Objective Measures of Neural Processing of Interaural Time Differences

McAlpine, David; Haywood, Nicholas R.; Undurraga, Jaime A.; Marquardt, Torsten

doi:10.1007/978-3-319-25474-6_21

Cited by 11 publications

(11 citation statements)

References 22 publications

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“…Also the maximum carrier frequency for which IPDs evoke cortical auditory evoked potentials decreases by middle-age ( Papesh et al., 2017 ; Ross et al., 2007 ). Do note that cortical auditory evoked potentials merely indicate a detection of change ( Clinard, Tremblay, & Krishnan, 2010 ), whereas the IPM-FRs extend our knowledge of the auditory system by quantifying the relative processing of different IPM depths ( Haywood et al., 2015 ; McAlpine et al., 2016 ; Undurraga et al., 2016 ).…”

Section: Discussionmentioning

confidence: 99%

“…IPM-FRs presumably originate from neurons in cortical areas ( Haywood et al., 2015 ; McAlpine et al., 2016 ; Undurraga et al., 2016 ). However, changes in IPM-FRs could also reflect reduced low-level temporal resolution.…”

Section: Discussionmentioning

confidence: 99%

“…Neural IPD processing was investigated electrophysiologically by means of interaural phase modulation—following responses (IPM-FRs; Haywood et al., 2015 ; McAlpine et al., 2016 ; Undurraga et al., 2016 ). The IPM-FRs were evoked by IPMs, that is, periodic changes in IPDs over time that were embedded in the TFS of acoustic stimulation.…”

Section: Methodsmentioning

confidence: 99%

“…To this end, this study examined neural and behavioral IPD processing in six participant groups: young, middle-aged, and older participants, with either normal hearing (NH) thresholds or sensorineural HI (i.e., originating at cochlear or neural level). Neural IPD processing was studied electrophysiologically using a recently developed measure that records neural responses to periodic changes in IPDs over time, embedded in the TFS of acoustic stimuli ( Haywood, Undurraga, Marquardt, & McAlpine, 2015 ; McAlpine, Haywood, Undurraga, & Marquardt, 2016 ; Undurraga, Haywood, Marquardt, & McAlpine, 2016 ). In addition, behavioral IPD processing was examined through IPD discrimination thresholds, obtained for similar stimuli as those applied during the electrophysiological measurements.…”

Section: Introductionmentioning

confidence: 99%

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Electrophysiological and Behavioral Evidence of Reduced Binaural Temporal Processing in the Aging and Hearing Impaired Human Auditory System

et al. 2018

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A person’s ability to process temporal fine structure information is indispensable for speech understanding. As speech understanding typically deteriorates throughout adult life, this study aimed to disentangle age and hearing impairment (HI)-related changes in binaural temporal processing. This was achieved by examining neural and behavioral processing of interaural phase differences (IPDs). Neural IPD processing was studied electrophysiologically through steady-state activity in the electroencephalogram evoked by periodic changes in IPDs over time, embedded in the temporal fine structure of acoustic stimulation. In addition, behavioral IPD discrimination thresholds were determined for the same stimuli. To disentangle potential effects of age from those of HI, both measures were applied to six participant groups: young, middle-aged, and older persons, with either normal hearing or sensorineural HI. All participants passed a cognitive screening, and stimulus audibility was controlled for in participants with HI. The results demonstrated that HI changes neural processing of binaural temporal information for all age-groups included in this study. These outcomes were revealed, superimposed on age-related changes that emerge between young adulthood and middle age. Poorer neural outcomes were also associated with poorer behavioral performance, even though the behavioral IPD discrimination thresholds were affected by age rather than by HI. The neural outcomes of this study are the first to evidence and disentangle the dual load of age and HI on binaural temporal processing. These results could be a valuable first step toward future research on rehabilitation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Electrophysiological and Behavioral Evidence of Reduced Binaural Temporal Processing in the Aging and Hearing Impaired Human Auditory System

et al. 2018

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“…Recently, there has been growing interest in the use of a new electrophysiological measure called the interaural phase modulation-following response (IPM-FR), which has been developed as a more efficient method to assess the neural encoding of IPDs (Haywood et al, 2015;McAlpine et al, 2016;Undurraga et al, 2016). Similar to neural responses measured by Ross et al (2007a;2007b) and Papesh et al (2017), this response is elicited by a shift in the phase of an AM carrier tone at the two ears.…”

Section: Introductionmentioning

confidence: 99%

Age-Related Deficits in Electrophysiological and Behavioral Measures of Binaural Temporal Processing

et al. 2020

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Binaural processing, particularly the processing of interaural phase differences, is important for sound localization and speech understanding in background noise. Age has been shown to impact the neural encoding and perception of these binaural temporal cues even in individuals with clinically normal hearing sensitivity. This work used a new electrophysiological response, called the interaural phase modulation-following response (IPM-FR), to examine the effects of age on the neural encoding of interaural phase difference cues. Relationships between neural recordings and performance on several behavioral measures of binaural processing were used to determine whether the IPM-FR is predictive of interaural phase difference sensitivity and functional speech understanding deficits. Behavioral binaural frequency modulation detection thresholds were measured to assess sensitivity to interaural phase differences while spatial release-from-masking thresholds were used to assess speech understanding abilities in spatialized noise. Thirty adults between the ages of 35 to 74 years with normal low-frequency hearing thresholds were used in this study. Data showed that older participants had weaker neural responses to the interaural phase difference cue and were less able to take advantage of binaural cues for speech understanding compared to younger participants. Results also showed that the IPM-FR was predictive of performance on the binaural frequency modulation detection task, but not on the spatial release-from-masking task after accounting the effects of age. These results confirm previous work that showed that the IPM-FR reflects age-related declines in binaural temporal processing and provide further evidence that this response may represent a useful objective tool for assessing binaural function. However, further research is needed to understand how the IPM-FR is related to speech understanding abilities.

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Neural Representation of Interaural Time Differences in Humans—an Objective Measure that Matches Behavioural Performance

Undurraga

Haywood

Marquardt

et al. 2016

JARO

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Humans, and many other species, exploit small differences in the timing of sounds at the two ears (interaural time difference, ITD) to locate their source and to enhance their detection in background noise. Despite their importance in everyday listening tasks, however, the neural representation of ITDs in human listeners remains poorly understood, and few studies have assessed ITD sensitivity to a similar resolution to that reported perceptually. Here, we report an objective measure of ITD sensitivity in electroencephalography (EEG) signals to abrupt modulations in the interaural phase of amplitude-modulated low-frequency tones. Specifically, we measured following responses to amplitude-modulated sinusoidal signals (520-Hz carrier) in which the stimulus phase at each ear was manipulated to produce discrete interaural phase modulations at minima in the modulation cycle—interaural phase modulation following responses (IPM-FRs). The depth of the interaural phase modulation (IPM) was defined by the sign and the magnitude of the interaural phase difference (IPD) transition which was symmetric around zero. Seven IPM depths were assessed over the range of ±22 ° to ±157 °, corresponding to ITDs largely within the range experienced by human listeners under natural listening conditions (120 to 841 μs). The magnitude of the IPM-FR was maximal for IPM depths in the range of ±67.6 ° to ±112.6 ° and correlated well with performance in a behavioural experiment in which listeners were required to discriminate sounds containing IPMs from those with only static IPDs. The IPM-FR provides a sensitive measure of binaural processing in the human brain and has a potential to assess temporal binaural processing.

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Objective Measures of Neural Processing of Interaural Time Differences

Cited by 11 publications

References 22 publications

Electrophysiological and Behavioral Evidence of Reduced Binaural Temporal Processing in the Aging and Hearing Impaired Human Auditory System

Electrophysiological and Behavioral Evidence of Reduced Binaural Temporal Processing in the Aging and Hearing Impaired Human Auditory System

Age-Related Deficits in Electrophysiological and Behavioral Measures of Binaural Temporal Processing

Neural Representation of Interaural Time Differences in Humans—an Objective Measure that Matches Behavioural Performance

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