Objectively Measured Physical Activity and Sedentary Time Are Associated With Cardiometabolic Risk Factors in Adults With Prediabetes: The PREVIEW Study

Swindell, Nils; Mackintosh, Kelly A.; McNarry, Melitta A.; Stephens, Jeffrey W.; Sluik, Diewertje; Fogelholm, Mikael; Drummen, Mathijs; Macdonald, I. A.; Martínez, J. Alfredo; Handjieva‐Darlenska, Teodora; Poppitt, Sally D.; Brand-Miller, Jennie; Larsen, Thomas Meinert; Raben, Anne; Stratton, Gareth

doi:10.2337/dc17-1057

Cited by 34 publications

(42 citation statements)

References 33 publications

(42 reference statements)

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“…Although physical activity research has typically focused on MVPA, emerging evidence suggests that light intensity physical activity (LIPA) is associated with better cardiometabolic health, lower incidence of type 2 diabetes and all-cause mortality after adjusting for MVPA [2][3][4]. On the other hand, sedentary time is adversely associated with cardio-metabolic health [5,6], incidence of type 2 diabetes, cardiovascular disease [7] and all-cause mortality [8] independent of MVPA. Additionally, there is some evidence that both short and long sleep duration are adversely associated with body mass index (BMI), impaired glucose metabolism and blood pressure [9].…”

Section: Introductionmentioning

confidence: 99%

Compositional analysis of the associations between 24-h movement behaviours and cardio-metabolic risk factors in overweight and obese adults with pre-diabetes from the PREVIEW study: cross-sectional baseline analysis

Swindell

Rees

Fogelholm

et al. 2020

Int J Behav Nutr Phys Act

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Background: Physical activity, sedentary time and sleep have been shown to be associated with cardio-metabolic health. However, these associations are typically studied in isolation or without accounting for the effect of all movement behaviours and the constrained nature of data that comprise a finite whole such as a 24 h day. The aim of this study was to examine the associations between the composition of daily movement behaviours (including sleep, sedentary time (ST), light intensity physical activity (LIPA) and moderate-to-vigorous activity (MVPA)) and cardio-metabolic health, in a cross-sectional analysis of adults with pre-diabetes. Further, we quantified the predicted differences following reallocation of time between behaviours. Methods: Accelerometers were used to quantify daily movement behaviours in 1462 adults from eight countries with a body mass index (BMI) ≥25 kg·m − 2 , impaired fasting glucose (IFG; 5.6-6.9 mmol·l − 1 ) and/or impaired glucose tolerance (IGT; 7.8-11.0 mmol•l − 1 2 h following oral glucose tolerance test, OGTT). Compositional isotemporal substitution was used to estimate the association of reallocating time between behaviours. (Continued on next page)Results: Replacing MVPA with any other behaviour around the mean composition was associated with a poorer cardio-metabolic risk profile. Conversely, when MVPA was increased, the relationships with cardiometabolic risk markers was favourable but with smaller predicted changes than when MVPA was replaced. Further, substituting ST with LIPA predicted improvements in cardio-metabolic risk markers, most notably insulin and HOMA-IR.Conclusions: This is the first study to use compositional analysis of the 24 h movement composition in adults with overweight/obesity and pre-diabetes. These findings build on previous literature that suggest replacing ST with LIPA may produce metabolic benefits that contribute to the prevention and management of type 2 diabetes. Furthermore, the asymmetry in the predicted change in risk markers following the reallocation of time to/from MVPA highlights the importance of maintaining existing levels of MVPA.Trial registration: ClinicalTrials.gov (NCT01777893).

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Section: Introductionmentioning

confidence: 99%

Compositional analysis of the associations between 24-h movement behaviours and cardio-metabolic risk factors in overweight and obese adults with pre-diabetes from the PREVIEW study: cross-sectional baseline analysis

Swindell

Rees

Fogelholm

et al. 2020

Int J Behav Nutr Phys Act

Self Cite

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“…In addition, recent reviews show beneficial associations also of light-intensity physical activity (LIPA) with cardiometabolic biomarkers [3,4] and detrimental health associations with sedentary behavior (SB) [5,6]. In the past decade the codependency of these behaviors (MVPA, LIPA, SB) has been dealt with by adjusting for time spent in the other behaviors [3,[5][6][7]. The relative contribution of these behaviors on cardiometabolic biomarkers is still to be explained [7].…”

Section: Introductionmentioning

confidence: 99%

“…In the past decade the codependency of these behaviors (MVPA, LIPA, SB) has been dealt with by adjusting for time spent in the other behaviors [3,[5][6][7]. The relative contribution of these behaviors on cardiometabolic biomarkers is still to be explained [7].…”

Section: Introductionmentioning

confidence: 99%

Associations of physical activity and sedentary behavior with cardiometabolic biomarkers in prediabetes and type 2 diabetes: a compositional data analysis

Rossen

Rosen

Johansson

et al. 2019

The Physician and Sportsmedicine

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Objectives: To investigate the associations between objectively measured sedentary behavior (SB), light-intensity physical activity (LIPA) and moderate-to-vigorous physical activity (MVPA) and cardiometabolic and endocrine biomarkers, and to estimate the associations of reallocating time from one behavior to another with cardiometabolic and endocrine biomarkers. Methods: Baseline data from participants diagnosed with prediabetes or type 2 diabetes, n = 175, 58% men, mean (SD) age = 64.4 (7.7), recruited to a physical activity intervention was used. Time spent in SB, LIPA and MVPA was measured by accelerometer and transformed into isometric log-ratio coordinates. The associations between time spent in SB, LIPA and MVPA and biomarkers were examined by linear regression models. The change in each outcome of reallocating time between the three behaviors was estimated. Results: The findings show strong positive associations of time spent in MVPA and negative associations of time spent in SB relative to time spent in the other behaviors with sagittal abdominal diameter (SAD) and homeostasis model assessment for insulin resistance (HOMA-IR) and negative associations of time spent in SB with high-density lipoprotein (HDL) cholesterol. Theoretically, reallocation of 19 minutes MVPA to SB or to LIPA was associated with a 17% and 17% larger SAD, 39% and 36% larger HOMA-IR values and 3.3% and 2.3% lower levels of HDL, respectively. Conclusion: In conclusion, our analysis from a time-use perspective supports the current evidence that sedentary time is devastating for the cardiometabolic health. While LIPA probably requires more time, maintaining or increasing time in MVPA are the most important features of the time use behaviors when promoting a favorable cardiometabolic risk profile in adults with prediabetes and type 2 diabetes. Trial registration: ClinicalTrials.gov, NCT02374788. Registered 2 March 2015-Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02374788 ARTICLE HISTORY

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“…In adults with prediabetes, objectively measured physical activity and sedentary time have been found to have associated with cardiometabolic risk markers. [ 632 633 ] Fixed low-energy diet has been shown to induce an overall 11% weight loss and showed significant improvements in insulin resistance; men appeared to benefit more than women. [ 634 ] Therefore the panel suggests that prescribing a combination of aerobic and resistance training exercises in individuals with T2DM can improve metabolic control while reducing obesity and its related complications.…”

Section: Onsiderationsmentioning

confidence: 99%

RSSDI-ESI clinical practice recommendations for the management of type 2 diabetes mellitus 2020

Chawla

Madhu

Makkar

et al. 2020

Indian J Endocr Metab

100

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Objectively Measured Physical Activity and Sedentary Time Are Associated With Cardiometabolic Risk Factors in Adults With Prediabetes: The PREVIEW Study

Cited by 34 publications

References 33 publications

Compositional analysis of the associations between 24-h movement behaviours and cardio-metabolic risk factors in overweight and obese adults with pre-diabetes from the PREVIEW study: cross-sectional baseline analysis

Compositional analysis of the associations between 24-h movement behaviours and cardio-metabolic risk factors in overweight and obese adults with pre-diabetes from the PREVIEW study: cross-sectional baseline analysis

Associations of physical activity and sedentary behavior with cardiometabolic biomarkers in prediabetes and type 2 diabetes: a compositional data analysis

RSSDI-ESI clinical practice recommendations for the management of type 2 diabetes mellitus 2020

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