Objective Evaluation of Vagectomy-Antrectomy for Duodenal Ulcer

The "Combined" Operation for Peptic Ulcer

“…1,5,7,8,[12][13][14] The concepts upon which this operation is founded are of both experimental and clinical origin. The importance of the antral and the cephalic phases of gastric acid secretion has been shown experimentally by many investigators, and their laboratory findings have been corroborated by clinical experience.2,3·4·13'1''17·18'20 It has been increasingly evident that the combined effects of the antrum, through elaboration and release of the hormone gastrin, and of the parietal cellstimulatory activity of the vagus nerves, are principally responsible for the increased acid secretion which initiates and maintains peptic ulcération.…”