Objective polysomnography-based sleep features and major depressive disorder subtypes in the general population

Solelhac, Geoffroy; Berger, Mathieu; Strippoli, Marie-Pierre F.; Marchi, Nicola Andrea; Stephan, Aurélie; Petit, Jean‐Marie; Bayon, Virginie; Imler, Théo; Haba‐Rubio, José; Raffray, Tifenn; Vollenweider, Péter; Marques‐Vidal, Pedro; Waeber, Gérard; Léger, Damien; Siclari, Francesca; Geoffroy, Pierre A.; Preisig, Martin; Heinzer, Raphaël

doi:10.1016/j.psychres.2023.115213

Cited by 8 publications

(3 citation statements)

References 48 publications

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“…54 Another plausible explanation is that the sample comprised newly followed ambulatory patients, possibly resulting in less objective sleep disturbance, as reported in MDD patients from the general population. 55 Finally, we observed a positive association between the duration of SWS and higher working memory. Previous studies have not explored this association in patients with MDD or CI.…”

Section: Discussionsupporting

confidence: 50%

“…This effect may arise from maladaptive associations between the insomniacs’ sleep issues and their familiar sleep environment, which are disrupted by a new sleep setting in the laboratory where patients appear to fall asleep more readily 54 . Another plausible explanation is that the sample comprised newly followed ambulatory patients, possibly resulting in less objective sleep disturbance, as reported in MDD patients from the general population 55 …”

Section: Discussionmentioning

confidence: 99%

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Polysomnographic parameters associated with cognitive function in patients with major depression and insomnia

Olivera-López,

Jiménez-Genchi,

Ortega-Robles

et al. 2024

CNS Spectr.

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Objective To examine whether objective sleep parameters are associated with cognitive function (CF) in patients with major depressive disorder (MDD) with chronic insomnia (CI) and whether the severity of these disorders is related to CF. Method Thirty patients with MDD with CI attending a tertiary care institution underwent two consecutive nights of polysomnographic (PSG) recording and a battery of neuropsychological tests, which included episodic memory, sustained attention, working memory, and executive function. The severity of MDD and CI was assessed by clinical scales. We examined the relationship between PSG parameters and CF, as well as whether the severity of the disorders is related to CF. Results Linear regression analysis revealed that total sleep time (TST) was positively associated with higher learning and recall of episodic memory, as well as better attention. Slow-wave sleep (SWS) showed a positive association with better working memory. Furthermore, wake after sleep onset (WASO) was negatively associated with episodic memory and lower attention. No significant relationships were found between the severity of MDD or CI with CF. Conclusion Both sleep duration and depth are positively associated with several aspects of CF in patients with MDD with CI. Conversely, a lack of sleep maintenance is negatively related to CF in these patients. These findings could help identify modifiable therapeutic targets to reduce CF impairment.

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Section: Discussionsupporting

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Polysomnographic parameters associated with cognitive function in patients with major depression and insomnia

Olivera-López,

Jiménez-Genchi,

Ortega-Robles

et al. 2024

CNS Spectr.

View full text Add to dashboard Cite

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“…Unfortunately, these promising results on increased REM sleep pressure as a predictor of depressive illness were not further pursued, thus being neither confirmed nor disproven until now, although very recently, one big PSG study of 1820 community-dwelling individuals pointed once more to increased REM density as a trait marker of depression [16]. In general, however, studies using PSG in psychiatric patients have consistently declined following the turn of the millennium (e.g., for major depression, from 76 PubMed-listed papers between 1991 and 2000 to 47 from 2011 to 2020).…”

Section: Rem Sleep Pressure In Depressionmentioning

confidence: 99%

The Past and Future of Psychiatric Sleep Research

Pollmächer

2023

CTN

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Sleep studies in psychiatric disorders date back to the first half of the 20th century. So far, success in establishing disease-specific sleep-related biomarkers has been quite limited. This is particularly obvious regarding insomnia, where there is no reliable correlation between subjective complaints and physiological measures of sleep. Finally, it must be acknowledged that the physiology of sleep and wakefulness and their subjective perception are essentially independent dimensions. Still, however, these dimensions are mixed up in clinical practice and research. This creates confusion, can be harmful for patients, and is identified as a major obstacle for successful psychiatric sleep research. It is proposed here that future sleep research should treat physiological sleep as a variable in psychiatric disorders which, independently of patient perception, has a transdiagnostic value, as was already proposed a decade ago by the Research Domain Criteria.

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Influence of Regular Physical Activity on Sleep

McGranahan,

O’Connor

2024

Current Topics in Behavioral Neurosciences

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Objective polysomnography-based sleep features and major depressive disorder subtypes in the general population

Cited by 8 publications

References 48 publications

Polysomnographic parameters associated with cognitive function in patients with major depression and insomnia

Polysomnographic parameters associated with cognitive function in patients with major depression and insomnia

The Past and Future of Psychiatric Sleep Research

Influence of Regular Physical Activity on Sleep

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