Objective evaluation of the efficacy of mometasone furoate (nozefrin) in the treatment of polypoid rhinosinusitis

Mashkova, T. A.; Mal’tsev, A. B.

doi:10.17116/rosrino20182604156

Cited by 2 publications

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References 9 publications

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“…По мнению многих исследователей, это связанно с отсутствием мукоцилиарного транспорта, усилением вредного воздействия продуктов распада бактерий и выделений в открытой и плохо дренируемой ране и вскрытых параназальных синусах, а также с гематогенным распространением токсинов и аллергенов. Лица, страдающие аллергией и бронхиальной астмой, нередко переводятся на системные кортикостероиды [7,8].…”

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The experience of using Frinosole in the early postoperative period in patients after endonasal endoscopic operations

Mashkova¹,

Mal’tsev²

2020

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The effectiveness of the drug Frinosole in the complex treatment of early postoperative changes in the nasal mucosa after endonasal endoscopic surgery was studied. It has been confirmed that during surgical trauma of the mucous membrane of the nasal cavity, inhibition of the main functions of the respiratory epithelium occurs with a sharp increase in the absorption capacity of the mucous membrane of the nasal cavity. These changes correlate with the clinical picture of the early postoperative period. The data presented indicate a high efficacy of the drug in complex postoperative treatment and make it possible to recommend it for wider use in order to minimize the duration of the postoperative healing stages and prevent possible complications associated with excessive granulation and scarring of the nasal mucosa in the surgical areas.

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Section: ;19;3(106)unclassified

The experience of using Frinosole in the early postoperative period in patients after endonasal endoscopic operations

Mashkova¹,

Mal’tsev²

2020

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The role of intranasal steroid therapy in the treatment of chronic sinusitis with nasal polyps

Sobolev

Биданова

2021

Medicinskij sovet

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Polypoid rhinosinusitis (PRS) is a form of chronic rhinosinusitis (CRS), which is a heterogeneous group of pathological conditions based on a chronic inflammatory process of the nasal cavity and paranasal sinuses (PNS), leading to polypoid tissue formation. In most cases, T2-inflammation underlies the pathogenetic mechanism of PRS. In the presence of T2-associated conditions, the course of PRS is usually severe. The main aim of PRS treatment is to control symptoms, prolong the recurrence-free period, and restore the aeration of the PNS. The basic therapy of PRS involves the use of intranasal glucocorticosteroids (InGCS), which have a nonspecific anti-inflammatory effect by acting on different points of the pathological inflammatory process. The level of evidence for the use of InGCS is Ia: the drugs are included in Russian and foreign clinical guidelines for the treatment of polypoid rhinosinusitis. InGCS have high topical activity at low steroid doses. Mometasone furoate has an important place among this group of drugs because of its high efficacy, long-lasting therapeutic effect and optimal safety profile. The drug is officially registered for the treatment of PRS. Long-term use of mometazone furoate has been clinically observed to cause almost no atrophic nasal mucosal changes. It can be administered as monotherapy and in combination therapy over long periods of time in all phases of the treatment of PRS.

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Objective evaluation of the efficacy of mometasone furoate (nozefrin) in the treatment of polypoid rhinosinusitis

Cited by 2 publications

References 9 publications

The experience of using Frinosole in the early postoperative period in patients after endonasal endoscopic operations

The experience of using Frinosole in the early postoperative period in patients after endonasal endoscopic operations

The role of intranasal steroid therapy in the treatment of chronic sinusitis with nasal polyps

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