Objectively Measured Sedentary Time, Physical Activity, and Metabolic Risk

Healy, Geneviève N.; Wijndaele, Katrien; Dunstan, David W.; Shaw, Jonathan E.; Salmon, Jo; Zimmet, Paul; Owen, Neville

doi:10.2337/dc07-1795

Cited by 915 publications

(820 citation statements)

References 18 publications

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“…This is consistent with previous observations that sedentary behavior was strongly associated with several glycemic traits,30, 31, 32 though its association with HbA 1c levels has not been well studied. A previous cross‐sectional study reported that objectively measured sedentary behavior showed a trend for association with elevated HbA 1c in 394 newly diagnosed adults with diabetes mellitus,10 whereas a recent study found that there were no cross‐sectional or 5‐year longitudinal associations between objectively measured sedentary time and HbA 1c in young adults 33.…”

Section: Discussionsupporting

confidence: 92%

“…Further analysis confirmed the strong association between objectively measured sedentary behavior and triglyceride levels, which was previously observed in individuals both with and without diabetes mellitus 10, 22, 30, 32, 34, 35. This is consistent with the potential mechanism that reduced skeletal muscle contractions from prolonged sedentary behavior may depress uptake of plasma triglycerides and triglycerides‐derived fatty acid into skeletal muscle through suppression of lipoprotein lipase activity 36, 37.…”

Section: Discussionsupporting

confidence: 85%

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Objectively Measured Sedentary Time and Cardiovascular Risk Factor Control in US Hispanics/Latinos With Diabetes Mellitus: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Wang

Strizich

Hua

et al. 2017

JAHA

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BackgroundCardiovascular disease (CVD) risk factor control is a cornerstone of diabetes mellitus management. Little is known about relationships of objectively measured sedentary time and physical activity with major CVD risk factor control in individuals with diabetes mellitus. We examined associations of objectively measured sedentary time and moderate‐to‐vigorous physical activity with reaching major CVD risk factor control goals among US Hispanic/Latino adults with diabetes mellitus.Methods and ResultsThis cross‐sectional analysis included 1699 participants with diabetes mellitus from the Hispanic Community Health Study/Study of Latinos (2008–2011). Logistic regression models were used to estimate the odds ratios (ORs) of meeting the following 5 major CVD risk factor control goals: hemoglobin A1c <7.0%; systolic/diastolic blood pressure <140/80 mm Hg; triglycerides <150 mg/dL; low‐density lipoprotein cholesterol <100 mg/dL; and high‐density lipoprotein cholesterol >40/50 mg/dL for men/women. After adjustment for covariates including moderate‐to‐vigorous physical activity, less sedentary time was associated with increased odds of reaching hemoglobin A1c (OR=1.76 [95% CI: 1.10, 2.82]) and triglyceride control goals (OR=2.16 [1.36, 3.46]), and reaching ≥3 CVD risk factor control goals (OR=2.08 [1.34, 3.23]) (all ORs for comparisons of extreme tertiles of sedentary time). Moderate‐to‐vigorous physical activity was not associated with reaching any CVD risk factor control goals. Substituting 60‐min/day of sedentary time with light‐intensity physical activity was associated with increased odds of reaching hemoglobin A1c (OR=1.18 [1.04, 1.35]), high‐density lipoprotein cholesterol (OR=1.17 [1.04, 1.32]), and triglyceride (OR=1.20 [1.05, 1.36]) control goals.ConclusionsAmong US Hispanic/Latino adults with diabetes mellitus, less sedentary time, but not moderate‐to‐vigorous physical activity, was associated with improved CVD risk factor control, specifically in reaching hemoglobin A1c and triglyceride control goals.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 85%

Objectively Measured Sedentary Time and Cardiovascular Risk Factor Control in US Hispanics/Latinos With Diabetes Mellitus: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Wang

Strizich

Hua

et al. 2017

JAHA

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“…9,[21][22][23][24][25][26] For example, British researchers reported that each additional hour of sedentary time is associated with a 1.89cm larger WC in 30 to 80 year olds with newly diagnosed type 2 diabetes. 22 Although accelerometers may not directly measure sitting, these cumulative findings suggest associations between sedentary time and WC and BMI.…”

Section: Discussionmentioning

confidence: 99%

Desk-Based Occupational Sitting Patterns

Ryde

Brown

Peeters

et al. 2013

American Journal of Preventive Medicine

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Background: Prolonged, uninterrupted sitting time is associated with poor health outcomes.As most sitting time occurs at work, accurate, objective measurement of occupational sitting patterns is required to fully understand its effects on employee health. Purpose:The purpose of this study was to examine associations between desk-based sitting patterns, waist circumference (WC) and body mass index (BMI).Methods: Participants were full-time, office-based employees (N=105; mean age 40.9±11.5 years; BMI 26.1±3.9, 65% women). Sitting patterns (total desk-based sitting time and number of times employees got up from their desk) were assessed for five days using an objective measure of desk-based sitting, the sitting pad. WC, height and weight were measured, and BMI calculated (weight/height 2 ). Associations between sitting patterns, WC and BMI were tested using logistic regression models. Data were collected and analysed between 2011/12.Results: Those with high sitting time at their desk were 2.7 times (95% CI: 1.3 to 6.3) more likely to have WC ≥94 cm (men) or ≥80cm (women), and 9.0 times (95% CI: 1.9 to 41.9) more likely to have BMI ≥30 than those with lower sitting time. There were no significant associations between the number of times employees got up from sitting at their desk and WC or BMI. Conclusion:High desk-based sitting time was associated with increased likelihood of weight related health outcomes whereas frequency of getting up from sitting at the desk was not.3

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“…While the true incidence of type 2 diabetes is likely to be under-reported, it has been estimated that by the year 2025, approximately 300 million people worldwide will be afflicted with this condition [3]. The proliferation of the rate of diagnosis of type 2 diabetes (and associated conditions) stems from the readiness of industrialised and developing nations alike to adopt a sedentary lifestyle in the face of excess energy intake [4][5][6][7]. While more than a half century of evidence from epidemiological, experimental and clinical trials pinpoints a positive correlation between dietary intake and disease risk, it has only recently been recognised that a physically inactive lifestyle rapidly initiates maladaptations that cause chronic disease [8][9][10].…”

Section: Introductionmentioning

confidence: 99%