Objective prevalence of insomnia in the São Paulo, Brazil epidemiologic sleep study

Castro, Laura De; Poyares, Dalva; Léger, Damien; Bittencourt, Lia; Tufik, Sérgio

doi:10.1002/ana.23945

Cited by 102 publications

(58 citation statements)

References 42 publications

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“…Many recent studies have reported that between 20 and 30% of adults currently sleep less than 6 hours per 24-hour period, resulting in a growing sleep deficit [41, 42]. While some data reported hyperalgesic changes using QST after one night of total sleep deprivation, our data indicated that one night of partial sleep deprivation, i.e.…”

Section: Discussioncontrasting

confidence: 64%

Napping Reverses Increased Pain Sensitivity Due to Sleep Restriction

et al. 2015

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Study ObjectiveTo investigate pain sensitivity after sleep restriction and the restorative effect of napping.DesignA strictly controlled randomized crossover study with continuous polysomnography monitoring was performed.SettingLaboratory-based study.Participants11 healthy male volunteers.InterventionsVolunteers attended two three-day sessions: “sleep restriction” alone and “sleep restriction and nap”. Each session involved a baseline night of normal sleep, a night of sleep deprivation and a night of free recovery sleep. Participants were allowed to sleep only from 02:00 to 04:00 during the sleep deprivation night. During the “sleep restriction and nap” session, volunteers took two 30-minute naps, one in the morning and one in the afternoon.Measurements and ResultsQuantitative sensory testing was performed with heat, cold and pressure, at 10:00 and 16:00, on three areas: the supraspinatus, lower back and thigh. After sleep restriction, quantitative sensory testing revealed differential changes in pain stimuli thresholds, but not in thermal threshold detection: lower back heat pain threshold decreased, pressure pain threshold increased in the supraspinatus area and no change was observed for the thigh. Napping restored responses to heat pain stimuli in the lower back and to pressure stimuli in the supraspinatus area.ConclusionsSleep restriction induces different types of hypersensitivity to pain stimuli in different body areas, consistent with multilevel mechanisms, these changes being reversed by napping. The napping restorative effect on pain thresholds result principally from effects on pain mechanisms, since it was independent of vigilance status.

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Section: Discussioncontrasting

confidence: 64%

Napping Reverses Increased Pain Sensitivity Due to Sleep Restriction

et al. 2015

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“…Previous studies have examined the concept of objective short sleep duration based on only one PSG night 24 . Although we have used data from more than one PSG night to classify short sleep duration, we still acknowledge that this data may not fully represent the sleep habits of subjects.…”

Section: Discussionmentioning

confidence: 99%

Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia

D’Aurea¹,

Poyares²,

Piovezan³

et al. 2015

Arq. Neuro-Psiquiatr.

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Objective To evaluate the association between objective short sleep duration in patients with insomnia and changes in blood parameters related to hypothalamic-pituitary-adrenal (HPA) axis activity.Method A cross-sectional pilot study was conducted in 30 middle-aged adults with chronic insomnia who were divided into 2 groups according to polysomnography (PSG) total sleep time (TST) (TST > 5h and < 5h). All patients underwent subjective analysis of sleep quality, anthropometric measurements, PSG, and determination off asting blood parameters.Results The results revealed lower sleep efficiency and higher sleep latency for those with a TST < 5h. The subjective sleep quality was worse in the TST < 5h. Significantly, higher glucose and cortisol levels were observed with a TST < 5h. Glucose, cortisol and ACTH levels were inversely correlated with the PSG total sleep time.Conclusion Patients with insomnia with objective short sleep duration had HPA-associated endocrine and metabolic imbalances chronically linked to increases in cardiovascular risk observed with this more severe insomnia phenotype.

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“…Individuals with insomnia frequently have a non-restorative sleep and may present early awakenings. Among the predisposing and risk factors are female gender, anxiety and depression (Castro et al 2013).…”

Section: Sleep Regulationmentioning

confidence: 99%

The interfaces between vitamin D, sleep and pain

Oliveira

Hirotsu

Tufik

et al. 2017

Journal of Endocrinology

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The role of vitamin D in osteomineral metabolism is well known. Several studies have suggested its action on different biological mechanisms, such as nociceptive sensitivity and sleep-wake cycle modulation. Sleep is an important biological process regulated by different regions of the central nervous system, mainly the hypothalamus, in combination with several neurotransmitters. Pain, which can be classified as nociceptive, neuropathic and psychological, is regulated by both the central and peripheral nervous systems. In the peripheral nervous system, the immune system participates in the inflammatory process that contributes to hyperalgesia. Sleep deprivation is an important condition related to hyperalgesia, and recently it has also been associated with vitamin

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Objective prevalence of insomnia in the São Paulo, Brazil epidemiologic sleep study

Abstract: The prevalence of objective insomnia assessed by polysomnography was higher than the prevalence of subjective insomnia according to DSM-IV-validated questionnaires. Clinical trials.gov ID: NCT00596713.

Cited by 102 publications

References 42 publications

Napping Reverses Increased Pain Sensitivity Due to Sleep Restriction

Napping Reverses Increased Pain Sensitivity Due to Sleep Restriction

Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia

The interfaces between vitamin D, sleep and pain

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