Observation�Effect of the Pro12Ala polymorphism of the PPAR-?2 gene on long-term weight change in Finnish non-diabetic subjects

Obesity and Pro12Ala Polymorphism of Peroxisome Proliferator-Activated Receptor-Gamma Gene in Healthy Adults: A Systematic Review and Meta-Analysis

“…Each dataset was treated as a separate comparison in the meta-analysis. Forty studies were on Caucasians [5,8,10,12,25,26,27,28,29,32,33,34,35,36,37,38,39,41,42,43,45,46,47,48,52,53,54,57,60,61,62,63,64,65,66,67,68,69,70], 10 studies were on Asian [31,40,49,50,55,56,58,59,71,72] and 6 studies were on mixed populations [7,30,37,73,74,75]. Between 56 studies, 19 studies provided data on male [10,12,29,33,35,37,40,42,43,47,50,57,60,61,62,65,66,69,71] and 22 studies on female members [10,12,29,32,37,41,42,50,53,54,55,59,60,61,62,64,66,…”

“…Nine cohort studies [12,25,26,27,28,29,30,31,32], 7 population case-control studies [33,34,35,36,37,38,39], 31 cross-sectional studies [5,7,10,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67], and 9 interventional studies [8,68,69,70,71,72,73,74,75] were included in the meta-analysis of the association between PPARγ Pro12Ala polymorphism and obesity. The characteristics and results of the studies are summarized in table 1.…”

The Association between the Pro12Ala Variant in the PPARγ2 Gene and Type 2 Diabetes Mellitus and Obesity in a Chinese Population

“…The PPARγ2 Pro12Ala polymorphism, which is the result of a CCA-to-GCA missense mutation in codon 12 of exon B, encodes the amino-terminal domain defining the adipocyte specific PPARγ2 isoform of the PPARγ gene [6]. The association between the Pro12Ala variant in the PPARγ2 gene and T2DM or obesity have been the most extensively examined in Caucasians [7]–[12]. However, the Ala frequencies have difference among different ethnic groups.…”

FABP-2 and PPAR-γ Haplotype as Risk Factors for Dyslipidemia in a Type 2 Diabetes Mellitus Population of Santa Rosa del Conlara, San Luis, Argentina

“…In general, the frequency of the Ala allele has been reported to be highest in Caucasians [50]. Variations in the allelic frequency of the Pro12Ala polymorphism across different ethnicities and regions could be attributed to genetic variations and to different environmental and lifestyle exposures [51].…”

“…Consistent with our results, Altshuler et al [15] found a significant decrease in diabetes risk associated with the Ala allele in a Caucasian population. In Finnish subjects, the Ala12 variant of the PPAR-γ gene was associated with protection against T2DM [51]. Meta-analyses [4] [52] also showed a significant effect of the Ala allele on lower development of T2DM.…”