Objective measures of sleep in fibromyalgia syndrome: Relationship to clinical, psychiatric, and immunological variables

Çetin, Buğra; Güleç, Hüseyin; Toktaş, Hayal Ergin; Ulutaş, Özgür; Yılmaz, Seda Güleç; İsbır, Turgay

doi:10.1016/j.psychres.2018.02.057

Cited by 6 publications

(6 citation statements)

References 36 publications

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“…Previous studies indicated a possible link between improvement in subjective sleep outcomes and pain reduction in patients with FMS [ 34 , 45 ]. Of note, the role of sleep quality in controlling pain and the pathophysiology of FMS suggests the need to develop alternatives to improve sleep quality.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Whole-Body Vibration Training on Brain-Derived Neurotrophic Factor, Clinical and Functional Outcomes, and Quality of Life in Women with Fibromyalgia Syndrome: A Randomized Controlled Trial

Ribeiro

Lacerda

Santos

et al. 2021

Journal of Healthcare Engineering

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This study aimed to investigate the efficacy of whole-body vibration training (WBVT) on blood brain-derived neurotrophic factor (BDNF) levels and determine the clinical and functional outcomes in patients with fibromyalgia syndrome (FMS). Thirty-two women with FMS were randomized into an intervention group (IG), receiving 6 weeks of WBVT, or a control group (CG) with no intervention. The outcomes at the baseline and follow-up in both groups included blood BDNF levels, sit-to-stand test (STS), 6-minute walk test (6MWT), Fibromyalgia Impact Questionnaire (FIQ), Pittsburgh Sleep Quality Index (PSQI), Beck Depression Inventory (BDI), and visual analogue scale (VAS). WBVT resulted in a group-by-time interaction effect. Thus, after the intervention time, the IG had increased blood BDNF levels ( p = 0.045 ), a higher number of repetitions on the STS test ( p = 0.011 ), and increased walking distance on the 6MWT ( p = 0.010 ), compared to CG. Moreover, there was a reduction in the scores of the FIQ ( p = 0.001 ), the PSQI ( p = 0.001 ), the BDI ( p = 0.017 ), and pain assessed using VAS ( p = 0.008 ) in IG. The results demonstrate that WBVT promotes an increase in blood BDNF levels, with concomitant improvement in lower limb muscle strength, aerobic capacity, clinical symptoms, and quality of life in women with FMS. This trial is registered with Brazilian Clinical Trials Registry (REBEC; RBR-38nbbx) (https://ensaiosclinicos.gov.br/rg/RBR-38nbbx).

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Section: Discussionmentioning

confidence: 99%

Efficacy of Whole-Body Vibration Training on Brain-Derived Neurotrophic Factor, Clinical and Functional Outcomes, and Quality of Life in Women with Fibromyalgia Syndrome: A Randomized Controlled Trial

Ribeiro

Lacerda

Santos

et al. 2021

Journal of Healthcare Engineering

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“…Others studies attempted to associate poor sleep in FM with immune system changes (percentage of T lymphocytes and natural killer [NK] cells) or inflammatory markers (interleukin [IL]‐6, IL‐1, and tumor necrosis factor‐alpha) . Landis found minimal alterations of the immune system and absence of alterations of NK lymphocytes function and FM symptoms.…”

Section: Resultsmentioning

confidence: 99%

“…Poor quality of sleep in patients with FM was found to be associated with high rates of depression, anxiety and poor quality of life …”

Section: Resultsmentioning

confidence: 99%

Fibromyalgia, sleep disturbance and menopause: Is there a relationship? A literature review

et al. 2019

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Introduction Fibromyalgia (FM) symptoms worsen in a significant portion of patients with the onset of menopause. Some patients report that their symptoms begin after menopause, suggesting a relationship between these entities. Sleep disturbance is a common condition in FM and menopause, and it is associated with chronic pain. Methods/Objectives Several electronic databases were searched, from the first available year to April 2018 to evaluate the publications that assessed the effects of menopause and sleep disturbance on the appearance or worsening of FM and the role of hormone therapy for these patients. Results The results are summarized in three tables. The objective sleep patterns of FM patients included high sleep latency, frequent arousals and intrusion of alpha wave sleep and NREM (non‐rapid eye movement) sleep in delta sleep. Poor sleep during menopause is more frequent in late perimenopause and surgical menopause, and may be related to vasomotor symptoms or not. Hormone therapy exerted a positive effect on subjective sleep quality of symptomatic menopausal women. Studies have shown a high association between FM and early and surgical menopause. Raloxifene exerted a positive effect on pain and sleep in FM patients; however one study that analyzed the effects of transdermal estrogen therapy found no improvement in subjective and objective parameters of pain. Conclusion Further studies are needed to elucidate the nature of the association between menopause, sleep and persistent pain syndromes, such as FM, showing the role of hormone therapy in prospective placebo‐controlled trials.

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“…Among the different ways of assessing these sleep problems, subjective measures through questionnaires have great clinical utility due to their simplicity and low cost, but may provide results that do not exactly match those obtained through objective measurements [39]. Very few studies exist in the literature on the objective assessment of sleep in FM patients, particularly through accelerometry.…”

Section: Discussionmentioning

confidence: 99%

Subjective Sleep Quality Versus Objective Accelerometric Measures of Sleep and Systemic Concentrations of Sleep-Related Hormones as Objective Biomarkers in Fibromyalgia Patients

et al. 2023

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Poor quality of sleep leads to an increase in severity of the symptoms associated with fibromyalgia (FM) syndrome and vice versa. The aim of this study was to determine if the poor perceived sleep quality in FM patients could be corroborated by objective physiological determinations. Perceived sleep quality was evaluated (through the Pittsburgh Sleep Quality Index) in 68 FM patients compared to an age-matched reference group of 68 women without FM. Objective sleep quality (measured using accelerometry), and systemic concentrations of sleep-related hormones (catecholamines, oxytocin, serotonin, and melatonin) were evaluated in two representative groups from the reference control group (n = 11) and FM patients (n = 11). FM patients reported poorer subjective sleep quality compared to the reference group. However, no significant differences were found in accelerometry parameters, except for a delay in getting in and out of bed. In addition, FM patients showed no significant differences in oxytocin concentration and adrenaline/noradrenaline ratio, as well as a lower serotonin/melatonin ratio. Poor perception of sleep quality in FM patients does not correspond to objective determinations. A dysregulation of the stress response could be associated with the delay in their resting circadian rhythm and difficulty falling asleep. This would be the cause that justifies the perceived lack of rest and the fatigue they feel when waking up.

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Objective measures of sleep in fibromyalgia syndrome: Relationship to clinical, psychiatric, and immunological variables

Cited by 6 publications

References 36 publications

Efficacy of Whole-Body Vibration Training on Brain-Derived Neurotrophic Factor, Clinical and Functional Outcomes, and Quality of Life in Women with Fibromyalgia Syndrome: A Randomized Controlled Trial

Efficacy of Whole-Body Vibration Training on Brain-Derived Neurotrophic Factor, Clinical and Functional Outcomes, and Quality of Life in Women with Fibromyalgia Syndrome: A Randomized Controlled Trial

Fibromyalgia, sleep disturbance and menopause: Is there a relationship? A literature review

Subjective Sleep Quality Versus Objective Accelerometric Measures of Sleep and Systemic Concentrations of Sleep-Related Hormones as Objective Biomarkers in Fibromyalgia Patients

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