazón.Sin duda alguna, debo dar las gracias en primer lugar a mi director de tesis Mariano Baquero. Mariano, has sido un padre para mí profesionalmente hablando. Te conocí como alumno en las clases de Microondas, en las cuales me abriste la puerta a un conocimiento que me fascinó.Recuerdo perfectamente cuando fui a verte para preguntarte si podrías dirigirme el Proyecto Final de Carrera, y desde ese año 2009 hemos estado trabajando juntos. Quiero agradecerte no sólo haberme dado la oportunidad de trabajar en cada momento en elárea que más me ha gustado, sino el haberte preocupado por mí a nivel personal, velando siempre por mis intereses, ayudándome a desarrollarme personal y profesionalmente. Extiendo en este sentido mi agradecimiento a Miguel Ferrando. Si Mariano es el padre, tu serías sin duda el abuelo. Sin tu ayuda, la beca para la realización de esta tesis y los proyectos que han respaldado la misma no hubieran sido posibles. Tu esfuerzo ha permitido que el Grupo de Radiación Electromagnética (GRE) esté hoy dónde esta y que sus miembros nos beneficiemos de un entorno de trabajo excelente, produciendo trabajo de calidad. Debo agradecerte también tus siempre innovadoras ideas, algunas de las cuales se han convertido en una realidad plasmada en esta tesis.Una mención especial merece Daniel Sánchez. Dani, aunque tu nombre no figure como co-director bien sabes que podría estarlo. Jamás podré agradecerte lo suficiente la ayuda que me has prestado. Cuántas horas dedicadas a enseñarme en un sin fin de aspectos sin esperar nada a cambio, apoyándome también en los momentos difíciles, siempre presentes en una tesis. Bien sabes que lo mismo has hecho con cada uno tus compañeros, por eso eres el pilar del GRE Dani.Otra persona a la que estoy muy agradecido es a Vicente Boria. Tu activa colaboración en la dirección de esta tesis ha sido indispensable para la consecución de los resultados más relevantes de la misma. Sugeriste muy acertadamente una estancia en la Queen's University of Belfast, y me abriste la puerta a nuevas líneas de investigación en las cuales seguimos trabajando actualmente. Gracias por preocuparte por mi a nivel profesional y personal.En elámbito anterior, extiendo los agradecimientos a todo el GRE. It is also very important for me to acknowledge Prof. Vince Fusco. Thank you for hosting me in your group in Belfast ...

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Observation of terahertz absorption signatures in microliter DNA solutions

Cited by 58 publications

References 13 publications

Terahertz spectroscopy for bacterial detection: opportunities and challenges

Terahertz spectroscopy for bacterial detection: opportunities and challenges

Sub-terahertz Vibrational Spectroscopy with High Resolution for Biological Molecules and Cells Identification

Analysis and design of efficient passive components for the millimeter-wave and THz bands

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