Oblongolides from the Endophytic Fungus Phomopsis sp. BCC 9789

Abstract

Six new oblongolides, W1, W2, X, Y, and Z (1-3, 6, 7) and 2-deoxy-4alpha-hydroxyoblongolide X (4), and the known compounds oblongolide (8), oblongolides T, C, and Q (5, 9, 10), and (-)-5-methylmellein were isolated from the endophytic fungus Phomopsis sp. BCC 9789. Compound 7 showed anti-HSV-1 activity (IC50=14 microM) and cytotoxic activities against KB, BC, NCI-H187, and nonmalignant (Vero) cell lines with respective IC50 values of 37, 26, 32, and 60 microM. Cytotoxic activity against the BC cell line was also observed for compound 6, with an IC50 value of 48 microM.

Homoharringtonine production by endophytic fungus isolated from Cephalotaxus hainanensis Li

“…The fungus was cultured and the metabolites were extracted from fermentation broth as previously described (Bunyapaiboonsri et al 2010;Chi et al 2005), with minor modifications. Briefly, the fungus grew on CYA medium at 25°C for 10 days followed by analysis on the morphology of its mycelia and spores.…”

Diversity and Ecological Significance of Fungal Endophyte Natural Products

“…of Camptotheca acuminate [78], and Phomopsis sp. of wild banana leafs (Musa acuminata) [81], along with many diversely substituted analogs (30)(31)(32)(33). Some of them exhibited moderate antibacterial, antialgal, and antifungal properties.…”

Three New Chromone Derivatives Produced by Phomopsis sp. HNY29‐2B from Acanthus ilicifolius Linn.

“…widely exists in most plants. It has been witnessed to be a rich source of novel active metabolites, including antibiotic phompsichalasin, [1] antifungal phomodiol [2] and phomoxanthone A, [3] antimicrotubule phomosidin, [4] anti-inflammatory phomol, [5] cytotoxic mycoepoxydiene, [6] dicerandrols [7] and oblongolides, [8] and antimalarial phomxanthones. [9] As part of our ongoing investigation on new biologically active secondary metabolites from mangrove endophytic fungi, [10][11][12][13][14][15][16] a mangrove fungus Phomosis sp.…”