Objective evaluation of visibility in virtual chromoendoscopy for esophageal squamous carcinoma using a color difference formula

Inoue, Masahito; Miyake, Yoichi; Odaka, Takeo; Satô, Tôru; Watanabe, Yoshiyuki; Sakama, Atsunori; Zenbutsu, Satoki; Yokosuka, Osamu

doi:10.1117/1.3502666

Cited by 7 publications

(4 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4). The color difference between cancer and the background mucosa is higher with FICE than with WLI, 34 suggesting that FICE is useful for detection of this cancer. However, any intraepithelial papillary capillary loops (IPCL) are not clearly visualized compared to what is seen with NBI.…”

Section: Esophageal Diseases Using Ficementioning

confidence: 95%

Present and future status of flexible spectral imaging color enhancement and blue laser imaging technology

Osawa

Yamamoto

2013

Digestive Endoscopy

143

119

View full text Add to dashboard Cite

The usefulness of flexible spectral imaging color enhancement (FICE) has been reported for evaluating the esophagus, stomach, and small and large intestine. Higher contrast is shown between cancer and the surrounding mucosa in the esophagus and stomach and may facilitate the detection of gastric cancers missed by white light imaging alone. The surface patterns of gastric mucosa are clearly visualized in non-malignant areas but are irregular and blurred in malignant areas, leading to clear demarcation. Capsule endoscopy with FICE detects angiodysplasia and erosions of the small intestine. The surface and vascular pattern with FICE is useful for the differential diagnosis of colorectal polyps. However, FICE remains somewhat poor at visualizing mucosal microvasculature on a tumor surface. Narrow-band imaging (NBI) is dark in observing whole gastric mucosa and poor at visualizing mucosal microstructure. Blue laser imaging (BLI) has the potential to resolve these limitations. Narrow-band laser light combined with white light shows irregular microvessels on both differentiated and undifferentiated gastric cancer similar to those using NBI. In addition, irregular surface patterns including minute white zones are clearly seen on the uneven surface of differentiated lesions, resulting in exclusion of undifferentiated lesions. Using both distant and close-up views, a high contrast between green intestinal metaplasia and brown gastric cancer may lead to early detection of gastric cancers and determination of a demarcation line. BLI produces high-contrast images in esophageal cancer with clear vision of intrapapillary capillary loops and also predicts the histopathological diagnosis and depth of invasion in colorectal neoplasms.

show abstract

Section: Esophageal Diseases Using Ficementioning

confidence: 95%

Present and future status of flexible spectral imaging color enhancement and blue laser imaging technology

Osawa

Yamamoto

2013

Digestive Endoscopy

143

119

View full text Add to dashboard Cite

show abstract

“…Recently, several superficial esophageal cancers have been detected owing to improvements in digestive endoscopy. Specifically, image-enhanced endoscopy with magnification including narrow-band imaging, BLI, and flexible spectral imaging color enhancement has enabled clear visualization of the microsvasculature of the tumor surface 5 10 11 12 , which led to the discovery that changes in microvasculature reflect the depth of superficial esophageal cancer 2 3 4 .…”

Section: Discussionmentioning

confidence: 99%

Comparative analysis of avascular areas in superficial esophageal squamous cell carcinomas using in vivo and ex vivo magnifying endoscopy

et al. 2017

View full text Add to dashboard Cite

Background and study aims An avascular area (AVA), one of the microvasculature changes in superficial esophageal cancers, appears when a tumor demonstrates a bulky growth pattern. We aimed to compare endoscopic and histopathological findings by observing formalin-fixed AVA specimens using magnifying endoscopy. Patients and methods A prospective analysis was conducted on 16 patients with superficial esophageal cancer, including AVA, who underwent endoscopic submucosal dissection (ESD). Magnifying endoscopy and blue laser imaging were used to identify AVAs. After the ESD, the AVA width was measured on formalin-fixed specimens using magnifying endoscopy, and AVA thickness and depth were determined after hematoxylin and eosin staining using microscopy. Results Mean AVA widths of M1, M2, and M3/SM-lesions were 0.434, 0.578, and 0.835 mm, respectively (M1 vs. M2, P = 0.16; M2 vs. M3/SM-, P = 0.07). Mean AVA thicknesses of M1, M2, and M3/SM-lesions were significantly different (0.176, 0.518, and 0.800 mm; M1 vs. M2, P < 0.01; M2 vs. M3/SM-, P < 0.05). There was a significant correlation between AVA width and thickness. Conclusions AVA size can be measured accurately on formalin-fixed specimens with magnifying endoscopy. AVA thickness can be useful for determining tumor depth.

show abstract

“…Ordinary endoscopic pictures are taken by charge-coupled device camera in a regular endoscopy and arithematically processed. Different from NBI system with fixed wavelengths, composite FICE images are generated on a computer which allows viewing of an image taken under light at any suitable wavelength setting for specific condition [26, 27]. Between wavelength 400 nm and 695 nm of visible light, 60 spectral images at 5 nm interval can be selected.…”

Section: Image-enhanced Endoscopy Screening Of Upper Gastrointestimentioning

confidence: 99%

“…The method of selecting a suitable combination of wavelengths of RGB lights for esophageal squamous epithelium has not been well established. Inoue et al have shown that the specific FICE modes A (R 550 nm, gain 2; G 500 nm, gain 2; B 470 nm, gain 3) and C (R 540 nm, gain 2; G 415 nm, gain 2; B 415 nm, gain 3) significantly enhanced the visibility of IPCLs of ESCC mucosa [27]. Some investigators have demonstrated a superior outcome in the diagnostic yield of esophageal capsule endoscopy by combination of the FICE system mode A with the PillCam ESO2 (Given Imaging, Yoqneam, Israel) [59].…”

Section: The Application Of Iee In Esophagusmentioning

confidence: 99%

Screening for Precancerous Lesions of Upper Gastrointestinal Tract: From the Endoscopists' Viewpoint

Chung

Wang²

2013

Gastroenterology Research and Practice

View full text Add to dashboard Cite

Upper gastrointestinal tract cancers are one of the most important leading causes of cancer death worldwide. Diagnosis at late stages always brings about poor outcome of these malignancies. The early detection of precancerous or early cancerous lesions of gastrointestinal tract is therefore of utmost importance to improve the overall outcome and maintain a good quality of life of patients. The desire of endoscopists to visualize the invisibles under conventional white-light endoscopy has accelerated the advancements in endoscopy technologies. Nowadays, image-enhanced endoscopy which utilizes optical- or dye-based contrasting techniques has been widely applied in endoscopic screening program of gastrointestinal tract malignancies. These contrasting endoscopic technologies not only improve the visualization of early foci missed by conventional endoscopy, but also gain the insight of histopathology and tumor invasiveness, that is so-called optical biopsy. Here, we will review the application of advanced endoscopy technique in screening program of upper gastrointestinal tract cancers.

show abstract

Objective evaluation of visibility in virtual chromoendoscopy for esophageal squamous carcinoma using a color difference formula

Cited by 7 publications

References 22 publications

Present and future status of flexible spectral imaging color enhancement and blue laser imaging technology

Present and future status of flexible spectral imaging color enhancement and blue laser imaging technology

Comparative analysis of avascular areas in superficial esophageal squamous cell carcinomas using in vivo and ex vivo magnifying endoscopy

Screening for Precancerous Lesions of Upper Gastrointestinal Tract: From the Endoscopists' Viewpoint

Contact Info

Product

Resources

About