Observation of continuous spike-waves during slow sleep in children with myelomeningocele

Battaglia, Domenica; Acquafondata, Celeste; Lettori, Donatella; Tartaglione, Tommaso; Donvito, Valeria; Staccioli, Susanna; Mittica, A.; Guzzetta, Andrea

doi:10.1007/s00381-004-0956-9

Cited by 15 publications

(17 citation statements)

References 15 publications

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“…Only a minority of the affected individuals have underlying structural abnormalities, including cortical dysplasias, in particular polymicrogyria, or thalamic lesions [29,30]. No single genes have been associated to epilepsy with CSWS.…”

Section: Discussionmentioning

confidence: 96%

22q11.2 Microduplication syndrome and epilepsy with continuous spikes and waves during sleep (CSWS). A case report and review of the literature

Valvo¹,

Novara²,

Brovedani³

et al. 2012

Epilepsy & Behavior

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Section: Discussionmentioning

confidence: 96%

22q11.2 Microduplication syndrome and epilepsy with continuous spikes and waves during sleep (CSWS). A case report and review of the literature

Valvo¹,

Novara²,

Brovedani³

et al. 2012

Epilepsy & Behavior

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“…It has been proposed that CSWS could be a manifestation of a pathologic form of the corticothalamic oscillation caused by an early developmental injury to the thalamus. [10][11][12][13] Nonetheless, a detectable thalamic injury is not obvious in a majority of patients with CSWS. 13 We hypothesized that patients with CSWS could have functional thalamic abnormalities not amenable to detection by routine structural neuroimaging techniques, such as computed tomography (CT) or magnetic resonance imaging (MRI).…”

mentioning

confidence: 99%

Thalamic abnormalities in children with continuous spike‐wave during slow‐wave sleep: An F‐18‐fluorodeoxyglucose positron emission tomography perspective

et al. 2015

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SUMMARYObjective: Thalamic injury has been implicated in the development of continuous spike-wave during slow-wave sleep (CSWS) in children with epilepsy. We studied thalamic abnormalities in children with CSWS using F-18-fluorodeoxyglucose (FDG)-positron emission tomography (PET) imaging. Methods: Twenty-three patients (12 male; mean age 9 years) with CSWS and normal thalami on brain magnetic resonance imaging (MRI) underwent FDG-PET. Thalamic glucose metabolism, represented by standardized uptake value normalized to whole brain (nSUV, RT for right thalamus and LT for left thalamus), and its asymmetry-absolute asymmetry index (AAI): |(RT-LT)|*100/ [(RT+LT)/2]-was calculated. These values were compared with those from 10 normal healthy controls (five female; mean age 11.1 years). Results: Thalamic glucose metabolism was abnormal in 18 patients (78.3%). Thalamic nSUV was decreased (n = 6) or increased (n = 1) bilaterally in seven children without any asymmetry. Abnormal thalamic symmetry [AAI = 3.7-31.5% (0.8-3.3% in controls)] was seen in 11 children. Of these, six children had a unilateral thalamic metabolic abnormality (increased metabolism, n = 3 and decreased metabolism, n = 3), whereas 5 of 14 children had abnormal asymmetry index with bilaterally normal (n = 4) or increased (n = 1) thalamic metabolism. No clear association of thalamic metabolic abnormalities was seen with the stage of evolution of CSWS (prodromal, acute, or residual) or with the cortical FDG abnormalities. Significance: Functional thalamic abnormalities, both unilateral and bilateral, are frequently seen in patients with CSWS. FDG-PET is a sensitive and quantifiable modality to detect these changes. KEY WORDS: Continuous spike-wave during slow-wave sleep, Electrical status epilepticus in sleep, Thalamus, F-18-fluorodeoxyglucose positron emission tomography.The association between epilepsy and sleep is well recognized, and activation of epileptiform discharges during non-rapid eye movement (non-REM) sleep is frequently seen.1-3 Continuous spike-wave during slow-wave sleep (CSWS) represents an extreme form of sleep-potentiation of epileptiform activity, manifesting on electroencephalography (EEG) with electrical status epilepticus in sleep (ESES).4,5 CSWS is defined as an age-related epileptic encephalopathy that is characterized by a combination of epilepsy, neuropsychological impairment, and typical EEG findings with a diffuse pattern of spike-waves in ≥85% of slow-wave sleep.6-8 CSWS occurs during early childhood,

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“…[3] Seizure in these patients is mainly related to the hydrocephalus, in particular, to the ventriculoperitoneal shunt and its complications. [34] Considering the fact that these patients had lipomyelomeningocele, which never associated with hydrocephalus, the seizure cannot be attributed to this issue.…”

Section: Discussionmentioning

confidence: 99%

Possible causes of seizure after spine surgery

2010

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Seizure after laminectomy for spinal procedure is very rare and has not been reported after lipomyelomeningocele surgery beforehand. Here, two cases of seizure following laminectomy for lipomyelomeningocele are reported. The exact etiology of the event is unknown but anesthetic material, pneumocephalus, intracranial hypotension subsequent to cerebrospinal fluid leakage after spinal procedures, spinal-induced seizure and the potential toxic effect of fat molecules could be considered.

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Observation of continuous spike-waves during slow sleep in children with myelomeningocele

Cited by 15 publications

References 15 publications

22q11.2 Microduplication syndrome and epilepsy with continuous spikes and waves during sleep (CSWS). A case report and review of the literature

22q11.2 Microduplication syndrome and epilepsy with continuous spikes and waves during sleep (CSWS). A case report and review of the literature

Thalamic abnormalities in children with continuous spike‐wave during slow‐wave sleep: An F‐18‐fluorodeoxyglucose positron emission tomography perspective

Possible causes of seizure after spine surgery

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