Observation and Simulation of the Circulation, Acid-Base Balance, and Response to CO
            <sub>2</sub>
            in Cheyne-Stokes Respiration

Lange, Ramon L.; Botticelli, James T.; Carlisle, R; Tsagaris, Theofilos J.; Horgan, James D.

doi:10.1161/01.cir.37.3.331

Cited by 9 publications

(1 citation statement)

References 16 publications

(11 reference statements)

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“…Increased circulation time from the lungs to the chemoreceptors could contribute to the pathogenesis of CSA-CSR. Indeed, an early study reported increased circulation time in patients with heart failure with CSA-CSR [105]. However, to induce CSA-CSR in dogs, GUYTON et al [106] had to artificially lengthen heart-to-brain circulation time far beyond physiological values of up to several minutes and even then induced CSA-CSR in only approximately one-third of the animals.…”

Section: Role Of Arousal From Sleepmentioning

confidence: 99%

Sleep apnoea and heart failure

et al. 2021

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Heart Failure (HF) and Sleep-Disordered-Breathing (SDB) are two common conditions that frequently overlap and have been studied extensively in the past three decades. Obstructive Sleep Apnea (OSA) may result in myocardial damage, due to intermittent hypoxia increased sympathetic activity and transmural pressures, low-grade vascular inflammation and oxidative stress. On the other hand, central sleep apnoea and Cheyne-Stokes respiration (CSA-CSR) occurs in HF, irrespective of ejection fraction either reduced (HFrEF), preserved (HFpEF) or mildly reduced (HFmrEF). The pathophysiology of CSA-CSR relies on several mechanisms leading to hyperventilation, breathing cessation and periodic breathing. Pharyngeal collapse may result at least in part from fluid accumulation in the neck, owing to daytime fluid retention and overnight rostral fluid shift from the legs. Although both OSA and CSA-CSR occur in HF, the symptoms are less suggestive than in typical (non-HF related) OSA. Overnight monitoring is mandatory for a proper diagnosis, with accurate measurement and scoring of central and obstructive events, since the management will be different depending on whether the sleep apnea in HF is predominantly OSA or CSA-CSR. SDB in HF are associated with worse prognosis, including higher mortality than in patients with HF but without SDB. However, there is currently no evidence that treating SDB improves clinically important outcomes in patients with HF, such as cardiovascular morbidity and mortality.

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Section: Role Of Arousal From Sleepmentioning

confidence: 99%

Sleep apnoea and heart failure

et al. 2021

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The definition of “Cheyne-Stokes rhythms”

Lorenz

Ito

1978

Acta neurochir

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The review of the literature on Cheyne-Stokes respiratory periods reveals enormous variation of the opinions expressed. The original description concerned periodicity characterized by rhythmic changes of respiratory phases and respiratory pauses in a relation of 60 : 15 seconds. In the respiratory phase there were 30 respirations of increasing depths and frequency at the beginning of the phase and decreasing depths and frequency at the end of the phase. Literature data about Cheyne-Stokes respiration comprise a multiplicity of all rhythymic forms. The duration of respiratory cycles varies between 12 and 130 seconds. The relation of the respiratory phase and respiratory pause between 6 : 4 or 75 : 70 seconds, and the number of breaths between 3 and 30 during one respiratory phase. Cheyne-Stokes periods were observed in health subjects as well as in patients with neurological, neurosurgical, cardiac, pulmonary and paediatric diseases. Cheyne-Stokes periods were explained as sequel of prolongation of circulation time between pulmonary alveoli and respiratory centre, through increased sensitivity of the respiratory centre to CO2, diminished sensitivity of the respiratory centre to CO2 and O2-deficit, local blood flow disturbances, section of pathways in the brain stem with disinhibition of basic rhythms, brain immaturity, alterations of consciousness, and respiratory obstructions. Rhythmic changes of the heart beat, of excitability of the heart muscle, of blood pressure, of EEG and of neurological and mental signs were observed. In spite of numerous observations detailed analysis of the respiratory cycle was performed in only a few cases. Major studies are lacking.

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The response of arterial pressure to halothane: A systems analysis

1972

Med. & biol. Engng.

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Observation and Simulation of the Circulation, Acid-Base Balance, and Response to CO ₂ in Cheyne-Stokes Respiration

Cited by 9 publications

References 16 publications

Sleep apnoea and heart failure

Sleep apnoea and heart failure

The definition of “Cheyne-Stokes rhythms”

The response of arterial pressure to halothane: A systems analysis

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Observation and Simulation of the Circulation, Acid-Base Balance, and Response to CO 2 in Cheyne-Stokes Respiration

Cited by 9 publications

References 16 publications

Sleep apnoea and heart failure

Sleep apnoea and heart failure

The definition of “Cheyne-Stokes rhythms”

The response of arterial pressure to halothane: A systems analysis

Contact Info

Product

Resources

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Observation and Simulation of the Circulation, Acid-Base Balance, and Response to CO ₂ in Cheyne-Stokes Respiration