Observation and analysis of 26 cases of asymptomatic SARS-COV2 infection

Zhou, Juan; Tan, Yulong; Li, Dan; He, Xiaojin; Tan, Yuan; Long, Ya‐Qiu

doi:10.1016/j.jinf.2020.03.028

Cited by 14 publications

(12 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ultimately, an optimal view is asymptomatic cases may account for 60% of infections. However, recent research and case reports have confirmed that asymptomatic or pre-symptomatic cases can shed enough quantify of virus to be infectious [5][6][7][8]10]. Furthermore, if the infectivity of asymptomatic cases is similar to that of symptomatic cases, a faster epidemic will occur.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Modeling Return of the Epidemic: Impact of Population Structure, Asymptomatic Infection, Case Importation and Personal Contacts

2020

Preprint

View full text Add to dashboard Cite

Background: Proactive interventions have halted the pandemic of coronavirus infected disease in some regions. However, without reaching herd immunity, the return of epidemic is possible.We investigate the impact of population structure, case importation, asymptomatic cases, and the number of contacts on a possible second wave of epidemic through mathematical modelling.Methods: we built a modified Susceptible-exposed-Infectious-Removed (SEIR) model with parameters mirroring those of the COVID-19 pandemic and reported simulated characteristics of epidemics for incidence, hospitalizations and deaths under different scenarios. Results:A larger percent of old people leads to higher number of hospitalizations, while a large percent of prior infection will effectively curb the epidemic. The number of imported cases and the speed of importation have small impact on the epidemic progression. However, a higher percent of asymptomatic cases slows the epidemic down and reduces the number of hospitalizations and deaths at the epidemic peak. Finally, reducing the number of contacts among young people alone has moderate effects on themselves, but little effects on the old population.However, reducing the number of contacts among old people alone can mitigate the epidemic significantly in both groups, even though young people remain active within themselves.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Two important factors may contribute a second wave of epidemic. First, unlike the 2003 SARS epidemic in which mainly symptomatic cases are infectious [4], asymptomatic infection of the SARS-CoV2 can transmit disease [5][6][7][8][9]. Studies have detected virus shedding in nasopharyngeal swap samples among asymptomatic cases [10].…”

Section: Introductionmentioning

confidence: 99%

Modeling Return of the Epidemic: Impact of Population Structure, Asymptomatic Infection, Case Importation and Personal Contacts

2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Notably in three studies, imaging findings were not linked to specific cases, so they were not included in the secondary analysis. 16,20,21 CT findings are described in detail in Table 1. The most common CT finding in all subgroup categories was GGO and was present alone (in 67/231 patients) or together with other findings including consolidation shadow (22/231 patients), stripe shadows (7/231 patients) and interlobular septal thickening (8/231 patients).…”

Section: Study Characteristics and Findingsmentioning

confidence: 99%

“…5,16e19,21 The findings were most commonly peripheral and were bilateral or unilateral (mostly involving a single lobe). 16,17,19,21…”

Section: Study Characteristics and Findingsmentioning

confidence: 99%

Chest CT findings in asymptomatic cases with COVID-19: a systematic review and meta-analysis

et al. 2020

View full text Add to dashboard Cite

To determine the overall rate of chest imaging findings in asymptomatic cases, describe the most common patterns found, and determine the rate of later symptom development in these initially asymptomatic cases. MATERIALS AND METHODS: The PubMed and EMBASE databases were searched until 1 May 2020, for studies examining the proportion of positive chest imaging findings in asymptomatic cases diagnosed with COVID-19 and a random-effects meta-analysis of proportions was performed. Heterogeneity was assessed using the I 2 statistic. RESULTS: Among 858 non-duplicate studies, seven studies with a total of 231 asymptomatic cases met the inclusion criteria. In the primary analysis, the pooled estimate of the overall rate of positive chest computed tomography (CT) findings among asymptomatic cases was 63% (95% confidence interval [CI]: 44e78%). Among 155/231 cases that were followed up for later symptom development, 90/155 remained asymptomatic and 65/155 developed symptoms during the study period (that ranged between seven and 30 days of follow-up). The pooled estimate of the rate of positive chest CT findings was 62% (95% CI: 38e81%) in cases that remained asymptomatic, while it was 90% (95% CI: 49e99%) in cases that developed symptoms. Among CT findings, the pooled estimate of the overall rate of ground-glass opacities (GGO) at CT alone was 71% (95% CI: 50e86%). Among other CT findings reported, 22/231 patients had GGO with consolidation, 7/231 patients had stripe shadows with or without GGO, and 8/231 patients had GGO with interlobular septal thickening. Among initially asymptomatic cases with positive CT findings, the pooled estimate of the overall rate of later symptom development was 26% (95% CI: 14e43%). CONCLUSION: In COVID-19, asymptomatic cases can have positive chest CT findings, and COVID-19 should be considered among cases with CT abnormalities even when there are no other symptoms. There is a need for close clinical monitoring of asymptomatic cases with radiographic findings as a significant percentage will develop symptoms.

show abstract

“…5 Evidence of asymptomatic COVID-19 infection has been reported in several studies that a substantial portion of COVID-19 patients remained asymptomatic at the end of their isolation period. [6][7][8][9][10][11] With regard to asymptomatic transmission, there is some evidence of transmission from people who are asymptomatic and never develop symptoms, [12][13][14][15] and more evidence of transmission from people who are in their incubation period (ie, people who transmit infection while asymptomatic, but prior to their development of symptoms). 6,12,[16][17][18][19][20][21] These evidences imply that in countries like Ethiopia, where the capacity to conduct mass testing is lacking and contact tracing is not very effective, asymptomatic and pre-symptomatic cases act as silent spreaders and this underlines the importance of social distancing, regular hand washing and good hygiene, and mask wearing to be practiced primarily among the general public.…”

Section: Introductionmentioning

confidence: 99%

<p>Compliance with COVID-19 Preventive and Control Measures among Food and Drink Establishments in Bench-Sheko and West-Omo Zones, Ethiopia, 2020</p>

Qanche¹,

Asefa²,

Nigussie³

et al. 2020

IJGM

View full text Add to dashboard Cite

Observation and analysis of 26 cases of asymptomatic SARS-COV2 infection

Cited by 14 publications

References 5 publications

Modeling Return of the Epidemic: Impact of Population Structure, Asymptomatic Infection, Case Importation and Personal Contacts

Modeling Return of the Epidemic: Impact of Population Structure, Asymptomatic Infection, Case Importation and Personal Contacts

Chest CT findings in asymptomatic cases with COVID-19: a systematic review and meta-analysis

<p>Compliance with COVID-19 Preventive and Control Measures among Food and Drink Establishments in Bench-Sheko and West-Omo Zones, Ethiopia, 2020</p>

Contact Info

Product

Resources

About