Objective evaluation of choroidal melanin loss in patients with Vogt–Koyanagi–Harada disease using polarization-sensitive optical coherence tomography

Miura, Masahiro; Makita, Shuichi; Yasuno, Yoshiaki; Azuma, Shinnosuke; Mino, Toshihiro; Yamaguchi, Tatsuo; Iwasaki, Takuya; Nemoto, Rei; Shimizu, Hiroyuki; Gotô, Hiroshi

doi:10.1038/s41598-022-07591-9

Cited by 5 publications

(2 citation statements)

References 35 publications

(61 reference statements)

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“…However, previous studies reported that the color balance of fundus photographs is affected by choroid thickness, media opacity, and imaging artifacts, and limitations exist in determining whether SGF develops in patients with VKH disease. 24 , 31 , 32 Consistent with previous studies, 24 , 31 , 32 in the present study, the degree of fundus pigmentation did not differ between VKH disease–affected eyes with and without SGF, nor between the eyes of normal controls and VKH disease–affected eyes without SGF. Using en face OCT images, the number and total area of HCF in VKH disease–affected eyes with SGF were significantly lower than those in VKH disease–affected eyes without SGF and normal controls.…”

Section: Discussionsupporting

confidence: 92%

Correlation Between Hyperreflective Foci in the Choroid and Choroidal Discoloration in Vogt-Koyanagi-Harada Disease

Kim

Togloom

2022

Invest. Ophthalmol. Vis. Sci.

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Purpose To investigate the distribution of hyperreflective choroidal foci (HCF) in eyes with Vogt-Koyanagi-Harada (VKH) disease. Methods We included 22 eyes of 11 patients with VKH disease in the convalescent stages and 22 eyes of age- and sex-matched normal controls. HCF were quantified using en face optical coherence tomography (OCT) images of the choroid, and the degree of fundus pigmentation was determined by the color balance of the fundus photographs. The results were then analyzed between the eyes with and without sunset glow fundus (SGF). Results The median age of patients with VKH disease was 58.0 (range 54.0–65.0) years, and median disease duration was 66.4 (range 8.5–147.7) months. In 22 eyes with VKH, the number and total area of HCF were correlated with the degree of fundus pigmentation ( ρ = −0.671, P < 0.001; ρ = −0.612, P = 0.002, respectively). The number of HCF was significantly smaller in VKH disease–affected eyes with SGF (median, interquartile range; 134.6, 110.0–159.2) than in those without SGF (229.0, 197.0–261.0) and the eyes of normal controls (211.8, 190.3–233.4). Conclusions HCF distributions correlated with the degree of fundus pigmentation in eyes with VKH disease. Quantitative measurements of HCF on en face OCT images can be a novel tool in evaluating choroidal pigmentation in patients with VKH disease.

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Section: Discussionsupporting

confidence: 92%

Correlation Between Hyperreflective Foci in the Choroid and Choroidal Discoloration in Vogt-Koyanagi-Harada Disease

Kim

Togloom

2022

Invest. Ophthalmol. Vis. Sci.

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“…After PS-OCT studies showed that retinal pigments exhibit low DOPU [44], JM-OCT was also adopted to investigate the retinal pigment epithelium (RPE) [58]- [60], [77], [95] and choroidal melanin [95]- [98] through DOPU imaging. The former application was found to be useful in the investigation of exudative retinal diseases, such as age-related macular degeneration [46], [60], [99], whereas the latter was found to be useful in the staging of Vogt-Koyanagi-Harada disease [96], [97].…”

Section: A Retinal Investigationmentioning

confidence: 99%

Multi-Contrast Jones-Matrix Optical Coherence Tomography—The Concept, Principle, Implementation, and Applications

Yasuno

2023

IEEE J. Select. Topics Quantum Electron.

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Jones-matrix optical coherence tomography (JM-OCT) is an extension of polarization-sensitive OCT, which provides multiple types of optical contrasts of biological and clinical samples. JM-OCT measures the spatial distribution of the Jones matrix of the sample and also its time sequence. All contrasts (i.e., multi-contrast OCT images) are then computed from the Jones matrix. The contrasts obtained from the Jones matrix include not only the conventional and polarization-insensitive OCT intensity, cumulative and local phase retardation (birefringence), degreeof-polarization uniformity quantifying the polarization randomness of the sample, diattenuation, but also signal attenuation coefficient, sample scatterer density, Doppler OCT, OCT angiography, and dynamic OCT that contrasts intracellular motility or metabolism by analyzing the temporal fluctuation of the OCT signal. JM-OCT is a generalized version of OCT because it measures the generalized form of the sample information; i.e., the Jones matrix sequence. This review summarizes the basic conception, mathematical principle, hardware implementation, signal and image processing, and biological and clinical applications of JM-OCT. Advanced technical topics, including JM-OCTspecific noise correction and quantity estimation and JM-OCT's self-calibration nature, are also described.

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Synthesizing the degree of polarization uniformity from non-polarization-sensitive optical coherence tomography signals using a neural network

Makita¹,

Miura

Azuma

et al. 2023

Biomed. Opt. Express

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Degree of polarization uniformity (DOPU) imaging obtained by polarization-sensitive optical coherence tomography (PS-OCT) has the potential to provide biomarkers for retinal diseases. It highlights abnormalities in the retinal pigment epithelium that are not always clear in the OCT intensity images. However, a PS-OCT system is more complicated than conventional OCT. We present a neural-network-based approach to estimate the DOPU from standard OCT images. DOPU images were used to train a neural network to synthesize the DOPU from single-polarization-component OCT intensity images. DOPU images were then synthesized by the neural network, and the clinical findings from ground truth DOPU and synthesized DOPU were compared. There is a good agreement in the findings for RPE abnormalities: recall was 0.869 and precision was 0.920 for 20 cases with retinal diseases. In five cases of healthy volunteers, no abnormalities were found in either the synthesized or ground truth DOPU images. The proposed neural-network-based DOPU synthesis method demonstrates the potential of extending the features of retinal non-PS OCT.

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Objective evaluation of choroidal melanin loss in patients with Vogt–Koyanagi–Harada disease using polarization-sensitive optical coherence tomography

Cited by 5 publications

References 35 publications

Correlation Between Hyperreflective Foci in the Choroid and Choroidal Discoloration in Vogt-Koyanagi-Harada Disease

Correlation Between Hyperreflective Foci in the Choroid and Choroidal Discoloration in Vogt-Koyanagi-Harada Disease

Multi-Contrast Jones-Matrix Optical Coherence Tomography—The Concept, Principle, Implementation, and Applications

Synthesizing the degree of polarization uniformity from non-polarization-sensitive optical coherence tomography signals using a neural network

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